全文获取类型
收费全文 | 1532篇 |
免费 | 65篇 |
国内免费 | 66篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 70篇 |
妇产科学 | 88篇 |
基础医学 | 168篇 |
口腔科学 | 45篇 |
临床医学 | 184篇 |
内科学 | 322篇 |
皮肤病学 | 32篇 |
神经病学 | 26篇 |
特种医学 | 268篇 |
外科学 | 186篇 |
综合类 | 38篇 |
预防医学 | 58篇 |
眼科学 | 60篇 |
药学 | 64篇 |
肿瘤学 | 52篇 |
出版年
2021年 | 13篇 |
2020年 | 9篇 |
2019年 | 13篇 |
2018年 | 13篇 |
2017年 | 14篇 |
2016年 | 12篇 |
2015年 | 25篇 |
2014年 | 25篇 |
2013年 | 33篇 |
2012年 | 46篇 |
2011年 | 51篇 |
2010年 | 54篇 |
2009年 | 57篇 |
2008年 | 38篇 |
2007年 | 85篇 |
2006年 | 41篇 |
2005年 | 44篇 |
2004年 | 32篇 |
2003年 | 24篇 |
2002年 | 36篇 |
2001年 | 36篇 |
2000年 | 32篇 |
1999年 | 19篇 |
1998年 | 64篇 |
1997年 | 77篇 |
1996年 | 72篇 |
1995年 | 66篇 |
1994年 | 47篇 |
1993年 | 54篇 |
1992年 | 24篇 |
1991年 | 32篇 |
1990年 | 21篇 |
1989年 | 51篇 |
1988年 | 33篇 |
1987年 | 46篇 |
1986年 | 17篇 |
1985年 | 37篇 |
1984年 | 21篇 |
1983年 | 27篇 |
1982年 | 21篇 |
1981年 | 20篇 |
1980年 | 29篇 |
1979年 | 13篇 |
1978年 | 12篇 |
1977年 | 9篇 |
1975年 | 17篇 |
1974年 | 17篇 |
1971年 | 9篇 |
1970年 | 9篇 |
1966年 | 9篇 |
排序方式: 共有1663条查询结果,搜索用时 15 毫秒
1.
Widely Metastatic Squamous Cell Carcinoma Originating from Malignant Transformation of Hypertrophic Lichen Planus in a 24‐Year‐Old Woman: Case Report and Review of the Literature
下载免费PDF全文
![点击此处可从《Pediatric dermatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Lana X. Tong B.A. Matthew J. Weinstock M.D. Reed Drews M.D. Caroline C. Kim M.D. 《Pediatric dermatology》2015,32(3):e98-e101
Hypertrophic lichen planus (HLP) is a T‐cell‐mediated process typically presenting with hypertrophic or verrucous plaques on the lower limbs. We report the case of a 24‐year‐old woman with a history of HLP since age 3 years presenting with rapid malignant transformation of one lesion into a large squamous cell carcinoma (SCC). Subsequent examination revealed progressive, widespread metastatic involvement, and the patient ultimately died from her disease. SCC associated with HLP is rare, with a review of the literature revealing fewer than 50 cases. This case highlights the need to be aware of suspicious changes in HLP and to educate patients as to when to be reevaluated. 相似文献
2.
3.
Leonidas JC; Berdon WE; Valderrama E; Neveling U; Schuval S; Weiss SJ; Hilfer C; Godine L 《Radiology》1996,198(2):377
4.
5.
6.
7.
8.
Association of human polyomavirus JC with peripheral blood of immunoimpaired and healthy individuals
Drries Kristina Sbiera Silviu Drews Klaus Arendt Gabriele Eggers Christian Drries Rdiger 《Journal of neurovirology》2003,9(1):81-87
JC virus (JCV) infection is regularly asymptomatic in healthy individuals. In contrast, in immunocompromised individuals, highly activated virus replication may lead to PML. Peripheral blood cells (PBCs) are found to habor JCV DNA in healthy and diseased individuals and it is discussed that they might be responsible for dissemination of the virus to the central nervous system (CNS) during persistence. To better understand the role of JCV DNA in PBCs for persistent infection and pathogenesis, the authors characterized the extent of JCV infection in Ficoll-gradient purified blood cells (peripheral blood mononuclear cells [PBMCs]) of healthy and human immunodeficiency virus type 1 (HIV-1)-infected individuals. Virus activation in PBMCs from healthy JCV-infected individuals was found at a rate of 0% to 38% at low polymerase chain reaction (PCR) sensitivity. In progressive multifocal leukoencephalopathy (PML) patients, a stronger signal was found, indicating increased virus activation. JCV DNA was regularly detected in T and B lymphocytes and in monocytes at low levels. However, granulocytes were shown to be the predominant reservoir of JCV DNA harboring high copy numbers. Although the overall distribution of viral genomes holds true for the population studied, in the individual, a markedly changed pattern of distribution can be found. 相似文献
9.
T. A. Drews K. G. Lamping D. E. Laughlin W. P. Dole 《Medical & biological engineering & computing》1987,25(4):420-427
Although present sonomicrometer techniques for measuring continuous changes in vascular diameter are very useful, two problems
with available methods are difficulty in maintaining crystal alignment throughout an acute experiment and inability to measure
absolute dimensions less than 1 mm. We have designed and ultrasonic dimension gauge system to over come these problems. The
design uses a gate to pass a 20 MHz signal to a counter during the sonic travel time between crystals, and then converts the
digital count to an analogue voltage. Interference from the transmitting impulse in the received signal was minimised using
MOSFET transistors allowing measurements of absolute dimensions from 0.00 mm to 99.9 mm. An averaging effect which depends
upon the asynchrony between the basic timer and the counter clock results in a resolution of at least 10 μm. Repeated calibration
curves showed an accuracy of 2.5 μm without significant bias. Piezoelectric crystals were mounted to a lighweight stainless-steel
clip to facilitate attachment to the vessel and to maintain the crystals in focus during changes in diameter. Mean and phasic
diameters measured in the femoral artery with the clip device correlated well with measurements obtained with crystals sewn
to the adventitia of the femoral artery of the dog (slope =0.97, r=0.99). 相似文献
10.
Kaufmann SJ; Sharif K; Sharma V; McVerry BA 《Human reproduction (Oxford, England)》1998,13(2):498-499
The patient was diagnosed in childhood as having severe congenital
neutropenia and had recurrent admissions with severe infections. In 1987,
prior to getting married, she was sterilized. She continued to require i.v.
antibiotics when she contracted a severe infection. On one occasion, she
was treated with growth colony stimulating factor (G- CSF). Her increased
neutrophil count was sustained following this treatment. In June 1993, she
wished to start a family and underwent in- vitro fertilization (IVF)
treatment. G-CSF was given prior to oocyte retrieval. She conceived on her
first cycle and an ultrasound scan revealed a singleton pregnancy.
Throughout the course of the pregnancy, her white cell count was monitored
closely and remained at <1.0x10(9)/l. The pregnancy progressed
uneventfully and at 37 weeks gestation she was admitted for G-CSF
injections. At 38 weeks she was delivered of a boy weighing 3350 g, by
elective Caesarean section. His white cell count was normal. This is the
first case of G-CSF being used before conception and during pregnancy in a
patient with congenital neutropenia. It shows that advances in cytokine
therapy and close interdisciplinary liaison can lead to a successful
outcome and help patients, who would otherwise remain childless, to achieve
a family.
相似文献