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1.
Herein we developed a rapid, cheap, and water-soluble ultra-sensitive ZnO quantum dot (QD) based metal sensor for detecting different hazardous metal ions up to the picomolar range in water. Various spectroscopic and microscopic techniques confirmed the formation of 2.15 ± 0.46 μm of ZnO QD conjugated CMC microspheres (ZCM microspheres) which contain 5.5 ± 0.5 nm fluorescent zinc oxide (ZnO) QDs. Our system, as a promising sensor, exhibited excellent photostability and affinity towards various heavy metal ions. The detection limits were calculated to be 16 pM for Cu2+ and 0.18 nM for Cr6+ ions which are better than previously reported values. The simple fluorescence ‘turn off’ property of our ZCM microsphere sensor system can serve a two-in-one purpose by not only detecting the heavy metals but also quantifying them. Nonetheless, pattern recognition for different heavy metals helped us to detect and identify multiple heavy metal ions. Finally, their practical applications on real samples also demonstrated that the ZCM sensor can be effectively utilized for detection of Cr6+, Fe3+, Cu2+ present in the real water samples. This study may inspire future research and design of target fluorescent metal oxide QDs with specific functions.Herein we developed a rapid, cheap, and water-soluble ultra-sensitive ZnO quantum dot (QD) based metal sensor for detecting different hazardous metal ions up to the picomolar range in water. 相似文献
2.
Deep Dutta Manoj Kumar Ram Narayan Das Saumik Datta Dibakar Biswas Sujoy Ghosh Satinath Mukhopadhyay Subhankar Chowdhury 《Journal of clinical research in pediatric endocrinology》2013,5(4):266-269
Primary hyperparathyroidism (PHPT) is extremely uncommon among children and is more likely to be associated with genetic syndromes, multiglandular involvement, and more severe symptoms. Rickets can very rarely be the presenting feature of PHPT in children. Rickets was diagnosed in a 12-year-old girl presenting with short stature, genu valgum, eversion deformity at the ankle joints, and flat feet. Radiograms showed generalized osteopenia, widening of the distal ends of the long bones along with splaying, cupping and fraying. Biochemical evaluation revealed low serum calcium (7.8 mg/dL), low phosphorus (1.4 mg/dL), vitamin-D deficiency [25-hydroxy-vitamin-D (25(OH)D): 8.7 ng/mL], and elevated intact parathyroid hormone (PTH, 811 pg/mL). Re-evaluation due to lack of clinical improvement following vitamin-D and calcium supplementation revealed hypercalcemia 11.9 mg/dL, normal 25(OH)D 41 ng/mL, persistence of elevated PTH 632 pg/mL. A 99mTc-sestamibi scan showed increased uptake at the lower pole of the right lobe of the thyroid. A right inferior parathyroidectomy was performed. Histopathology revealed chief cell type parathyroid adenoma. Last evaluated 4 months after surgery, the bone pains and proximal weakness had resolved, with significant improvement in the patient’s quality of life. Rickets in the setting of PHPT often masks the classical phenotype of PHPT. In a child with rickets, lack of improvement following vitamin-D supplementation, hypercalcemia at presentation or following vitamin-D supplementation are warning signs which necessitate further evaluation to rule out PHPT.Conflict of interest:None declared. 相似文献
3.
Dibakar Chakrabarty Debasish Bhattacharyya Himadri S. Sarkar Sites C. Lahiri 《Toxicon》1993,31(12):1601-1614
A haemorrhagic toxin (VRH-1) has been purified to homogeneity from Vipera russelli russelli venom by subjecting it to chromatography twice successively on CM-Sephadex C-50. It is a protein of mol. wt 22,000 and contains one mole of Mg2+. Intradermal administration of this haemorrhagin in mice resulted in severe lung haemorrhage but produced little haemorrhage in skin. This apparent organ preference led us to develop a new haemorrhage assay method utilizing dye diffusion from lung in vitro. Proteolytic activity of VRH-1 was demonstrated using dimethylcasein as substrate following quantitation by reaction with trinitrobenzoyl sulfonic acid. Both haemorrhagic and proteolytic activities of VRH-1 were inhibited by serine protease inhibitors like phenylmethyl sulfonyl fluoride and chymostatin, but metal chelators had no effect. Lung haemorrhage is unlikely to be a direct reflection of a high local concentration of VRH-1. The administration of supernatant generated by incubation of chopped liver from untreated mouse and VRH-1 (in subhaemorrhagic dose) results in severe lung haemorrhage. This raises the possibility that VRH-1 leads to the formation of intermediate(s) which causes the haemorrhage. 相似文献
4.
Deep Dutta Manoj Kumar Anubhav Thukral Dibakar Biswas Rajesh Jain Sujoy Ghosh Satinath Mukhopadhyay Subhankar Chowdhury 《Journal of clinical research in pediatric endocrinology》2013,5(3):212-215
Thyroid ectopia (TE) is an embryological aberration of the thyroid gland migration most commonly observed in the lingual region followed by the sublingual, hyoid, and mediastinal regions. TE is often complicated by local compressive symptoms resulting in dysphagia, dysphonia, and dyspnea. Surgical removal of TE is frequently complicated by difficulties in intubation, increased perioperative bleeding, and severe primary hypothyroidism; on the other hand, I131 ablation is limited by high doses needed and the concern for long-term effects especially in children. We report three children with TE who all presented with compressive symptoms and were managed conservatively with levothyroxine resulting in resolution of compressive symptoms and favorable outcomes. Levothyroxine supplementation is effective and has an important role in managing TE, not only in correcting the associated hypothyroidism but also in resolving the associated compressive symptoms by reducing the size of the ectopic thyroid tissue.Conflict of interest:None declared. 相似文献
5.
Gautam Sengupta Mukherjee Dipankar Dibakar Das Jesuraj Lowrence Nimish Rai Srivastava Dharmendra Kumar 《Indian Journal of Thoracic and Cardiovascular Surgery》2008,24(2):134-137
Coronary artery aneurysms are uncommon and may be complicated by rupture, thromboembolic phenomenon, and more rarely fistulation
into one of the cardiac chambers. We report this rare case of right coronary artery aneurysm presented as acute inferior wall
myocardial infarction (MI). 相似文献
6.
Moumita Kundu Subhayan Das Dibakar Dhara Mahitosh Mandal 《Phytotherapy research : PTR》2019,33(10):2571-2584
Glioma is one of the most perplexing cancers because of its infiltrating nature, molecular signaling, and location in central nervous system. Blood–brain barrier acts as a natural barrier to the glioma making it difficult to access by conventional chemotherapy. Clinicians are using natural compounds or their derivatives for several diseases including different cancers. However, the feasibility of using natural compounds in glioma is not explored in details. Natural compounds can act over a wide variety of signaling pathways such as survival and metabolic pathways and induce cell death. Some of the natural agents have additional benefits of crossing biological barriers such as blood–brain barrier with ease having few or no impact on the surrounding healthy cells. All of these benefits make natural compounds a prospective candidate for the glioma management. This article evaluates the benefits of using natural compounds for glioma therapy and their possible mechanism of actions. We have discussed the natural compounds assessed currently for glioma therapy and proposed a few novel natural compounds with potential antiglioma effect based on their mechanism of action. 相似文献
7.
Nimish Rai Uday Narayan Sarkar Dibakar Das Shantanu Dutta Dharmendra Kumar Srivastava Shubhendu Sekhar Mahapatra 《Indian Journal of Thoracic and Cardiovascular Surgery》2010,26(3):222-224
Isolated iliac artery aneurysms without associated abdominal aortic aneurysms are rare. Incidence varies between 0.03% and 0.1%. Deep pelvic location of aneurysms, make their detection by physical examination very difficult. Usually they remain asymptomatic until ruptured. Other symptoms and signs are due to local compression of adjacent pelvic structure. Here we are presenting a case report of a patient with large unruptured isolated iliac artery aneurysm presented with abdominal lump and managed successfully. 相似文献
8.
Sushil Ranjan Ghosal Subhabrata Das Abhiram Maji Krishna Kamal Dey Dibakar Bagchi 《The Indian journal of surgery》2013,75(1):33-35
We report a rare case of adenocarcinoma in retroperitoneal teratoma in a 38 year old female patient who attended surgical OPD with complaints of dragging pain and heaviness in left lumbar region. Straight x-ray abdomen showed few irregular calcifications in left lumbar region. USG and CT showed it to be adrenal tumor and retroperitoneal teratoma respectively. Excised specimen confirmed it as mucin secreting adenocarcinoma in a case of retroperitoneal teratoma. 相似文献
9.
Sleep and Breathing - A close association of oxidative stress (OS) and ischemia-modified albumin (IMA) with obstructive sleep apnea (OSA) has been reported in the literature, but the results on IMA... 相似文献
10.
Rashna Dass Hazarika Nayan Mani Deka A. B. Khyriem W. V. Lyngdoh Himesh Barman Sourabh Gohain Duwarah Pankaj Jain Dibakar Borthakur 《Indian journal of pediatrics》2013,80(5):359-364