全文获取类型
收费全文 | 14061篇 |
免费 | 1030篇 |
国内免费 | 32篇 |
专业分类
耳鼻咽喉 | 118篇 |
儿科学 | 430篇 |
妇产科学 | 447篇 |
基础医学 | 2093篇 |
口腔科学 | 241篇 |
临床医学 | 1807篇 |
内科学 | 2477篇 |
皮肤病学 | 408篇 |
神经病学 | 1367篇 |
特种医学 | 272篇 |
外科学 | 1264篇 |
综合类 | 97篇 |
一般理论 | 38篇 |
预防医学 | 1579篇 |
眼科学 | 237篇 |
药学 | 1039篇 |
中国医学 | 24篇 |
肿瘤学 | 1185篇 |
出版年
2024年 | 14篇 |
2023年 | 140篇 |
2022年 | 328篇 |
2021年 | 551篇 |
2020年 | 278篇 |
2019年 | 492篇 |
2018年 | 516篇 |
2017年 | 352篇 |
2016年 | 457篇 |
2015年 | 437篇 |
2014年 | 614篇 |
2013年 | 771篇 |
2012年 | 1105篇 |
2011年 | 1166篇 |
2010年 | 641篇 |
2009年 | 524篇 |
2008年 | 877篇 |
2007年 | 913篇 |
2006年 | 891篇 |
2005年 | 826篇 |
2004年 | 713篇 |
2003年 | 633篇 |
2002年 | 601篇 |
2001年 | 85篇 |
2000年 | 78篇 |
1999年 | 81篇 |
1998年 | 109篇 |
1997年 | 78篇 |
1996年 | 71篇 |
1995年 | 60篇 |
1994年 | 73篇 |
1993年 | 51篇 |
1992年 | 48篇 |
1991年 | 50篇 |
1990年 | 34篇 |
1989年 | 40篇 |
1988年 | 37篇 |
1987年 | 20篇 |
1986年 | 25篇 |
1985年 | 34篇 |
1984年 | 31篇 |
1983年 | 29篇 |
1982年 | 30篇 |
1981年 | 36篇 |
1980年 | 31篇 |
1979年 | 17篇 |
1978年 | 19篇 |
1977年 | 23篇 |
1976年 | 17篇 |
1974年 | 16篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
Andres Eduardo Campuzano-García Bertha Torres-Alvarez Diana Hernández-Blanco 《Journal of cosmetic and laser therapy》2015,17(4):213-215
Hailey–Hailey disease (HHD), also known as benign familial pemphigus, is an autosomal dominant skin condition that affects the adhesion of epidermal keratinocytes. Although the initial manifestation of flaccid vesicles on erythematous or normal skin in flexure sites frequently goes unnoticed, large, macerated, exudative plaques of superficial erosions with crusting are observed at the time of diagnosis. There is no specific treatment for HHD, and most cases are symptomatically supported. However, infrared laser ablation has been somewhat helpful. We present a case successfully treated with fractional CO2 laser showing a long-term favourable outcome and no adverse effects. Thus, this modality could be an alternative to full ablation for this condition. 相似文献
2.
3.
4.
5.
María Cabrerizo Gloria Trallero María José Pena Amaia Cilla Gregoria Megias Carmen Mu?oz-Almagro Eva Del Amo Diana Roda Ana Isabel Mensalvas Antonio Moreno-Docón Juan García-Costa Nuria Rabella Manuel Ome?aca María Pilar Romero Sara Sanbonmatsu-Gámez Mercedes Pérez-Ruiz María José Santos-Mu?oz Cristina Calvo And the study group of “Enterovirus parechovirus infections in children under ?years-old Spain” PI- 《European journal of pediatrics》2015,174(11):1511-1516
6.
Toneva Diana H. Nikolova Silviya Y. Tasheva-Terzieva Elena D. Zlatareva Dora K. Lazarov Nikolai E. 《International journal of legal medicine》2022,136(6):1851-1863
International Journal of Legal Medicine - Sex identification is a primary step in forensic analysis of skeletal remains. The accuracy of sex estimation methods greatly depends on the sexual... 相似文献
7.
The etiology of obesity is multifactorial and still unclear. Genetic factors play a significant role and include several gene candidates: polymorphisms of genes for ss(2)-adrenoreceptor, resistin, estrogen receptor-a and peroxisome proliferator-activated receptor-gamma. Moreover, peptides regulating hunger and satiety, e.g. leptin, galanin, cholecystokinin and neuropeptide Y, and altered nutritional patterns have been implicated. Also, factors associated with aging, e.g. decreased levels of growth hormone and dehydroepiandrosterone, and the activity of the sympathetic nervous system (resting metabolism and thermogenesis) cannot be disregarded. Participation of the sex steroids and inflammatory factors has also been postulated in the etiology of obesity. Three phenotypes of obesity are postulated; however, the visceral (abdominal) phenotype is typical of postmenopausal women and is characterized by several metabolic disorders with high risks of diabetes mellitus type 2 and cardiovascular disease. On the basis of personal experience and data from evidence-based medicine, diagnostic-therapeutic algorithms of climacteric obesity are presented. 相似文献
8.
Long-term neurotoxicity of chlorpyrifos: spatial learning impairment on repeated acquisition in a water maze. 总被引:2,自引:0,他引:2
Fernando Ca?adas Diana Cardona Eva Dávila Fernando Sánchez-Santed 《Toxicological sciences》2005,85(2):944-951
Organophosphate compounds are cholinesterase inhibitors widely used in agriculture, industry, household products, and even as chemical weapons. Their major mechanism of acute toxic action is the inhibition of acetylcholinesterase, which is responsible for the degradation of the neurotransmitter acetylcholine. An organophosphorus ester-induced chronic neurotoxicity (OPICN) syndrome has been proposed. The OPICN syndrome could result from both long-term exposure to subclinical doses of OPs and after acute poisoning. Development of animal models for the cognitive decline are required and could later help to elucidate the mechanisms involved in this long-term effect on the central nervous system. Previously, we have found performance decrements in a four-trial repeated acquisition spatial task in a water maze. The present study includes two experiments to extend the long-term behavioral effects observed. Rats were injected either once or twice with chlorpyrifos (CPF) and then tested months after in a two-trial repeated acquisition task in a water maze. Our results confirm and extend the long-term behavioral effects of subcutaneous administration of CPF. The two treatments used produced performance decrements that suggest functional central nervous system alterations. 相似文献
9.
10.
Sherry X Yang Richard M Simon Antoinette R Tan Diana Nguyen Sandra M Swain 《Clinical cancer research》2005,11(17):6226-6232
PURPOSE: To delineate gene expression patterns and profile changes in metastatic tumor biopsies at baseline and 1 month after treatment with the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor erlotinib in patients with metastatic breast cancer. EXPERIMENTAL DESIGN: Patients were treated with 150 mg of oral erlotinib daily. Gene expression profiles were measured with Affymetrix U133A GeneChip and immunohistochemistry was used to validate microarray findings. RESULTS: Estrogen receptor (ER) status by immunohistochemistry is nearly coincided with the two major expression clusters determined by expression of genes using unsupervised hierarchical clustering analysis. One of 10 patients had an EGFR-positive tumor detected by both microarray and immunohistochemistry. In this tumor, tissue inhibitor of metalloproteinases-3 and collagen type 1 alpha 2, which are the EGF-down-regulated growth repressors, were significantly increased by erlotinib. Gene changes in EGFR-negative tumors are those of G-protein-linked and cell surface receptor-linked signaling. Gene ontology comparison analysis pretreatment and posttreatment in EGFR-negative tumors revealed biological process categories that have more genes differentially expressed than expected by chance. Among 495 gene ontology categories, the significant differed gene ontology groups include G-protein-coupled receptor protein signaling (34 genes, P = 0.002) and cell surface receptor-linked signal transduction (74 genes, P = 0.007). CONCLUSIONS: ER status reflects the major difference in gene expression pattern in metastatic breast cancer. Erlotinib had effects on genes of EGFR signaling pathway in the EGFR-positive tumor and on gene ontology biological process categories or genes that have function in signal transduction in EGFR-negative tumors. 相似文献