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排序方式: 共有80条查询结果,搜索用时 15 毫秒
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Kazimierz O. Wrzeszczynski Vanessa Felice Avinash Abhyankar Lukasz Kozon Heather Geiger Dina Manaa Ferrah London Dino Robinson Xiaolan Fang David Lin Michelle F. Lamendola-Essel Depinder Khaira Esra Dikoglu Anne-Katrin Emde Nicolas Robine Minita Shah Kanika Arora Olca Basturk Vaidehi Jobanputra 《The Journal of molecular diagnostics : JMD》2018,20(6):822-835
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H. S. Khaira D. Rittoo R. K. Vohra S. R. Smith 《Annals of the Royal College of Surgeons of England》2001,83(3):154-157
Finger discoloration may result from recognized conditions affecting upper limb vasculature. We describe 11 patients who presented with acute pain, swelling and blue/purple discoloration in a finger. This benign condition mimicked digital ischaemia. There were 9 women and 2 men. The episode usually started with an ache/pain in the finger followed 2-3 h later by a blue/purple discoloration primarily on the volar aspect but always sparing the tip. This completely resolved after 4-7 days with no residual deficit. There was no history of trauma. Four patients had had previous episodes--2 had been started on warfarin. There was no family history and only one gave a history of spontaneous bruising of her legs. Examination of all patients--pulse rate, blood pressure, cardiac and subclavian artery auscultation and digital artery Doppler insonation--was normal. All patients had normal full blood counts, CRP, vasculitis screen and clotting (except those on warfarin). Six similar cases, all women, were reported in 1982. There was no common aetiological factor other than sex. Although of no prognostic significance, the condition is likely to concern patients and doctors in primary care. The discoloration is, however, clearly of a different distribution to that in an ischaemic finger where the tip of the digit is involved. 相似文献
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Ambar Khaira Soumita Bagchi Alok Sharma Amar Mukund Sandeep Mahajan Dipankar Bhowmik Amit K. Dinda Sanjay K. Agarwal 《Clinical and experimental nephrology》2009,13(4):392-396
Renal transplant recipients are prone to a variety of infections due a persistent immunodepleted state. Incidence of tuberculosis
in this population is much higher compared with the general population. While pulmonary tuberculosis still remains the commonest
form in this population, renal allograft tuberculosis is very rare. We report two cases of isolated allograft tuberculosis
and one case of allograft tuberculosis with coexistent pleuro-pulmonary and bone marrow involvement. All three cases had presented
with pyrexia of unknown origin, wherein despite extensive investigations the cause was not found. In two cases the diagnosis
was confirmed on histology. Two cases responded to non-rifampicin-based modified antitubercular treatment and one to conventional
four-drug Rifampicin-based regimen. Graft function improved in two cases while in one case the graft was lost. Tuberculosis
involving the renal allograft is a potential cause for graft dysfunction/loss and requires a high index of suspicion for diagnosis.
Timely detection and early institution of therapy can help save the renal allograft. 相似文献
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Khaira A Rathi OP Mahajan S Sharma A Dinda AK Tiwari SC 《Clinical and experimental nephrology》2008,12(1):79-81
A 14-year-old girl presented with a 10-year history of a large crusted plaque over the right thigh for 10 years and small
reddish plaque over the left upper back for 3 months. On routine evaluation, she was found to have hematuria. Skin biopsy
from the lesion was suggestive of skin tuberculosis (lupus vulgaris), and kidney biopsy showed features of IgA nephropathy
(IgAN). Fine-needle aspiration from the inguinal lymph node was consistent with granulomatous disease. The patient has been
on anti-tubercular treatment, and the hematuria has subsided. 相似文献
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Vascular endothelial growth factor,its receptor KDR/Flk-1, and pituitary tumor transforming gene in pituitary tumors 总被引:34,自引:0,他引:34
McCabe CJ Boelaert K Tannahill LA Heaney AP Stratford AL Khaira JS Hussain S Sheppard MC Franklyn JA Gittoes NJ 《The Journal of clinical endocrinology and metabolism》2002,87(9):4238-4244
Pituitary tumorigenesis is a poorly understood process involving dysregulation of the cell cycle, proliferation, and angiogenesis. The novel securin pituitary tumor transforming gene (PTTG) disrupts cell division and stimulates fibroblast growth factor (FGF)-2-mediated angiogenesis. We investigated expression of the angiogenic vascular endothelial growth factor (VEGF) and its receptor KDR/Flk-1 in 103 human pituitary tumors, and we assessed functional relationships between these genes in vitro. Nonfunctioning tumors (n = 81) demonstrated markedly raised VEGF mRNA (3.2-fold, P < 0.05) and protein concentrations, compared with normal pituitaries (n = 10). KDR was also highly induced in nonfunctioning tumors (14-fold, P < 0.001, n = 78) as well as in the whole cohort of pituitary tumors, compared with normal pituitary samples (14-fold, P < 0.0001, n = 100). In vitro, PTTG induced VEGF, but not KDR, expression in fetal neuronal NT2 cells (2.7-fold, P < 0.001, n = 8), MCF-7 breast carcinoma cells (1.9-fold, P = 0.03, n = 10), and choriocarcinoma JEG-3 cells (P = 0.0002, n = 8). A mutated PTTG construct that cannot be phosphorylated showed identical VEGF up-regulation (2.9-fold, P < 0.001, n = 8) in NT2 cells, compared with wild-type PTTG, but a further mutated construct with abrogation of the key protein:protein interaction domain of PTTG resulted in a significant reduction in VEGF stimulation, compared with wild-type (0.37-fold reduction, P < 0.001, n = 8). FGF-2 findings mirrored those of VEGF, although antibody depletion of secreted FGF-2 in the cell medium failed to influence VEGF up-regulation by PTTG. Overall, our findings implicate altered VEGF and KDR signaling in pituitary tumorigenesis, and we propose that PTTG stimulation of FGF-2 and VEGF expression in the presence of up-regulated growth factor receptors may account for angiogenic growth and progression of human pituitary tumors. 相似文献
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Ambar Khaira Ankur Gupta Devendra S. Rana Ashwini Gupta Anil Bhalla Dinesh Khullar 《International urology and nephrology》2009,41(4):959-966