全文获取类型
收费全文 | 3464篇 |
免费 | 178篇 |
国内免费 | 40篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 96篇 |
妇产科学 | 113篇 |
基础医学 | 350篇 |
口腔科学 | 79篇 |
临床医学 | 721篇 |
内科学 | 638篇 |
皮肤病学 | 27篇 |
神经病学 | 218篇 |
特种医学 | 200篇 |
外科学 | 346篇 |
综合类 | 60篇 |
一般理论 | 1篇 |
预防医学 | 253篇 |
眼科学 | 75篇 |
药学 | 224篇 |
中国医学 | 3篇 |
肿瘤学 | 263篇 |
出版年
2021年 | 45篇 |
2020年 | 27篇 |
2019年 | 25篇 |
2018年 | 55篇 |
2017年 | 32篇 |
2016年 | 44篇 |
2015年 | 56篇 |
2014年 | 84篇 |
2013年 | 115篇 |
2012年 | 156篇 |
2011年 | 133篇 |
2010年 | 106篇 |
2009年 | 111篇 |
2008年 | 137篇 |
2007年 | 126篇 |
2006年 | 123篇 |
2005年 | 105篇 |
2004年 | 115篇 |
2003年 | 100篇 |
2002年 | 102篇 |
2001年 | 105篇 |
2000年 | 89篇 |
1999年 | 91篇 |
1998年 | 112篇 |
1997年 | 110篇 |
1996年 | 93篇 |
1995年 | 80篇 |
1994年 | 61篇 |
1993年 | 63篇 |
1992年 | 61篇 |
1991年 | 80篇 |
1990年 | 66篇 |
1989年 | 59篇 |
1988年 | 81篇 |
1987年 | 54篇 |
1986年 | 59篇 |
1985年 | 59篇 |
1984年 | 39篇 |
1983年 | 32篇 |
1982年 | 25篇 |
1981年 | 24篇 |
1980年 | 23篇 |
1979年 | 43篇 |
1978年 | 34篇 |
1977年 | 26篇 |
1974年 | 28篇 |
1973年 | 34篇 |
1971年 | 32篇 |
1970年 | 21篇 |
1968年 | 22篇 |
排序方式: 共有3682条查询结果,搜索用时 15 毫秒
1.
Albert De Decker Rosalie Fergusson Benjamin Ondruschka Niels Hammer Johann Zwirner 《Clinical anatomy (New York, N.Y.)》2020,33(4):522-529
For 50 years now, sacrospinous ligament fixation (SSLF) has been used to treat pelvic organ prolapse consequent on altered integrity of the pelvic myofascial structures. It is usually performed vaginally, but it has recently been performed laparoscopically through either an anterior or a posterior approach, with the broad ligament as a landmark to differentiate the two. In the present study, these two laparoscopic approaches were assessed using Thiel-embalmed cadavers. The anterior and posterior approaches were compared in terms of the closest distance to anatomical structures at risk, including pelvic viscera, the obturator nerve, and vascular structures. The posterior approach was more often closer to the investigated vessels and the rectum. The obturator nerve and the ureter were close to both the anterior and posterior approaches. The urinary bladder was closer using the anterior approach. From an anatomical standpoint, therefore, the anterior laparoscopic approach for SSLF is more likely to cause injury to the urinary bladder, whereas the posterior approach is more prone to causing rectal and vessel injuries. This study illustrates, from a basic science perspective, the importance of combining fascia research, novel endoscopic or minimally invasive surgical exposures informed by anatomy, and contemporary trends in gynecology in order to improve patient outcomes. Clin. Anat. 33:522–529, 2020. © 2019 Wiley Periodicals, Inc. 相似文献
2.
3.
Gina Kearney MSN RN CS AHN-BC JeMe Cioppa-Mosca PT MBA Margaret G. E. Peterson Ph.D C. Ronald MacKenzie MD 《HSS journal》2007,3(2):198-201
In an outpatient rehabilitation setting, both patients’ use and therapists’ knowledge of complementary and alternative medicine
(CAM) varies widely. Based on this observation and a recognition of CAM as an emerging practice area for rehabilitation professionals,
it was felt that a thorough and consistent approach to the education and orientation of physical therapists to the world of
CAM and integrative care was needed. This special interest paper will describe one center’s approach, development, and use
of a unique and comprehensive training manual designed to provide both a structured and standardized approach for educating
physical therapists about CAM and related therapeutic modalities. This innovative teaching tool allows for multiple methods
of content delivery within a multidisciplinary format and can be used for those who practice currently or desire to practice
in an integrative care environment. 相似文献
4.
Yew Kuang Cheng Paul A Decker Megan M O'Byrne Catherine R Weiler 《Annals of allergy, asthma & immunology》2006,97(3):306-311
BACKGROUND: There are limited studies of large cohorts of patients with specific polysaccharide antibody deficiency (SPAD) syndrome. OBJECTIVE: To study the clinical and laboratory characteristics of patients with specific polysaccharide antibody deficiency syndrome. METHODS: We retrospectively studied 75 patients with total IgG levels of at least 500 mg/dL and fewer than 9 of 12 responses to vaccination with pneumococcal vaccine polyvalent. Exclusion criteria included an IgG level less than 500 mg/dL, established immunodeficiency syndrome, and secondary immunodeficiency. RESULTS: The most common clinical presentation was frequent infections (n = 69; 92%), including sinusitis (n = 53; 77%), pneumonia (n = 29; 42%), ear infections (n = 18; 26%), and bronchitis (n = 19; 28%). Other presentations were systemic infections (n = 5; 7%), autoimmune or rheumatic diseases (n = 6; 8%), and chronic diarrhea (n = 4; 5%). The median IgG2 level of patients with no response to pneumococcal vaccine polyvalent tended to be lower than that of patients with at least 1 response (150 vs 193 mg/dL, respectively; P = .06). There was no association between total IgG level (categorized as 500-600 or > or = 600 mg/dL) and frequency of infection (P = .43). Patients with fewer responses to pneumococcal vaccine polyvalent and a higher frequency of infections were more likely to receive intravenous immunoglobulin (IVIG) therapy (P = .01 and .003, respectively). Treatment with IVIG significantly reduced the number of infections (P < .001). CONCLUSION: Patients with no response to pneumococcal vaccine polyvalent tended to have lower IgG2 levels; those with fewer responses were more likely to receive IVIG therapy. 相似文献
5.
Dr. M. Decker 《Basic research in cardiology》1940,6(1-3):75-82
Zusammenfassung In Versuchen am Herzspitzen- und Herzstreifenpräparat und am ganzen herausgeschnittenen Herzen des Frosches wird bewiesen, daß für den Anstieg der einphasischen Aktionsspannungskurve nicht nur die Entwicklung des Aktionspotentials im einzelnen Herzmuskelelement maßgebend ist, sondern auch die Errguungsleitung.Mit 4 Abbildungen.Ausgeführt mit Mitteln der W. G. Kerckhoff-Stiftung 1938/39. Abgeschlossen am 1. September 1939. 相似文献
6.
7.
8.
R Sterner H Decker 《Proceedings of the National Academy of Sciences of the United States of America》1994,91(11):4835-4839
The Bohr effect describes the usually negative coupling between the binding of oxygen and the binding of protons to respiratory proteins. It was first described for hemoglobin and provides for an optimal oxygen supply of the organism under changing physiological conditions. Our measurements of both oxygen and proton binding to the 24-meric tarantula hemocyanin establish the unusual case where a respiratory protein binds protons at low degrees of oxygenation but releases protons at high degrees of oxygenation. In contrast to what is observed with hemoglobin and other respiratory proteins, this phenomenon amounts to the inversion of the Bohr effect in the course of an oxygen-binding curve at a given pH value. Therefore, protons in spider blood can act either as allosteric activators or as allosteric inhibitors of oxygen binding, depending on the degree of oxygenation of hemocyanin. These functional properties of tarantula hemocyanin, which cannot be explained by classical allosteric models, require at least four different conformational states of the subunits. Inspection of the known x-ray structures of closely related hemocyanins suggests that salt bridges between completely conserved histidine and glutamate residues located at particular intersubunit interfaces are responsible for the observed phenomena. 相似文献
9.
LEE JS IM HH JUNG Y JUNG IS JANG JY CHUN YK CHO YD KIM JO CHO JY KIM YS SHIM CS & KIM BS 《Neurogastroenterology and motility》2006,18(6):493-494
Background: Recent development of extracorporeal magnetic stimulation (ECMS) which uses current‐changing magnetic fields allows the induction of electrical stimulation in the desired deep tissue. Recent study showed the sacral nerve stimulation reduces corticoanal excitability that may play a functional role in anal continence mechanisms. Preliminary study shows that ECMS of sacral nerve can modify pelvic floor function and expel rectal balloon in patients with pelvic floor dyssynergia (PFD). Aims: To evaluate the effect of ECMS compared with biofeedback therapy (BF) in patients with PFD. Methods and Materials: Thirty‐eight patients who fulfilled Rome II criteria for PFD by colon transit time and anorectal function tests, were randomly treated with 8 sessions of ECMS (2/weeks; n = 19) at prone position or BF (2/weeks; n = 19) at sitting position. Stimulation parameters were set at 50–80% of maximum intensity, 10 and 50 Hz frequency, 3 s burst length with 3 and 6 s off using arm‐typed stimulator (BioCom‐1000, Mcube Co., Korea). Symptom scores for constipation with/without anorectal function test were repeatedly measured after each treatment. Response was defined as 50% or more decreased symptom score after treatment (partial response: 30–50%, poor: <30%). Results: Fifteen patients (age 49.1 ± 13.4 years, mean ± SD; 4 men) completed 8 session of BF and 14 patients (54.5 ± 17.6 years, 3 men) completed 8 session of ECMS. Four patients of BF group discontinued treatment due to unsatisfactory therapeutic effect (n = 1) and withdrew consent (n = 3) and 5 patients of ECMS group discontinued treatment because of same reasons (n = 1, 4). Total symptom scores were significantly decreased after treatment of 8 session in both treatment groups (13.4 ± 6.6 vs. 4.3 ± 4.0 for BF, p = 0.009; 14.9 ± 5.6 vs. 3.4 ± 4.0 for ECMS, p < 0.001). Bowel movements per week were also significantly increased after treatment in both groups (median 2 vs. 7 for BF, p = 0.035; median 2 vs. 7 for ECMS, p = 0.008). Thirteen out of 15 patients showed response in BF group and 12 out of 14 showed good response in ECMS group. No adverse effects in both groups. Conclusions: ECMS is as effective as BF for the treatment of PFD. Long‐term effect of ECMS for the patients with pelvic floor dyssynergia need to be evaluated in the near future. 相似文献
10.
Metabolic products of microorganisms. 255. Nikkomycins Wz and Wx, new chitin synthetase inhibitors from Streptomyces tendae 总被引:3,自引:0,他引:3
H Decker F Walz C Bormann H Z?hner H P Fiedler H Heitsch W A K?nig 《The Journal of antibiotics》1990,43(1):43-48
Two new dipeptidyl nikkomycins of the Z and X type were isolated from the culture broth of Streptomyces tendae TU 901/395-11/32 and characterized. They show a variation in the amino acid moiety of the molecule. Nikkomycin Wz is composed of L-tyrosine and 5-amino-5-deoxy-D-allo-furanuronic acid N-glycosidally bound to uracil, whereas nikkomycin Wx is composed of L-tyrosine and 5-amino-5-deoxy-D-allo-furanuronic acid N-glycosidally bound to 4-formyl-4-imidazolin-2-one. The new nikkomycins are good inhibitors of chitin synthetase from Coprinus cinereus but they did not inhibit growth of fungi and yeasts. 相似文献