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排序方式: 共有67条查询结果,搜索用时 15 毫秒
1.
Sekwon Jang Anna Prizment Tufia Haddad Kim Robien DeAnn Lazovich 《Journal of cancer survivorship》2011,5(2):115-122
Purpose
To examine the association of smoking and quality of life (QOL) among survivors of breast, colorectal, or endometrial cancers. 相似文献2.
Lazovich D Forster J Sorensen G Emmons K Stryker J Demierre MF Hickle A Remba N 《Archives of pediatrics & adolescent medicine》2004,158(9):918-924
BACKGROUND: Indoor tanning is a popular behavior that may increase skin cancer risk. OBJECTIVE: To examine characteristics associated with use or intention to use indoor tanning among adolescents. METHODS: A telephone interview was conducted with 1273 adolescents, aged 14 to 17 years, in the Minneapolis-St Paul, Minn, and Boston, Mass, metropolitan areas. Questions included demographic and phenotypic characteristics, knowledge, attitudes, social factors, use of indoor tanning, and intention to tan indoors. RESULTS: Twelve percent of boys and 42% of girls had tanned indoors. Among nontanners, 22.4% planned to start, and 77.2% of tanners planned to continue tanning indoors. Nontanners and tanners at risk for future indoor tanning use were each significantly more likely to be female, less likely to use sun protection, less knowledgeable about skin cancer risks, more likely to agree that tans were attractive, and more strongly influenced by social factors compared with their low-risk counterparts. CONCLUSIONS: Our data suggest that intention to tan indoors may identify a group of adolescents at risk for adopting the behavior; prospective studies are needed for confirmation. 相似文献
3.
Amphotericin B Colloidal Dispersion Combined with Flucytosine with or without Fluconazole for Treatment of Murine Cryptococcal Meningitis 总被引:1,自引:3,他引:1
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DeAnn M. Diamond Madeline Bauer Barbra E. Daniel Mary Ann E. Leal Debra Johnson Byron K. Williams Ann M. Thomas James C. Ding Laura Najvar J. Richard Graybill Robert A. Larsen 《Antimicrobial agents and chemotherapy》1998,42(3):528-533
Studies with animals and in vitro studies have demonstrated that flucytosine plus amphotericin B or fluconazole has significantly improved mycologic activity against meningitis caused by Cryptococcus neoformans compared to the activity of amphotericin B or fluconazole used alone. However, few doses have been tested in combination. This study evaluated the antifungal efficacy of amphotericin B colloidal dispersion (ABCD) combined with flucytosine with and without fluconazole in a murine model of cryptococcal meningitis. The following dosages were tested: ABCD at 0 to 12.5 mg/kg of body weight given intravenously 3 days/week, flucytosine at 0 to 110 mg/kg/day, and fluconazole at 0 to 50 mg/kg/day. Meningitis was established in male BALB/c mice by intracerebral injection of C. neoformans. Treatment with flucytosine with or without fluconazole dissolved in the sole source of drinking water was started on day 2; animals were sacrificed at 16 days, and the numbers of fungal colonies in the brain were quantified. A survival rate of 100% was achieved with ABCD plus flucytosine without fluconazole; however, the addition of fluconazole was required to prevent weight loss (P < 0.00001) and to achieve the maximum antifungal effect (P < 0.00001). The only region of dose combinations for which the 99% confidence intervals were less than 100 CFU/g of brain was defined by ABCD at 5.0 to 7.5 mg/kg combined with flucytosine at 20 to 60 mg/kg/day and fluconazole at 30 to 40 mg/kg/day. The triple combination of ABCD plus flucytosine and fluconazole was necessary to achieve the greatest antifungal activity. 相似文献
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Vitamin D intake and breast cancer risk in postmenopausal women: the Iowa Women’s Health Study 总被引:2,自引:0,他引:2
Vitamin D, a prosteroid hormone with anti-proliferative and pro-differentiation activity, is thought to act as a cancer chemopreventive
agent. This study evaluated the association between vitamin D intake and breast cancer risk among women in a large prospective
cohort study. A total of 34,321 postmenopausal women who had completed a questionnaire that included diet and supplement use
were followed for breast cancer incidence from 1986 to 2004. Adjusted relative risks (RR) for breast cancer were calculated
for dietary, supplemental, and total vitamin D intake among all women. The adjusted RR of breast cancer for women consuming
>800 IU/day versus <400 IU/day total vitamin D was 0.89 (95% CI: 0.77–1.03). RRs were stronger among women with negative than
positive ER or PR status. The association of high vitamin D intake with breast cancer was strongest in the first 5 years after
baseline dietary assessment (RR = 0.66; 95% CI: 0.46–0.94 compared with lowest-intake group), and diminished over time. Changes
in vitamin D intake over time might have contributed to the diminished association observed in later years. Vitamin D intake
of >800 IU/day appears to be associated with a small decrease in risk of breast cancer among postmenopausal women. Studies
evaluating all sources of vitamin D, especially sun exposure, are needed to fully understand the association between vitamin
D and breast cancer risk. 相似文献
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Mosunmoluwa Oyenuga Robert A. Vierkant Charles F. Lynch Thomas Pengo Lori S. Tillmans James R. Cerhan Timothy R. Church DeAnn Lazovich Kristin E. Anderson Paul J. Limburg Anna E. Prizment 《Molecular carcinogenesis》2021,60(1):15-24
Tumor‐infiltrating lymphocytes in colorectal cancer (CRC) predict better survival. However, associations between T‐lymphocyte count in histologically normal tissues from patients with CRC and survival remain uncertain. We examined associations of CD3+ T‐cells in colorectal tumor and histologically normal tissues with CRC‐specific and all‐cause mortality in the prospective Iowa Women's Health Study. Tissue microarrays were constructed using paraffin‐embedded colorectal tissue samples from 464 women with tumor tissues and 314 women with histologically normal tissues (55–69 years at baseline) diagnosed with incident CRC from 1986 to 2002 and followed through 2014 (median follow‐up 20.5 years). Three tumor and two histologically normal tissue cores for each patient were immunostained using CD3+ antibody and quantified, and the counts were averaged across the cores in each tissue. Cox proportional hazards regression estimated hazard ratios (HR) and 95% confidence interval (CI) for CRC‐specific and all‐cause mortality. After adjustment for age at diagnosis, body mass index, smoking status, tumor grade, and stage, HRs (95% CI) for the highest versus lowest tertile of tumor CD3+ score were 0.59 (0.38–0.89) for CRC‐specific mortality and 0.82 (0.63–1.05) for all‐cause mortality; for histologically normal CD3+ score, the corresponding HRs (95% CI) were 0.47 (0.19–1.17) and 0.50 (0.27–0.90), respectively. The CD3+ score combining the tumor and histologically normal scores was inversely associated with CRC‐specific and all‐cause mortality. Although the association between tumor CD3+ score and all‐cause mortality was not significant, both higher CD3+ T‐lymphocyte counts in tumor and histologically normal scores tended to be associated with lower CRC‐specific and all‐cause mortality. 相似文献
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