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1.
JANE G. KHOURY MD RAMINDER SALUJA MD MITCHEL P. GOLDMAN MD 《Dermatologic surgery》2008,34(8):1062-1069
BACKGROUND Botulinum toxin type A (BTX) is commonly used in combination therapy, and it has been reported that periocular BTX treatment enhances the aesthetic improvements attained with intense pulsed light (IPL).
OBJECTIVE The objective was to evaluate if intradermal BTX treatment of the cheeks also enhances the efficacy of IPL.
METHODS AND MATERIALS Fifteen females enrolled in this prospective, randomized, double-blind, split-face study (14 completed, 1 lost to follow-up). All received standard IPL treatment and were randomly assigned to receive eight 0.1-mL intradermal injections of BTX (BOTOX Cosmetic, Allergan) in one cheek (8 U total dose) and eight injections of saline in the contralateral cheek. Small wrinkles and fine lines, erythema, hyperpigmentation, apparent pore size, skin texture, and overall appearance were evaluated for 8 weeks.
RESULTS A significantly higher proportion of patients showed improvement in small wrinkles and fine lines with IPL plus BTX than IPL plus saline—93% versus 29% at Week 4 ( p =.003). Adjunctive BTX also achieved a greater degree of improvement in erythema (although statistical significance was not achieved). Other efficacy measures showed comparable improvements with both regimens.
CONCLUSION The adjunctive use of BTX enhances the improvement in small wrinkles and fine lines, and possibly erythema, achieved with IPL alone. 相似文献
OBJECTIVE The objective was to evaluate if intradermal BTX treatment of the cheeks also enhances the efficacy of IPL.
METHODS AND MATERIALS Fifteen females enrolled in this prospective, randomized, double-blind, split-face study (14 completed, 1 lost to follow-up). All received standard IPL treatment and were randomly assigned to receive eight 0.1-mL intradermal injections of BTX (BOTOX Cosmetic, Allergan) in one cheek (8 U total dose) and eight injections of saline in the contralateral cheek. Small wrinkles and fine lines, erythema, hyperpigmentation, apparent pore size, skin texture, and overall appearance were evaluated for 8 weeks.
RESULTS A significantly higher proportion of patients showed improvement in small wrinkles and fine lines with IPL plus BTX than IPL plus saline—93% versus 29% at Week 4 ( p =.003). Adjunctive BTX also achieved a greater degree of improvement in erythema (although statistical significance was not achieved). Other efficacy measures showed comparable improvements with both regimens.
CONCLUSION The adjunctive use of BTX enhances the improvement in small wrinkles and fine lines, and possibly erythema, achieved with IPL alone. 相似文献
2.
JAMES MALONEY MARTIN MASTERSON DIRAR KHOURY RICHARD TROHMAN BRUCE WILKOFF TONY SIMMONS VICTOR MORANT LON CASTLE 《Pacing and clinical electrophysiology : PACE》1991,14(2):280-285
Records of 105 patients, who received an automatic implantable Cardioverter defibrillator (AICD), were studied to investigate the causes of spontaneous AJCD discharges and to correlate the symptoms with the arrhythmias triggering AJCD discharges. During a follow-up period of 13 ± 8 months, 46/105 (44%) patients had 566 spontaneous AICD discharges. A total of 101 discharges were documented with Holter monitoring in 23 patients. In this study group, there were 8 (8%) AICD discharges for 5 episodes of ventricular fibrillation, and 68 (67%) discharges for 63 episodes of sustained ventricular tachycardia. Patients lost consciousness in all episodes of ventricular fibrillation, but were symptomatic prior to only 36 (53%) discharges in ventricular tachycardia. Non-sustained ventricular tachycardia persisting for a period of 7,5 ± 2 seconds resulted in 20 AICD discharges; patients were symptomatic prior to 13 (65%) discharges. Supraventricular tachycardias triggered three discharges. One patient had two spurious discharges during sinus rhythm. In conclusion, most of the spontaneous AICD discharges were appropriate for the detected rhythms, but only clinically appropriate for the management of arrhythmias in 75% of the cases. A significant portion of the patients with sustained or nonsustained ventricular tachycardias triggering AICD discharges were asymptomatic prior to discharge, which requires further assessment of the physiology of the arrhythmia as a component of the detection algorithm. 相似文献
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D. THEODORESCU A. BALCOM C.R. SMITH G.A. McLORIE B.M. CHURCHILL A.E. KHOURY 《The Journal of urology》1998,159(5):1708-1711
Purpose
Residual urethral defects after failed hypospadias surgery present difficulties in reconstruction. In these situations, repair using vascularized tissue flaps remains ideal, yet challenging. In order to offer more surgical alternatives in these cases, the use of vascularized tunica vaginalis flaps as urethral replacements has recently been established in an animal model. We undertook the following studies to further define the role of tunica vaginalis in urethral reconstruction.Materials and Methods
A vascularized flap of tunica vaginalis was used to replace an experimentally created 25-30 mm. gap in the anterior urethra of 26 rabbits, either as an onlay or tube flap. A control group consisting of 7 animals underwent only a segmental anterior urethral resection and primary re-anastomosis.Results
Satisfactory urethral healing occurred in all control animals that survived the procedure. All 8 animals which had tunica vaginalis tube flap reconstruction underwent contracture of the neourethra probably secondary to the presence of striated cremasteric muscle elements brought with the tunica during mobilization. All 16 animals available for long term study in the onlay flap group had excellent flap viability and 100% urethral patency rates. The mesothelial lining of the tunica was seen to be replaced by a stratified epithelial lining similar to the urothelial lining of the native urethra.Conclusion
The tunica vaginalis is a viable alternative to other tissues presently used for urethral replacement and can be used successfully as a vascularized onlay flap. 相似文献7.
K. R. PEEL Consultant Gynaecologist G. G. KHOURY Lecturer in Radiotherapy C. A. F. JOSLIN Professor in Radiotherapy P. J. O'DONOVAN Senior Registrar in Obstetrics/Gynaecology H. MGAYA Research Fellow in Gynaecological Oncology G. KEATES C. HEAD D. J. THOROGOOD 《BJOG : an international journal of obstetrics and gynaecology》1991,98(10):993-1000
8.
Effects of Internal Defibrillation on an Implanted Pacing System with Programmable Polarity 总被引:1,自引:0,他引:1
DIRAR S. KHOURY WEI-XI ZHU JUNICHI NITTA CARLOS RIZO-PATRON JAMES D. MALONEY 《Pacing and clinical electrophysiology : PACE》1995,18(1):188-193
Management of multiple cardiac arrhythmias in some patients with both an implantable cardioverter defibrillator (ICD) and a pacemaker has demonstrated several advantages. In such circumstances, it is imperative that pacemaker function and its programmed parameters be preserved following a deftbrillation shock. This article describes the effects encountered by a specific programmable polarity pacemaker (Relay® 294–03) when subjected to electrical defibrillation in a canine model. Three pacemakers were repeatedly tested in three separate dog experiments. Each pacemaker, with its leads implanted in the right atrium and the right ventricle, was subjected to a minimum total number of 24 high energy biphasic and monophasic shocks (600–700 V) delivered by a coexisting ICD system using three different defibrillating lead configurations. None of the pacemaker systems showed any failure in function; all pacemakers continued to function within preshock specification and conversion to unipolar pacing and/ or backup mode was not observed in any of the tests. Intracardiac electrical potentials measured directly off the ICD and the pacemaker leads, during a defibrillation shock (mean 566.6 V; 23.7 J), showed that potentials measured in a bipolar configuration (tip-ring: mean 21.0 V in atrium, 12.0 V in ventricle) were significantly less than potentials measured in a unipolar configuration (tip-can: mean 387.9 V in atrium, 394.0 V in ventricle; ring-can: mean 405.6 V in atrium, 395.4 V in ventricle). Our compatibility tests demonstrate that use of this programmable-polarity pacemaker in concert with an ICD system appears to be safe. Testing similar to the present study should be conducted prior to complete clinical acceptance of combined ICD and pacemaker implantation. 相似文献
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LEO C.T. FUNG BERNARD M. CHURCHILL GORDON A. McLORIE PETER G. CHAIT ANTOINE E. KHOURY 《The Journal of urology》1998,159(4):1326-1330
Purpose
The antegrade nephrostogram is an important tool in the evaluation of the upper urinary tract. However, the information currently provided by a nephrostogram is largely limited to anatomical details. To establish a meaningful pressure-flow parameter that may be incorporated into a routine nephrostogram, we evaluated the ureteral opening pressure (defined as the pressure at which contrast material is first seen beyond the suspected site of obstruction) and correlated these findings with the results of pressure-flow studies performed with an external infusion and/or furosemide induced diuresis.Materials and Methods
A total of 52 renal units were studied under a prospective pressure-flow study protocol. All patients had grade 3 or 4 hydronephrosis (Society of Fetal Urology classification) and patient age range was 0.2 to 12 years (median 1.1). The suspected sites of obstruction were the ureteropelvic and ureterovesical junctions in 42 and 10 renal units, respectively. With the patient under general anesthesia 22 gauge percutaneous nephrostomy needles were inserted. Pressure-flow studies with an external infusion and/or furosemide induced diuresis were then performed. As the renal pelvic pressure progressively increased during the course of the pressure-flow studies, the renal pelvic pressure at which contrast material was first seen to appear distal to the suspected site of obstruction was recorded as the ureteral opening pressure. Ureteral opening pressures were compared to the results of the pressure-flow studies.Results
With a positive test defined as renal pelvic pressure greater than 14 cm. water, positive ureteral opening pressures were associated with positive pressure-flow study results in 100% of the cases, regardless of which form of pressure-flow study was used or where the suspected site of obstruction was located. In contrast, negative ureteral opening pressures had specificities and negative predictive values of only 19 to 57%, depending on the form of the pressure-flow study and the suspected site of obstruction.Conclusions
An elevated ureteral opening pressure was 100% predictive of obstruction and may obviate the need for more elaborate pressure-flow analyses. However, if the ureteral pelvic pressure remained low, the possibility of a potentially significant obstruction could not be definitively eliminated and further evaluation was required. 相似文献10.
THERESA MAYES RD MICHELE M. GOTTSCHLICH PhD RD JANE KHOURY MS GLENND WARDEN MD 《Journal of the American Dietetic Association》1996,96(1):24-29
Objective The energy predictions of nine calculations for pediatric patients were compared with measured resting energy expenditure (MREE) by means of indirect calorimetry to determine the optimal means of energy projection in the burn population younger than 3 years of age.Methodology Nutritional sufficiency and maintenance of preburn weight were factors in the confirmation of energy needs. Demographic factors were also studied: preburn weight, percent burn, percent third-degree burn, and age. Group 1 consisted of 24 patients younger than 3 years of age (range=7 months to 2.6 years) with a percent burn of 30.6±2.0 and percent third-degree burn of 21.9±2.6. Group 2, consisting of 24 patients 5 to 10 years old matched by percent burn and percent third-degree burn, was included to determine whether differences between actual and projected needs were evident in older, prepubescent patients.Statistical analysis Analysis of variance was used to ascertain the most reliable multiplier for MREE needed to maintain at least 95% of preburn weight at discharge while ensuring adequate nutrition. Multiple regression analysis was used to determine the relationship between energy requirement and body weight, percent burn, and age. Results An additional 30% of MREE provided a consistent ratio of actual energy intake to required intake. MREE × 1.3 was used as a guide to study the existing calculations. For both groups, the four equations that predicted energy in healthy children most often underestimated MREE × 1.3, whereas the five formulas for children with burns tended to overpredict energy. Regression analysis yielded two new sets of equations using age, preburn weight, and percent burn (<3 YEARS=Mayes 1 [r2.71], 5 to 10 YEARS=Mayes 3 [r2=.70] or percent third-degree burn (<.3 YEARS=Mayes 2 [r2=.68], 5 to 10 YEARS=Mayes 4 [r2=.67]).Conclusions The application of a 30% factor to MREE is supported in burn patients younger than 10 years of age. Standard energy projections do not provide an accurate assessment of energy needs in the pediatric burn population; thus, two sets of equations that more closely predict energy needs are proposed. J Am Diet Assoc. 1996; 96:24-29. 相似文献