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排序方式: 共有272条查询结果,搜索用时 15 毫秒
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R O Darouiche R M Cadle G J Zenon M F Weinert R J Hamill M D Lidsky 《The Journal of rheumatology》1992,19(12):1991-1993
Rheumatic manifestations of histoplasmosis are uncommon. Polyarthritis or arthralgias may occur as a part of a sensitization process in primary acute histoplasmosis. Infectious arthritis may accompany disseminated histoplasmosis or occur as solitary monoarthritis. Treatment of the latter traditionally consists of surgical excision followed by amphotericin B. Reports of clinical experience with the newer triazole compounds in treating articular histoplasmosis are lacking. We describe a patient with solitary monoarticular histoplasmosis of the knee who was successfully treated with oral fluconazole and required no surgical intervention. Specific issues that pertain to clinical presentation and management of articular histoplasmosis are discussed. 相似文献
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Ceschinski H Henkes H Weinert HC Weber W Kühne D Monstadt H 《Bio-medical materials and engineering》2000,10(1):31-42
Guidewires for microcatheters used for the subselective catheterization of small vessels must meet high quality requirements in regard to handling, steerability, radiopacity and physical properties. The aim of this paper is to classify one of the factors that determine the physical and mechanical parameters of a number of existing microcatheter guidewires. A torsion-testing equipment for guidewires was devised. Nitinol wires were tested and compared with the austenitic stainless steel variants. 13 different commercial wires were tested. Tensile strength, shear modulus and wire diameter are the determining factors of the torsional rigidity of guidewires. By interpreting the measured torsional momentums various statements concerning the torsional rigidity of different wires can be made. The properties of guidewires are characteristic features of a system and friction and flexible strength examinations have to be carried out to design new variants of wires to meet the requirements of interventional physicians. 相似文献
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Irina Buckle Anthony Johnson Ingrid Leal Rojas Vicky Weinert David P. Sester Kristen Radford Camille Guillerey 《European journal of immunology》2023,53(6):2250118
Growing interest surrounds adoptive cellular therapies utilizing Natural Killer (NK) cells, which can be obtained from various sources, including umbilical cord blood (UCB) and adult peripheral blood (APB). Understanding NK cell receptor expression and diversity in such cellular sources will guide future therapeutic designs. We used a 20-color flow cytometry panel to compare unstimulated and cytokine-activated UCB and APB NK cells. Our analysis showed that UCB NK cells express slightly higher levels of the immune checkpoints PD-1, TIGIT, and CD96 compared to their APB counterparts. Unsupervised hierarchical clustering and dimensionality reduction analyses revealed enrichment in CD56neg as well as mature NKp46neg and CD56+CD16+ NK cell populations in UCB whereas CD57+ terminally differentiated NK cells with variable expression of KIRs and CD16 were found in APB. These populations were conserved following stimulation with IL-12, IL-15, and IL-18. Cytokine stimulation was associated with the downregulation of TIGIT and CD16 on multiple NK cell subsets in UCB and APB. Among UCB CD16− NK cell populations, TIGIT+ NK cells produced more IFN-γ than their TIGIT− counterparts. Our data demonstrate higher immune checkpoint expression on UCB NK cells compared to APB. However, the expression of TIGIT immune checkpoint is not indicative of NK cell exhaustion. 相似文献
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Thiele H Hambrecht R Lauer B Weinert M Mohr FW Schuler G 《The Journal of heart valve disease》2001,10(1):129-135
BACKGROUND AND AIM OF THE STUDY: Intraoperative swabs of heart valves are obtained regularly from patients undergoing heart valve surgery for infective endocarditis (IE) in order to confirm the preoperative diagnosis and to adjust the antibiotic regimen. The study aim was to assess the diagnostic value of intraoperative swabs of heart valves in IE. METHODS: A total of 83 patients was referred for surgical treatment of active IE between October 1994 and May 1999. Preoperatively, microorganisms were isolated using a minimum of two positive blood cultures; results were compared with those obtained from intraoperative heart valve swab cultures. RESULTS: Preoperatively, 73 patients (88%) had a positive blood culture, and 10 (12%) had culture-negative endocarditis. The intraoperative swab confirmed the preoperative diagnosis in 31 cases (37%). Bacteria were isolated in three of the ten patients with preoperative culture-negative IE. Despite positive histopathological findings in seven patients, no microorganisms were cultured either pre- or intraoperatively. Among the remaining 42 patients (51%) with active IE, 25 valve cultures were sterile and 17 valve swabs were presumed to be contaminated. CONCLUSION: In patients with active IE in whom the causative agent could be isolated and identified before surgery, intraoperative valve swabs did not contribute further to patient management. In isolating contaminants, the risk of inappropriate modification of the antibiotic regimen is imminent. The diagnostic validity in culture-negative IE appears negligible. 相似文献
9.
Effects of aging on left atrial reservoir, conduit, and booster pump function: a multi-institution acoustic quantification study 总被引:12,自引:0,他引:12 下载免费PDF全文
Spencer KT Mor-Avi V Gorcsan J DeMaria AN Kimball TR Monaghan MJ Perez JE Weinert L Bednarz J Edelman K Kwan OL Glascock B Hancock J Baumann C Lang RM 《Heart (British Cardiac Society)》2001,85(3):272-277
OBJECTIVE—To assess the feasibility of measuring left atrial (LA) function with acoustic quantification (AQ) and then assess the effects of age and sex on LA reservoir, conduit, and booster pump function.
PATIENTS AND SETTING—165 subjects without cardiovascular disease, 3-79 years old, were enrolled by six tertiary hospital centres.
INTERVENTIONS—Continuous LA AQ area data were acquired and signal averaged to form composite waveforms which were analysed off-line.
MAIN OUTCOME MEASURES—Parameters of LA performance according to age and sex.
RESULTS—Signal averaged LA waveforms were sufficiently stable and detailed to allow automated analysis in all cases. An age related increase in LA area was noted. LA reservoir function did not vary with age or sex. All parameters of LA passive and active emptying revealed a significant age dependency. Overall, the passive emptying phase accounted for 66% of total LA emptying ranging from 76% in the youngest to 44% in the oldest decade. LA contraction accounted for 34% of atrial emptying in all subjects combined with the older subjects being more dependent on atrial booster pump function. When adjusted for atrial size, there were no sex related differences in LA function.
CONCLUSIONS—LA reservoir, conduit, and booster pump function can be assessed with automated analysis of signal averaged LA area waveforms. As LA performance varies with age, establishment of normal values should enhance the evaluation of pathologic states in which LA function is important.
Keywords: aging; atrium; echocardiography 相似文献
PATIENTS AND SETTING—165 subjects without cardiovascular disease, 3-79 years old, were enrolled by six tertiary hospital centres.
INTERVENTIONS—Continuous LA AQ area data were acquired and signal averaged to form composite waveforms which were analysed off-line.
MAIN OUTCOME MEASURES—Parameters of LA performance according to age and sex.
RESULTS—Signal averaged LA waveforms were sufficiently stable and detailed to allow automated analysis in all cases. An age related increase in LA area was noted. LA reservoir function did not vary with age or sex. All parameters of LA passive and active emptying revealed a significant age dependency. Overall, the passive emptying phase accounted for 66% of total LA emptying ranging from 76% in the youngest to 44% in the oldest decade. LA contraction accounted for 34% of atrial emptying in all subjects combined with the older subjects being more dependent on atrial booster pump function. When adjusted for atrial size, there were no sex related differences in LA function.
CONCLUSIONS—LA reservoir, conduit, and booster pump function can be assessed with automated analysis of signal averaged LA area waveforms. As LA performance varies with age, establishment of normal values should enhance the evaluation of pathologic states in which LA function is important.
Keywords: aging; atrium; echocardiography 相似文献
10.
Goette A Hammwöhner M Bukowska A Scalera F Martens-Lobenhoffer J Dobrev D Ravens U Weinert S Medunjanin S Lendeckel U Bode-Böger SM 《International journal of cardiology》2012,154(2):141-146