全文获取类型
收费全文 | 1693篇 |
免费 | 198篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 62篇 |
妇产科学 | 34篇 |
基础医学 | 168篇 |
口腔科学 | 67篇 |
临床医学 | 216篇 |
内科学 | 394篇 |
皮肤病学 | 23篇 |
神经病学 | 106篇 |
特种医学 | 112篇 |
外科学 | 236篇 |
综合类 | 47篇 |
预防医学 | 179篇 |
眼科学 | 66篇 |
药学 | 84篇 |
肿瘤学 | 88篇 |
出版年
2020年 | 18篇 |
2019年 | 28篇 |
2018年 | 31篇 |
2017年 | 15篇 |
2016年 | 23篇 |
2015年 | 29篇 |
2014年 | 41篇 |
2013年 | 58篇 |
2012年 | 54篇 |
2011年 | 62篇 |
2010年 | 52篇 |
2009年 | 36篇 |
2008年 | 57篇 |
2007年 | 55篇 |
2006年 | 37篇 |
2005年 | 47篇 |
2004年 | 34篇 |
2003年 | 49篇 |
2002年 | 36篇 |
2001年 | 42篇 |
2000年 | 45篇 |
1999年 | 35篇 |
1998年 | 45篇 |
1997年 | 47篇 |
1996年 | 45篇 |
1995年 | 34篇 |
1994年 | 32篇 |
1993年 | 37篇 |
1992年 | 51篇 |
1991年 | 39篇 |
1990年 | 34篇 |
1989年 | 44篇 |
1988年 | 38篇 |
1987年 | 42篇 |
1986年 | 39篇 |
1985年 | 49篇 |
1984年 | 29篇 |
1983年 | 35篇 |
1982年 | 34篇 |
1981年 | 32篇 |
1979年 | 19篇 |
1978年 | 25篇 |
1977年 | 28篇 |
1976年 | 23篇 |
1975年 | 24篇 |
1974年 | 19篇 |
1973年 | 21篇 |
1972年 | 20篇 |
1970年 | 18篇 |
1969年 | 15篇 |
排序方式: 共有1903条查询结果,搜索用时 15 毫秒
1.
Summary— KR31080 (2-butyl-5-methyl-6-(1-oxopyridin-2-yl)-3-[[2'-(1H-tetrazol-5-yl) biphenyl-4-yl]methyl]-3H-imidazo[4,5-b] pyridine) is a potent inhibitor of angiotensin type 1 (AT1 ) receptors in rabbit aorta and human recombinant AT1 receptors. In the isolated rabbit thoracic aorta, KR31080 caused a nonparallel shift to the right of the concentration-response curves to angiotensin II (All) with decreased maximal response (pD'2 = 10.1 ± 0.1), but had no effect on the contractile response induced by norepinephrine. KR31080 inhibited specific [125 I]AII binding to rabbit aortic membranes (AT, receptors) and [125 I][Sar1 , Ile8 ]AII binding to human recombinant AT1 receptors in a concentration-dependent manner with IC50 values of 0.84 ± 0.08 nM and 1.92 ± 0.15 nM, respectively, but did not inhibit specific [125 I)AII binding to bovine cerebellum membranes (ÀT2 receptors). In the Scatchard analysis, KR31080 interacted with rabbit aortic AT1 receptors in a competitive manner, similar to losartan. These results demonstrate that KR31080 is a potent and AT1 selective angiotensin receptor antagonist which exerts a competitive antagonism in the [125 I]AII binding assay and insurmountable AT1 receptor antagonism in the functional study. 相似文献
2.
3.
Superficial bladder cancer: intravesical chemotherapy and tumour progression to muscle invasion or metastases 总被引:2,自引:0,他引:2
G Smith R A Elton G D Chisholm J E Newsam T B Hargreave 《British journal of urology》1986,58(6):659-663
Of 299 patients who presented with superficial bladder cancer (Ta, T1), 60 were treated by intravesical chemotherapy (Epodyl, methotrexate or mitomycin C). The rate of tumour progression to muscle invasion or metastases was identical for each intravesical regime. There was no evidence that mitomycin C promoted tumour progression. Carcinoma in situ in non-tumour-bearing urothelium was the most significant predictive factor for progression to muscle invasion or metastases. 相似文献
4.
I A Chisholm R F Braig 《Canadian journal of ophthalmology. Journal canadien d'ophtalmologie》1988,23(1):8-10
Area of visual field and colour discrimination were assessed in 167 eyes with ocular hypertension (from 100 women and 67 men with a mean age of 59.8 +/- 11.3 years). The patients were then followed for 3 years. During the follow-up period chronic open-angle glaucoma was diagnosed in 8 (8%) of the 100 eyes with a normal visual field and normal colour discrimination, 7 (14%) of the 50 eyes with a subnormal visual field or subnormal colour discrimination, and 17 (100%) of the 17 eyes with both a subnormal visual field and subnormal colour discrimination, a total of 32 eyes (19%). Our results suggest that chronic open-angle glaucoma develops early in ocular hypertensive eyes in which both the visual field and colour discrimination are subnormal. Glaucoma may not develop at all in eyes with normal values. 相似文献
5.
6.
Ian A. Chisholm Stephen M. Drance Teresa To 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》1989,227(2):110-113
Visual-field areas to a I2e stimulus were measured planimetrically using an X-Y digitizer and a computer program. Sampling of normal subjects and patients suspected of having glaucoma was done at two points in time. Calculations of eye-wall stress were done using ultrasonic data and intra-ocular pressure (IOP) measurements from patient records. For those suspected of having glaucoma who developed chronic open-angle glaucoma (COAG), the time of transition was the second point in time. The visual field area was regressed against patient age at the two points in time. No difference in the regression slopes was found for the normal subjects and unchanged patients. The patients who did develop glaucoma were significantly different. The mean annual rate of visual-field change (rate of decay) was calculated and found to be 28.5 mm2/year for the normals, 153.5 mm2/year for the suspects, and 376.4 mm2/year for those patients who developed glaucoma. The rate of visual-field decay only correlated with patient age (P = 0.03) and eye-wall stress (P < 0.01) in the patients who developed glaucoma. 相似文献
7.
A Notghi J L Anderton G D Chisholm D Hamer-Hodges S Wilkinson G Smith N T Galloway P L Yap R J Winney 《Scottish medical journal》1986,31(2):94-98
The effects of introduction of a low steroid regime and pre-transplant blood transfusion were evaluated. The kidney and patient survival rates for the period before such a policy was adopted were compared with the period after this policy. There has been a highly significant rise in patient survival rates to the present level of 95 per cent at three years. There was a similar rise in three year graft survival rates from less than 40 per cent to 66 per cent. 相似文献
8.
A D Kriketos D G Carey A B Jenkins D J Chisholm S M Furler L V Campbell 《Diabetic medicine》2003,20(4):294-300
AIMS: To examine the relationships between body composition and changes in fasting glycaemia, and in indices of insulin secretion and insulin action over 6 years in females with a family history of Type 2 diabetes with or without prior gestational diabetes ('at risk' group, AR) and control females (control group, C). METHODS: At baseline and at follow-up, an oral glucose tolerance test and dual energy X-ray absorptiometry assessment of body composition were performed. Indices of insulin resistance (HOMA R') and insulin secretion (HOMA beta') were obtained from fasting insulin and glucose concentrations. RESULTS: At baseline, the groups were similar for age, body mass index, fasting levels of plasma glucose and insulin, HOMA R' and HOMA beta'. Despite similar total body fatness, AR had significantly greater waist circumference and central fat (both P < 0.02) compared with C. At follow-up there was a significant increase in central adiposity only in AR, and the fasting plasma glucose (FPG) level was higher in AR compared with C (5.0 +/- 0.2 vs. 4.3 +/- 0.2 mmol/l, P = 0.02). This rise in plasma glucose in AR was related to a decline in HOMA beta' (r = 0.45, P = 0.0065). Both the baseline and the increments in total and central abdominal fat mass were associated with the time-related decline in HOMA beta'. CONCLUSIONS: Six years after initial assessment, AR showed deterioration in FPG levels due predominantly to a decline in insulin secretion index without major change in insulin resistance index. Importantly, baseline body fatness (especially central adiposity), as well as increases in fatness with time, were the major predictors of the subsequent decline of insulin secretion index and the consequent rise in FPG. 相似文献
9.
10.