全文获取类型
收费全文 | 14731篇 |
免费 | 779篇 |
国内免费 | 67篇 |
专业分类
耳鼻咽喉 | 237篇 |
儿科学 | 295篇 |
妇产科学 | 274篇 |
基础医学 | 2749篇 |
口腔科学 | 193篇 |
临床医学 | 1142篇 |
内科学 | 2623篇 |
皮肤病学 | 293篇 |
神经病学 | 1583篇 |
特种医学 | 941篇 |
外科学 | 2197篇 |
综合类 | 67篇 |
一般理论 | 4篇 |
预防医学 | 509篇 |
眼科学 | 448篇 |
药学 | 942篇 |
中国医学 | 25篇 |
肿瘤学 | 1055篇 |
出版年
2023年 | 69篇 |
2022年 | 117篇 |
2021年 | 236篇 |
2020年 | 175篇 |
2019年 | 205篇 |
2018年 | 247篇 |
2017年 | 209篇 |
2016年 | 287篇 |
2015年 | 351篇 |
2014年 | 435篇 |
2013年 | 605篇 |
2012年 | 819篇 |
2011年 | 835篇 |
2010年 | 537篇 |
2009年 | 478篇 |
2008年 | 758篇 |
2007年 | 788篇 |
2006年 | 782篇 |
2005年 | 815篇 |
2004年 | 730篇 |
2003年 | 672篇 |
2002年 | 628篇 |
2001年 | 226篇 |
2000年 | 213篇 |
1999年 | 179篇 |
1998年 | 166篇 |
1997年 | 104篇 |
1996年 | 104篇 |
1995年 | 96篇 |
1994年 | 92篇 |
1993年 | 72篇 |
1992年 | 114篇 |
1991年 | 123篇 |
1990年 | 100篇 |
1989年 | 83篇 |
1988年 | 60篇 |
1987年 | 68篇 |
1986年 | 71篇 |
1985年 | 64篇 |
1983年 | 64篇 |
1982年 | 67篇 |
1978年 | 61篇 |
1973年 | 68篇 |
1933年 | 69篇 |
1932年 | 62篇 |
1931年 | 58篇 |
1930年 | 76篇 |
1928年 | 60篇 |
1925年 | 65篇 |
1924年 | 60篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
2.
Anders Elm Pedersen Esben Gjerløff Wedebye Schmidt Jesper Freddie Sørensen Carsten Faber Boye Schnack Nielsen Kim Holmstrøm Silje Haukali Omland Peter Tougaard Søren Skov Bo Bang 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2015,123(7):547-555
TL1A is a TNF‐like cytokine which has been shown to co‐stimulate TH1 and TH17 responses during chronic inflammation. The expression of this novel cytokine has been investigated in inflammatory disorders like rheumatoid arthritis and inflammatory bowel disease, but little is known about expression and induction in psoriasis. Indeed, the pathogenesis in psoriasis is still not fully understood and it is speculated that cytokines other than TNF‐α are important in subsets of patients. Also, for patients with severe disease that are treated with systemic anti‐TNF‐α blockade, novel candidates to be used as disease and response biomarkers are of high interest. Here, we demonstrate TL1A expression in biopsies from psoriatic lesions. Also, we investigated spontaneous and induced TL1A secretion from PBMCs and blood levels from a cohort of psoriasis patients. Here, increased spontaneous secretion from PBMCs was observed as compared to healthy controls and a small subset of patients had highly elevated TL1A in the blood. Interestingly, activation of PBMCs with various cytokines showed a decreased sensitivity for TL1A activation in psoriasis patients compared to healthy controls.TL1A levels in blood and biopsies could not be correlated with disease activity with this patient cohort. Thus, additional large‐scale studies are warranted to investigate TL1A as a biomarker. 相似文献
3.
4.
5.
Marieke C Wichers Gunter Kenis Carsten Leue Ger Koek Geert Robaeys Michael Maes 《Neuropsychopharmacology》2006,60(1):77-79
BACKGROUND: Major depression has been associated cross-sectionally with increased cell-mediated immune activation but causality has been difficult to establish. This study prospectively investigated the hypothesis that baseline level of immune activation predicts the development of depression during interferon-alpha (IFN-alpha) treatment. METHODS: Sixteen hepatitis C patients without psychiatric disorder underwent IFN-alpha treatment. Proinflammatory and anti-inflammatory cytokines were determined before starting treatment. Presence of a major depressive disorder (MDD) was assessed at baseline and several times during treatment. RESULTS: Baseline soluble interleukin-2 receptor (sIL-2r), interleukin-6 (IL-6), and interleukin-10 (IL-10) concentrations were significantly increased in the five subjects that developed MDD during treatment compared with those that did not, with standardized effect sizes of 1.08, 1.16, and 1.25, respectively, controlling for marijuana use, cigarette smoking, and baseline level of depressive symptoms. CONCLUSIONS: Results suggest that increased immune activation, rather than an epiphenomenon, is a causal risk factor for the development of MDD. 相似文献
6.
Double-blind, placebo-controlled comparison of clonazepam and alprazolam for panic disorder 总被引:1,自引:0,他引:1
G E Tesar J F Rosenbaum M H Pollack M W Otto G S Sachs J B Herman L S Cohen S A Spier 《The Journal of clinical psychiatry》1991,52(2):69-76
To test the reported antipanic efficacy of clonazepam, the authors randomized 72 subjects with panic disorder to 6 weeks of treatment with either alprazolam, clonazepam, or placebo. Endpoint analysis demonstrated a significant beneficial effect of both active treatments, but not placebo treatment, on the frequency of panic attacks, overall phobia ratings, and the extent of disability. Comparison of the two active treatments revealed no significant differences and no consistent tendency for one agent to be favored over another, although power to detect small differences was limited. Sedation and ataxia were the most common side effects reported, but these effects were mild and transient and did not interfere with treatment outcome. The results of this double-blind, placebo-controlled trial are consistent with previous reports of clonazepam's antipanic efficacy. 相似文献
7.
Lindemann-Sperfeld Lutz Marintschev Ivan Zeugner Andreas Otto Wieland 《Trauma und Berufskrankheit》2002,4(1):S87-S90
Trauma und Berufskrankheit - Zusammenfassung Der Processus coronoideus ist der wichtigste knöcherne Stabilisator des Ellbogengelenks, der vordere Anteil des Lig. collaterale ulnae, welcher am... 相似文献
8.
9.
Julli?tte E M van Eerd Huub J J M Rennen Wim J G Oyen Thomas D Harris D Scott Edwards Frans H M Corstens Otto C Boerman 《Journal of nuclear medicine》2004,45(10):1747-1753
Radiolabeled chemotactic peptides have been studied for their applicability to the visualization of infectious and inflammatory foci. Because a radiolabeled leukotriene B4 (LTB4) antagonist allowed visualization of intramuscular E. coli abscesses in rabbits within a few hours after injection, we decided to test the imaging characteristics of this agent in a more clinically relevant model of pulmonary aspergillosis. The pharmacokinetics and imaging characteristics of the 111In-labeled LTB4 antagonist DPC11870 were studied in New Zealand White rabbits with experimental pulmonary aspergillosis infection. The imaging characteristics of 111In-DPC11870 were compared with those of 67Ga-citrate, a radiopharmaceutical commonly used to detect pulmonary infections in patients. METHODS: Pulmonary aspergillosis was induced in the left lung of rabbits by intratracheal inoculation of 1 x 10(8) conidia of Aspergillus fumigatus. Three days after the inoculation, the rabbits received 111In-DPC11870 or 67Ga-citrate intravenously. Images were acquired at several time points up to 24 h after injection. RESULTS: Pulmonary aspergillosis was visualized with both agents. Images acquired after injection of 111In-DPC11870 showed uptake in the pulmonary lesions from 6 h after injection. Because of accumulation at the site of infection and clearance from the background, the images improved with time. Region-of-interest analysis at 24 h after injection revealed infected lung-to-normal lung ratios of 5.0 +/- 1.5 for 111In-DPC11870 and 2.9 +/- 0.6 for 67Ga-citrate. CONCLUSION: The radiolabeled LTB4 antagonist DPC11870 clearly delineated experimentally induced pulmonary aspergillosis in rabbits. Images acquired at 24 h after injection of 111In-DPC11870 were superior to those obtained after injection of 67Ga-citrate. 相似文献
10.