全文获取类型
收费全文 | 2084篇 |
免费 | 134篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 54篇 |
儿科学 | 25篇 |
妇产科学 | 53篇 |
基础医学 | 256篇 |
口腔科学 | 24篇 |
临床医学 | 224篇 |
内科学 | 424篇 |
皮肤病学 | 10篇 |
神经病学 | 138篇 |
特种医学 | 34篇 |
外科学 | 286篇 |
综合类 | 20篇 |
预防医学 | 236篇 |
眼科学 | 136篇 |
药学 | 216篇 |
中国医学 | 3篇 |
肿瘤学 | 87篇 |
出版年
2022年 | 18篇 |
2021年 | 54篇 |
2020年 | 18篇 |
2019年 | 44篇 |
2018年 | 45篇 |
2017年 | 29篇 |
2016年 | 47篇 |
2015年 | 36篇 |
2014年 | 61篇 |
2013年 | 106篇 |
2012年 | 100篇 |
2011年 | 131篇 |
2010年 | 67篇 |
2009年 | 73篇 |
2008年 | 108篇 |
2007年 | 127篇 |
2006年 | 119篇 |
2005年 | 119篇 |
2004年 | 101篇 |
2003年 | 117篇 |
2002年 | 105篇 |
2001年 | 22篇 |
2000年 | 20篇 |
1999年 | 22篇 |
1998年 | 19篇 |
1997年 | 34篇 |
1996年 | 27篇 |
1995年 | 18篇 |
1994年 | 23篇 |
1993年 | 21篇 |
1992年 | 15篇 |
1991年 | 13篇 |
1990年 | 16篇 |
1989年 | 14篇 |
1988年 | 10篇 |
1987年 | 13篇 |
1986年 | 18篇 |
1985年 | 10篇 |
1984年 | 21篇 |
1983年 | 10篇 |
1982年 | 14篇 |
1981年 | 20篇 |
1980年 | 20篇 |
1979年 | 15篇 |
1978年 | 14篇 |
1977年 | 15篇 |
1976年 | 13篇 |
1975年 | 28篇 |
1972年 | 9篇 |
1968年 | 9篇 |
排序方式: 共有2226条查询结果,搜索用时 15 毫秒
1.
2.
3.
Dr. D. Byron May Pharm.D.M Dr. Richard H. Drew M.S. Dr. Kimberly C. Yedinak Pharm.D. Dr. John A. Bartlett M.D. 《Pharmacotherapy》1994,14(5):509-513
Study Objective . To investigate the effect of simultaneously administered didanosine (ddI) on the absorption of a single dose of itraconazole. Design . Randomized, crossover, unblinded single-dose pharmacokinetic study in healthy volunteers. Comparisons of itraconazole alone and itraconazole with simultaneous ddI were performed on days 1 and 15. Setting . A university medical center. Patients . Seven healthy men and women. Six subjects (86%) completed the study; one was removed due to the development of a rash. Interventions . Volunteers received a single 200-mg oral dose of itraconazole or itraconazole with concomitant oral ddI 300 mg (two 150-mg tablets) dispersed in 240 ml water. Each regimen was separated by a 2-week washout period. Serum samples were obtained frequently for 12 hours after the dose. Measurements and Main Results . Concentrations of itraconazole were determined using a microbiologic assay. Individual concentrations in serum versus time data were evaluated by linear regression analysis. Peak serum concentration and time to peak were determined by visual inspection of each individual's serum concentration-time curve. A mean ± SD peak serum itraconazole concentration of 0.90 ± 0.30 μg/ml was observed at 3.0 ± 0.7 hours when itraconazole was administered alone, compared with undetectable levels in all patients during therapy with ddI. Conclusions . Simultaneous oral administration of ddI significantly decreases absorption of itraconazole. These drugs should not be administered concurrently. 相似文献
4.
Babak Kasravi MD Cheryl L. Reid MD Byron J. Allen MD 《Journal of the American Society of Echocardiography》2004,17(12):599-1316
Coronary artery fistula is often considered to be a benign and rare congenital anomaly. It is usually an incidental finding encountered during routine cardiac catheterization. We report a case of a patient presenting with endocarditis involving a large coronary artery fistula connecting an aneurysmal circumflex coronary artery to the coronary sinus. The diagnosis was initially made by echocardiography and confirmed by cardiac catheterization. In addition, we briefly discuss the literature on management of this coronary anomaly. 相似文献
5.
6.
7.
Zhenfeng Xu Dajoie R Croslan Adalynn E Harris Gregory D Ford Byron D Ford 《Journal of cerebral blood flow and metabolism》2006,26(4):527-535
We have previously shown that neuregulin-1 (NRG-1) protects neurons from ischemic brain injury if administered before focal stroke. Here, we examined the therapeutic window and functional recovery after NRG-1 treatment in rats subjected to 90 mins of middle cerebral artery occlusion (MCAO) and 24 h of reperfusion. Neuregulin-1 (2.5 ng/kg bolus, 1.25 ng/kg/min infusion) reduced infarct volume by 89.2%+/-41.9% (mean+/-s.d.; n=8; P<0.01) if administered immediately after the onset of reperfusion. Neuroprotection was also evident if NRG-1 was administered 4 h (66.4%+/-52.6%; n=7; P<0.01) and 12 h (57.0%+/-20.8%; n=8; P<0.01) after reperfusion. Neuregulin-1 administration also resulted in a significant improvement of functional neurologic outcome compared with vehicle-treated animals (32.1%+/-5.7%; n=9; P<0.01). The neuroprotective effect of the single administration of NRG-1 was seen as long as 2 weeks after treatment. Neurons labeled with the neurodegeneration marker dye Fluoro-JadeB were observed after MCAO in the cortex, but the numbers were significantly reduced after NRG-1 treatment. These results indicate that NRG-1 is a potent neuroprotective compound with an extended therapeutic window that has practical therapeutic potential in treating individuals after ischemic brain injury. 相似文献
8.
9.
10.
Christopher A. Mills Joan W. Flacke Werner E. Flacke Byron C. Bloor Marvin D. Liu 《Journal canadien d'anesthésie》1990,37(2):238-244
Reversal of opioid effects by naloxone (NX) can lead to significant cardiovascular problems. We have reported previously that hypercapnic dogs develop greater increases in blood pressure and plasma catecholamine (CA) levels than hypocapnic ones when reversed with naloxone. We have also demonstrated differences between NX and nalbuphine (NBPH) in producing excitatory adrenergic responses when administered during normocapnia. The present study was designed to investigate possible dissimilarities in cardiovascular and sympathetic events after administration of either NX or NBPH in dogs made hypercapnic following fentanyl administration. After induction of anaesthesia with thiopentone and intubation, two groups of dogs were maintained with controlled ventilation on enflurane in oxygen anaesthesia and given 50 micrograms.kg-1 fentanyl IV. This caused a significant decrease in heart rate (HR) (P less than 0.001), mean arterial blood pressure (MAP) (P less than 0.001), and plasma concentrations of norepinephrine (NE) (P less than 0.002). Then, ventilation was decreased to produce a PaCO2 of 60 mmHg; this was accompanied by a significant elevation in plasma level of both epinephrine (EPI) (P less than 0.02) and NE (P less than 0.001). Administration of 20 micrograms.kg-1 NX to six dogs resulted in immediate increases in HR (P less than 0.01) and MAP (P less than 0.01), and a further rise in CA levels to greater than pre-fentanyl baseline values. In six other dogs, NBPH (0.3 mg.kg-1) caused increases in HR (P less than 0.001) and MAP (P less than 0.001) only, and the MAP rise was significantly less than that seen in the NX group (P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献