Treatment of patients with injuries of the ligaments of the knee joint]

178 patients with various ligamental injuries were treated according to the technique elaborated at the Institute. To restore ligaments preserved tendon homografts from the long fibular tendon with a remained terminal bone fragment were employed. The techniques of Gay-Growth-Smith and Sitenko underlie the methods of tendinoplasty applied. Following the operation therapeutic exercises, using water basin, massage, mechanotherapy and different kinds of physical therapy were employed differentially. Good results were obtained in a vast majority of patients (91.6%).     

Protection of the central nervous system from the action of perfringens and oedematiens in relation to the titer of antitoxin in the blood

Summary Experiments on passively and actively immunized rabbits with perfringens and oedematiens toxins showed that only the animals with a high blood antitoxin titer survive the introduction of lethal doses into the central nervous system.These investigations throw light on the conclusion, reached by certain clinicians on the basis of practical experlence in treating gas gangrene that large doses of serum produce better therapeutic results.Presented by Member of the Academy AMN USSR G. V. Vygodchikov     

Karyotype evolution and phylogenetic relationships of hamsters (Cricetidae, Muroidea, Rodentia) inferred from chromosomal painting and banding comparison

The evolutionary success of rodents of the superfamily Muroidea makes this taxon the most interesting for evolution studies, including study at the chromosomal level. Chromosome-specific painting probes from the Chinese hamster and the Syrian (golden) hamster were used to delimit homologous chromosomal segments among 15 hamster species from eight genera: Allocricetulus, Calomyscus, Cricetulus, Cricetus, Mesocricetus, Peromyscus, Phodopus and Tscherskia (Cricetidae, Muroidea, Rodentia). Based on results of chromosome painting and G-banding, comparative maps between 20 rodent species have been established. The integrated maps demonstrate a high level of karyotype conservation among species in the Cricetus group (Cricetus, Cricetulus, Allocricetulus) with Tscherskia as its sister group. Species within the genera Mesocricetus and Phodopus also show a high degree of chromosomal conservation. Our results substantiate many of the conclusions suggested by other data and strengthen the topology of the Muroidea phylogenetic tree through the inclusion of genome-wide chromosome rearrangements. The derivation of the muroids karyotypes from the putative ancestral state involved centric fusions, fissions, addition of heterochromatic arms and a great number of inversions. Our results provide further insights into the karyotype relationships of all species investigated.     

The correlation between plasma levels of oxytocin and betatrophin in non-diabetic and diabetic metabolic syndrome patients: A cross sectional study from Jordan

Background

Oxytocin (OXT) is a neurohypophyseal hormone that has been recently shown to possess a number of beneficial effects in diabetes and obesity. Betatrophin is a protein expressed in fat and liver that regulates lipid metabolism and promotes pancreatic β-cell proliferation. It is not investigated yet whether OXT and betatrophin levels correlate in metabolic syndrome (MS) or diabetes patients.

Effect of metformin combined with lifestyle modification versus lifestyle modification alone on proinflammatory-oxidative status in drug-naïve pre-diabetic and diabetic patients: A randomized controlled study

Background

Targeting biomarkers of oxidative-proinflammatory stress may result in improvement of modifiable metabolic syndrome, pre-diabetes and diabetes risk factors and subsequent risk reduction.