全文获取类型
收费全文 | 2139篇 |
免费 | 157篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 97篇 |
妇产科学 | 12篇 |
基础医学 | 261篇 |
口腔科学 | 35篇 |
临床医学 | 237篇 |
内科学 | 437篇 |
皮肤病学 | 15篇 |
神经病学 | 207篇 |
特种医学 | 78篇 |
外科学 | 150篇 |
综合类 | 13篇 |
一般理论 | 2篇 |
预防医学 | 407篇 |
眼科学 | 23篇 |
药学 | 238篇 |
中国医学 | 2篇 |
肿瘤学 | 86篇 |
出版年
2023年 | 8篇 |
2022年 | 22篇 |
2021年 | 46篇 |
2020年 | 26篇 |
2019年 | 37篇 |
2018年 | 64篇 |
2017年 | 41篇 |
2016年 | 38篇 |
2015年 | 51篇 |
2014年 | 72篇 |
2013年 | 89篇 |
2012年 | 137篇 |
2011年 | 105篇 |
2010年 | 87篇 |
2009年 | 88篇 |
2008年 | 91篇 |
2007年 | 129篇 |
2006年 | 122篇 |
2005年 | 96篇 |
2004年 | 90篇 |
2003年 | 51篇 |
2002年 | 75篇 |
2001年 | 63篇 |
2000年 | 83篇 |
1999年 | 64篇 |
1998年 | 59篇 |
1997年 | 46篇 |
1996年 | 31篇 |
1995年 | 30篇 |
1994年 | 30篇 |
1993年 | 17篇 |
1992年 | 34篇 |
1991年 | 45篇 |
1990年 | 27篇 |
1989年 | 29篇 |
1988年 | 30篇 |
1987年 | 24篇 |
1986年 | 22篇 |
1985年 | 24篇 |
1984年 | 18篇 |
1983年 | 7篇 |
1982年 | 12篇 |
1981年 | 6篇 |
1980年 | 4篇 |
1979年 | 6篇 |
1978年 | 4篇 |
1976年 | 4篇 |
1974年 | 3篇 |
1972年 | 3篇 |
1970年 | 3篇 |
排序方式: 共有2314条查询结果,搜索用时 31 毫秒
1.
SH Lee† CP Choi‡ HC Eun† OS Kwon† 《Journal of the European Academy of Dermatology and Venereology》2006,20(7):860-863
BACKGROUND: On December 26, 2004, the biggest earthquake for 40 years, measuring 9.0 on the Richter scale, triggered a tsunami that pounded the coastal areas of South Asia and East Africa. The effects of the tsunami on skin conditions have not been evaluated. OBJECTIVE: To determine the influence of the tsunami on skin conditions by evaluating the skin problems of patients presenting at hospitals after the tsunami. METHODS: Between 5 and 25 January 2005, two dermatologists evaluated patients who complained of skin problems at an outpatient clinic and emergency room of a general hospital in Banda Aceh, Aceh Province, Indonesia. RESULTS: The total number of patients that presented during the study period was 235 (131 males and 104 females), and they had a total of 265 skin problems. In terms of age distribution, most subjects were in their fourth decade (23.0%), followed by the third (22.6%) and fifth decade (16.6%). The most prevalent skin problems were infections-infestations (32.5%), followed by eczemas (29.8%) and traumatic skin disorders (29.4%). In males, traumatic skin disorders were most common. The great majority of infection-infestation cases involved superficial fungal infections. Contact dermatitis accounted for three-quarters of eczema cases, and mainly involved the arms (40.0%) and legs (27.1%). The majority of traumatic skin disorders were lacerations, punctures and penetrations, and the feet (44.7%) and hands (18.8%) were most frequently affected. CONCLUSIONS: Unhygienic conditions, exposure to a hazardous environment and contact with various objects during and after the tsunami probably increased the prevalence of infections-infestations, traumatic skin disorders and contact dermatitis. To prevent these problems and associated secondary bacterial infections, health-related education and early medical management are required. 相似文献
2.
3.
Anthony M Dart Jan Erik Otterstad Bridget-Anne Kirwan John D Parker Sophie de Brouwer Philip A Poole-Wilson Jacobus Lubsen 《European journal of echocardiography》2007,8(4):275-283
AIMS: To evaluate the relationship between echocardiographic cardiac function and outcome in patients with stable symptomatic angina. METHODS: Baseline echo left ventricular ejection fraction and volume data measured in a central laboratory was available for 7016 patients (92% of the total) participating in the ACTION trial (A Coronary disease Trial Investigating Outcome with Nifedipine GITS). Ejection fraction was also measured by investigators. Evaluation of the different echocardiographic variables was based on adjusted hazard ratios comparing the unfavourable limit of the 90% range of the variable concerned to the favourable limit. RESULTS: The centrally measured ejection fraction was the most powerful predictor of all-cause death (adjusted hazard ratio=2.5), myocardial infarction, any stroke or transient ischaemic attack and overt heart failure (adjusted hazard ratio=4.5). The addition of either end systolic volume or end diastolic volume to ejection fraction did not materially affect the power of prediction. Compared to the central ejection fraction measurement, the investigator-measured ejection fraction was a less powerful predictor for all outcomes considered. CONCLUSION: Routine echocardiography carefully analysed by standardised methods provides useful prognostic information in patients with stable angina, including for total mortality. 相似文献
4.
5.
6.
Brenda D. Jamerson Pharm.D. George E. Dukes Pharm.D. Kim L.R. Brouwer Pharm.D. Ph.D. Karl H. Dorm Ph.D. John A. Messenheimer M.D. J. Robert Powell Pharm.D. 《Pharmacotherapy》1994,14(1):47-52
Study Objective . To compare the frequency, severity, and time course of venous irritation after administration of a single intravenous dose of phenytoin with an equimolar dose of fosphenytoin, a water-soluble phenytoin prodrug. Design . Randomized, double-blind, two-period, crossover study. Setting . University hospital clinical research unit. Patients . Twelve healthy volunteers within 15% of ideal body weight and with no clinically significant abnormalities on physical examination, medical history, or laboratory assessment. Interventions . Volunteers randomly received a 30-minute infusion of phenytoin sodium 250 mg (250 mg/5 ml) or an equimolar dose of fosphenytoin 375 mg (375 mg/5 ml). Subjects returned for the crossover treatment 14–21 days later. Measurements and Main Results . Subjects assessed venous irritation (pain, burning, itching), and investigators evaluated phlebitis (erythema, swelling, tenderness), induration, exudation, and cording. Phenytoin was associated with a significantly higher degree of pain at the infusion site in all subjects and a significant degree of phlebitis in eight subjects (p<0.05); cording occurred in six subjects. The time course of phenytoin-induced phlebitis was bimodal. Erythema and tenderness were prominent at the end of the infusion and again at 24 hours. Cording was first noted between 24 hours and 1 week after infusion. In contrast, fosphenytoin was associated with mild pain in two subjects, one incident of phlebitis, and no erythema or cording. Conclusions . Fosphenytoin administration resulted in significantly less venous irritation and phlebitis compared with an equimolar dose of phenytoin. The clinical use of this water-soluble phenytoin prodrug should minimize the frequency and severity of infusion-site reactions and should allow convenient, rapid, intravenous administration of drug, undiluted or admixed with intravenous solutions. 相似文献
7.
8.
9.
10.
Nuclear magnetic resonance relaxation in experimental brain edema: effects of water concentration, protein concentration, and temperature 总被引:2,自引:0,他引:2
Proton relaxation times T1 and T2 of macromolecular solutions, bovine brain tissues, and experimental cat brain edema tissues were studied as a function of water concentration, protein concentration, and temperature. A linear relation was found between the inverse of the weight fraction of tissue water and the spin-lattice relaxation rate, R1, based on a fast proton exchange model for relaxation. This correlation was also found for the spin-spin relaxation rate, R2, of gray matter samples and macromolecular solutions at low concentrations. Concentrated solutions of protein-water samples showed an enhanced relaxation due to viscosity effects. The T2 of white matter was considerably lengthened with elevated water concentration, but showed no straightforward relation with the total tissue water content. The relaxation times of all samples increased with temperature, supporting the assumption of fast proton exchange in the model for relaxation. This was not found for white matter, in which T2 decreased with increasing temperature, which indicated that intermediate or even slow exchange was present. The relation found between relaxation times and tissue water content can be used to predict the amount of and/or increase in tissue water due to water-elevating processes such as edema. 相似文献