全文获取类型
收费全文 | 845篇 |
免费 | 85篇 |
国内免费 | 7篇 |
专业分类
儿科学 | 71篇 |
妇产科学 | 39篇 |
基础医学 | 91篇 |
口腔科学 | 30篇 |
临床医学 | 95篇 |
内科学 | 126篇 |
皮肤病学 | 6篇 |
神经病学 | 106篇 |
特种医学 | 65篇 |
外科学 | 71篇 |
综合类 | 19篇 |
一般理论 | 1篇 |
预防医学 | 45篇 |
眼科学 | 69篇 |
药学 | 52篇 |
中国医学 | 3篇 |
肿瘤学 | 48篇 |
出版年
2022年 | 5篇 |
2021年 | 10篇 |
2020年 | 7篇 |
2019年 | 12篇 |
2018年 | 18篇 |
2017年 | 22篇 |
2016年 | 14篇 |
2015年 | 29篇 |
2014年 | 33篇 |
2013年 | 37篇 |
2012年 | 26篇 |
2011年 | 36篇 |
2010年 | 22篇 |
2009年 | 26篇 |
2008年 | 32篇 |
2007年 | 23篇 |
2006年 | 25篇 |
2005年 | 21篇 |
2004年 | 19篇 |
2003年 | 24篇 |
2002年 | 22篇 |
2001年 | 30篇 |
2000年 | 17篇 |
1999年 | 19篇 |
1998年 | 27篇 |
1997年 | 30篇 |
1996年 | 34篇 |
1995年 | 18篇 |
1994年 | 26篇 |
1993年 | 17篇 |
1992年 | 28篇 |
1991年 | 17篇 |
1990年 | 17篇 |
1989年 | 23篇 |
1988年 | 19篇 |
1987年 | 18篇 |
1986年 | 17篇 |
1985年 | 25篇 |
1984年 | 7篇 |
1983年 | 11篇 |
1982年 | 9篇 |
1981年 | 3篇 |
1980年 | 12篇 |
1979年 | 5篇 |
1977年 | 4篇 |
1976年 | 8篇 |
1974年 | 7篇 |
1973年 | 3篇 |
1968年 | 3篇 |
1967年 | 3篇 |
排序方式: 共有937条查询结果,搜索用时 15 毫秒
1.
2.
3.
Benign intracranial hypertension and recombinant growth hormone therapy in Australia and New Zealand
PA Crock JD McKenzie AM Nicoll NJ Howard W Cutfield LK Shield G Byrne 《Acta paediatrica (Oslo, Norway : 1992)》1998,87(4):381-386
Benign intracranial hypertension (BIH) is reported in three children from Australia and one from New Zealand, who were being treated with recombinant human growth hormone (rhGH). Three males and one female, aged between 10.5 and 14.2 y, developed intracranial hypertension within 2 weeks to 3 months of starting treatment. A national database, OZGROW, has been prospectively collecting data on all 3332 children treated with rhGH in Australia and New Zealand from January 1986 to 1996. The incidence of BIH in children treated with growth hormone (GH) is small, 1.2 per 1000 cases overall, but appears to be greater with biochemical GHD (<10IUml -1 ), i.e. 6.5/1000 (3 in 465 cases), relative risk 18.4, 95% confidence interval 1.9-176.1, than in all other children on the database. The incidence in patients with Turner's syndrome was 2.3/1000 (1 in 428 cases). No cases in patients with partial GHD (10–20 IUml -1 ) or chronic renal failure were identified. Possible causative mechanisms are discussed. The authors'practice is now to start GH replacement at less than the usual recommended dose of 14IUm-2 week-1 in those children considered to be at high risk of developing BIH. Ophthalmological evaluation is recommended for children before and during the first few months following commencement of rhGH therapy and is mandatory in the event of peripheral or facial oedema, persistent headaches, vomiting or visual symptoms. The absence of papilledema does not exclude the diagnosis. 相似文献
4.
Inverse changes in erythroid cell volume and number regulate the hematocrit in newborn genetically hypertensive rats.
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
J W Boylan J B Van Liew P U Feig 《Proceedings of the National Academy of Sciences of the United States of America》1991,88(21):9848-9852
Erythrocytosis and microcytosis have been described in strains of genetically hypertensive rats and in essentially hypertensive humans. Published discussion of these phenomena has centered around their relationship to observed alterations in ionic transport and the pathogenesis of hypertension. In presenting data for another strain of spontaneously hypertensive rats in which these findings are exhibited, we note that erythroid cell size decreases concurrently with the increase in cell numbers so that the hematocrit and the mean corpuscular hemoglobin concentration remain constant. Data from the literature support the hypothesis that erythroid cell size is inversely proportional to cell count in a large number of species. Erythrocytosis, as it develops in the neonatal rat, is a consequence of the marked immaturity of this species at birth. Erythrocytosis in the spontaneously hypertensive rat is not due to a difference in the affinity of its hemoglobin for oxygen or to significant tissue anorexia. Microcytosis in the spontaneously hypertensive rat is the consequence of a continuation of the linear volume decrease with age of its erythroid cells seen in the normotensive animals and may be accounted for by the production of smaller cells with concomitant regulation of individual cell volume. 相似文献
5.
B.E. Jones C.B. Boylan M. Fritsche M. Juhasz C. Jackson S.J. Wiegand C. Hyman R.M. Lindsay C.A. Altar 《Brain research》1996,709(2):275
Rat models of Parkinson's disease typically employ a rapid nigral injection of 6-hydroxydopamine (6-OHDA) to produce a near-complete loss of nigrostriatal dopamine neurons, and thus model end stage disease. The present report describes the use of a continuous, low dose infusion of 6-OHDA into the striatum which produces a terminal axotomy of nigrostriatal dopamine neurons and protracted behavioral response. A solution of 6-OHDA in 0.4% ascorbate, delivered at 37°C from osmotic minipumps, was stable for 8 days as determined by its retained toxicity to a dopaminergic neuroblastoma cell line. The continuous infusion of 0.2 μg 6-OHDA per h did not affect the striatal uptake of [3H]GABA, [3H]choline, or [3H]glutamate but reduced [3H]dopamine uptake by 55% within 1.5 days after the start of the infusion. The striatal infusion of 6-OHDA produced a dose-dependent reduction of striatal dopamine and DOPAC levels but did not alter HVA, 5-HT, or 5-HIAA. An increase in amphetamine-induced ipsiversive rotations occurred within 1.5 days after the acute striatal injection of 20 μg or 30 μg of 6-OHDA but required 4 days to develop with the continuous 6-OHDA infusion. The topography of the lesion mapped by [3H]mazindol binding showed that, begining by 1.5 days, a diffuse depletion of terminals encompassed much of the striatum in the 30 μg acute injection group, whereas in the continuously infused rats, the lesion was apparent only by 4 days and was restricted to a smaller and more completely lesioned area. Unlike acutely lesioned animals, continuously infused rats revealed no obvious loss of dopamine neurons in the pars compacta by 5 weeks after 6-OHDA. The continuous striatal infusion of 6-OHDA can produce a topographically limited terminal axotomy of dopamine neurons and a protracted behavioral impairment. 相似文献
6.
Warren Scherer D.D.S. Robert Boylan Ph.D. † Sona Bhatt B.S. ‡ 《Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]》1992,4(3):84-85
This in vitro study compared the antimicrobial effect of several at-home bleaching agents and an oral antiseptic against anaerobic bacteria that are commonly found in the oral cavity. Zones of inhibition produced by Rembrandt Lighten Bleaching Gel, Opalescence, and Peroxyl were measured and compared. All the materials produced zones of inhibition with the five bacteria used in the study. 相似文献
7.
The rotations and retractions of the eyeball due to co-contraction of the extraocular muscles are investigated using a model of the mechanics of the orbital plant. The hypothesis that the rotational movements are secondary to globe retraction is not supported. 相似文献
8.
9.
10.