全文获取类型
收费全文 | 482篇 |
免费 | 50篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 22篇 |
基础医学 | 178篇 |
临床医学 | 108篇 |
内科学 | 97篇 |
皮肤病学 | 1篇 |
神经病学 | 10篇 |
特种医学 | 3篇 |
外科学 | 25篇 |
预防医学 | 49篇 |
眼科学 | 1篇 |
药学 | 28篇 |
肿瘤学 | 9篇 |
出版年
2022年 | 5篇 |
2021年 | 10篇 |
2020年 | 7篇 |
2019年 | 7篇 |
2018年 | 10篇 |
2017年 | 7篇 |
2016年 | 10篇 |
2015年 | 18篇 |
2014年 | 22篇 |
2013年 | 23篇 |
2012年 | 35篇 |
2011年 | 28篇 |
2010年 | 16篇 |
2009年 | 14篇 |
2008年 | 26篇 |
2007年 | 35篇 |
2006年 | 23篇 |
2005年 | 25篇 |
2004年 | 23篇 |
2003年 | 26篇 |
2002年 | 20篇 |
2001年 | 28篇 |
2000年 | 20篇 |
1999年 | 22篇 |
1998年 | 7篇 |
1997年 | 5篇 |
1996年 | 4篇 |
1995年 | 4篇 |
1994年 | 3篇 |
1993年 | 2篇 |
1992年 | 9篇 |
1991年 | 5篇 |
1990年 | 5篇 |
1989年 | 2篇 |
1988年 | 3篇 |
1987年 | 5篇 |
1986年 | 1篇 |
1985年 | 6篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1982年 | 1篇 |
1978年 | 3篇 |
1977年 | 2篇 |
排序方式: 共有532条查询结果,搜索用时 15 毫秒
1.
M P Plá J Berenguer J A Arzuaga R Ba?ares J R Polo E Bouza 《Diagnostic microbiology and infectious disease》1992,15(8):703-706
Cutaneous aspergillosis is generally associated with immunosuppression, burns, and major trauma. Most cases are acquired by direct inoculation, although cutaneous involvement does occasionally occur with disseminated disease. Surgical wound infections caused by Aspergillus species are very unusual and to our knowledge have not been described in the setting of organ transplantation. We describe two liver transplant recipients who developed wound aspergillosis during a nosocomial outbreak of Aspergillus infection. Infection developed in the second and fourth postoperative week respectively, and in both cases wound appearance mimicked necrotizing fasciitis. Both patients died despite local debridement and antifungal therapy with amphotericin B. Aspergillus must be added to the list of potential pathogens of surgical wounds, especially in the setting of organ transplantation. 相似文献
2.
The prognostic significance of acute renal failure after renal transplantation in patients treated with cyclosporin 总被引:2,自引:0,他引:2
Perez Fontan M; Rodriguez-Carmona A; Bouza P; Valdes F 《QJM : monthly journal of the Association of Physicians》1998,91(1):27-40
We studied 733 cadaveric renal transplant patients (747 transplants) under
cyclosporin immunosuppression, to: (i) establish the risk profile for acute
renal failure (ARF) after renal transplantation in a unit using many
sub-optimal donors; (ii) assess the long-term prognostic relevance of ARF;
and (iii) explore the synergistic prognostic significance of delayed graft
function and acute rejection during the early post-transplant period.
Transplanting from a non-heart-beating or elderly donor, protracted cold
ischaemia, haemodialysis immediately before transplant surgery, poor HLA
matching, and grafting to a hypersensitized recipient without residual
renal function, all independently predicted delayed graft function. This
delay had no detrimental effect on patient or graft survival, but prolonged
ARF was associated with increased mortality from infection. Late markers of
graft dysfunction (poor graft function, proteinuria, hypertension) were
highly prevalent among grafts affected by ARF, specially in prolonged ARF.
Delayed graft function and early acute rejection showed a definite, albeit
not strong, additive impact on late graft survival, and also on the
prevalence of late markers of graft dysfunction.
相似文献
3.
4.
Comparison of Broth Microdilution Method Using Haemophilus Test Medium and Agar Dilution Method for Susceptibility Testing of Eikenella corrodens 下载免费PDF全文
Luis Alcal Fernando García-Garrote Emilia Cercenado Teresa Pelez Gema Ramos Emilio Bouza 《Journal of clinical microbiology》1998,36(8):2386-2388
Susceptibility testing of Eikenella corrodens is usually performed by a Mueller-Hinton sheep blood agar dilution (AD) method. However, this method is impractical for testing only a few strains. We compared AD with the broth microdilution method using Haemophilus test medium (HTM) in order to determine the susceptibility of 36 clinical isolates of E. corrodens to eight antimicrobial agents. MICs obtained by the HTM method yielded 95.5 and 84% agreement (within 2 and 1 log2 dilutions, respectively) with those obtained by AD. The HTM method with incubation in CO2 for 48 h was highly reproducible and constitutes an easy alternative for antimicrobial susceptibility testing of E. corrodens. 相似文献
5.
E. Bouza C. Martín-Scapa J. C. L. Bernaldo de Quirós D. Martínez-Hernández J. Menarguez J. Gómez-Rodrigo J. Cosín M. J. Sagues-Cifuentes 《European journal of clinical microbiology & infectious diseases》1988,7(6):785-788
A total of 67 cases of tuberculosis was diagnosed in the first 100 cases of AIDS, diagnosed according to the former CDC criteria, at a hospital in Madrid, Spain. This is the highest known prevalence of tuberculosis in AIDS patients both within and outside Spain. The clinical manifestations of tuberculosis were very variable and atypical. The rate of isolation ofMycobacterium tuberculosis from blood was particularly high: of 25 patients in whom blood cultures were performed, 16 were positive. In a third of the patients with proven mycobacteremia, blood was the first or the only positive specimen. In general, therapy resulted in rapid clinical improvement, but in some cases mycobacteria were isolated from clinical or necroscopy specimens months after what was considered adequate therapy. 相似文献
6.
E. Bouza R. San Juan P. Muñoz J. Pascau A. Voss M. Desco 《Clinical microbiology and infection》2004,10(9):838-842
The laboratory workload, microbiological techniques and aetiology of catheter-related infections in European hospitals are mostly unknown. The present study (ESGNI-005) comprised a 1-day (22 October 2001), laboratory-based, point-prevalence survey based on a questionnaire completed by microbiology laboratories in European (European Union (EU) and non-EU) hospitals. Also included were questions requesting retrospective information for the year 2000. In total, 151 hospitals from 26 European countries participated, of which 78.1% were teaching institutions. Overall, the estimated population served by these institutions was 121,363,800, and the estimated number of admissions during 2000 was 6,712,050. The total number of catheter tips processed during 2000 was 142,727, or 21/1,000 admissions, of which 23.7% were considered to be positive in the institutions using semiquantitative or quantitative techniques. Overall, EU centres received significantly more catheter tip samples/1,000 admissions and had a significantly higher rate of 'positivity' (p < 0.0001) than non-EU centres. Of the institutions surveyed, 11.4% (7.2% in EU countries and 23.7% in non-EU countries; p 0.04) used only qualitative techniques for catheter tip sample processing. On the day of the study, 167 microorganisms were recovered from significant catheter tip cultures (122 patients), of which Gram-positive bacteria represented 70.7%, Gram-negative bacteria 22.2%, and yeasts 7.2%. The five most common microorganisms were coagulase-negative staphylococci, Staphylococcus aureus, Candida spp., Enterococcus spp. and Pseudomonas spp. Overall, 19% of catheter tip cultures were polymicrobial. In the case of S. aureus, 40% of isolates were resistant to oxacillin, as were 63.4% of coagulase-negative staphylococcus isolates. Of 37 Gram-negative isolates, 35% were resistant to cefotaxime, 31% to ceftazidime, and 27% to ciprofloxacin. Imipenem and cefepime had the lowest reported rates of resistance (11%). 相似文献
7.
The group G streptococcus may be a more common human pathogen than previously recognized. A case of group G streptococcal endocarditis is reported and the 11 cases reported previously are reviewed. Group G endocarditis may have significant clinical and prognostic differences from endocarditis caused by the more commonly identified viridans or group D streptococci. Routine serologic grouping of beta-hemolytic streptococcal isolates from serious infections is warranted. 相似文献
8.
9.
10.
Jean-François Timsit Mark Rupp Emilio Bouza Vineet Chopra Tarja Kärpänen Kevin Laupland Thiago Lisboa Leonard Mermel Olivier Mimoz Jean-Jacques Parienti Garyphalia Poulakou Bertrand Souweine Walter Zingg 《Intensive care medicine》2018,44(6):742-759
Intravascular catheters are inserted into almost all critically ill patients. This review provides up-to-date insight into available knowledge on epidemiology and diagnosis of complications of central vein and arterial catheters in ICU. It discusses the optimal therapy of catheter-related infections and thrombosis. Prevention of complications is a multidisciplinary task that combines both improvement of the process of care and introduction of new technologies. We emphasize the main component of the prevention strategies that should be used in critical care and propose areas of future investigation in this field. 相似文献