全文获取类型
收费全文 | 1353篇 |
免费 | 96篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 43篇 |
妇产科学 | 14篇 |
基础医学 | 203篇 |
口腔科学 | 28篇 |
临床医学 | 183篇 |
内科学 | 222篇 |
皮肤病学 | 20篇 |
神经病学 | 161篇 |
特种医学 | 20篇 |
外科学 | 141篇 |
综合类 | 8篇 |
一般理论 | 4篇 |
预防医学 | 219篇 |
眼科学 | 14篇 |
药学 | 103篇 |
中国医学 | 1篇 |
肿瘤学 | 65篇 |
出版年
2024年 | 2篇 |
2023年 | 24篇 |
2022年 | 41篇 |
2021年 | 98篇 |
2020年 | 59篇 |
2019年 | 75篇 |
2018年 | 68篇 |
2017年 | 50篇 |
2016年 | 49篇 |
2015年 | 60篇 |
2014年 | 65篇 |
2013年 | 66篇 |
2012年 | 135篇 |
2011年 | 141篇 |
2010年 | 63篇 |
2009年 | 41篇 |
2008年 | 93篇 |
2007年 | 64篇 |
2006年 | 75篇 |
2005年 | 63篇 |
2004年 | 38篇 |
2003年 | 34篇 |
2002年 | 20篇 |
2001年 | 1篇 |
2000年 | 3篇 |
1999年 | 6篇 |
1998年 | 5篇 |
1997年 | 4篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1988年 | 2篇 |
1982年 | 1篇 |
1977年 | 1篇 |
排序方式: 共有1452条查询结果,搜索用时 328 毫秒
1.
2.
3.
4.
5.
Gordon ES Gordish-Dressman HA Devaney J Clarkson P Thompson P Gordon P Pescatello LS Hubal MJ Pistilli EE Gianetti G Kelsey B Hoffman EP 《European journal of human genetics : EJHG》2005,13(9):1047-1054
The purpose of this study was to assess the impact of genetic self-knowledge (nondisease genotype information) on individual self-concept and Health Orientation Scale (HOS). Adult volunteers (n=257) were recruited from an ongoing genetic association study identifying muscle quantitative trait loci (QTLs). Participants completed psychosocial assessments before and after 12 weeks of resistance training of the nondominant arm. At study exit, a genetic counselor informed participants of genetic test results on three to four genes that have an association with muscle-related traits, and counseled subjects on the potential significance of these findings. The second psychosocial assessment was performed immediately following this counseling session. The Tennessee Self-Concept Scale v.2 (TSCS:2) and the HOS showed female subjects to have a significantly greater positive change between first and second assessments, relative to male subjects. Most self-concept subscales improved significantly, when 'neutral' genotypes (no anticipated beneficial or deleterious impact) were reported, compared to positive genotypes. TSCS:2 subscales showing improvement included: total (P=0.013); physical (P=0.004); satisfaction (P=0.019); and behavioral (P=0.047). HOS subscales showing improvement included health image concern (P=0.006); and health expectations (P=0.047). In conclusion, these results suggest that genetic self-knowledge affects self-concept, consistent with the 'attribution' theory. Individuals who received neutral genetic information attributed positive changes from the exercise program to their own abilities, while those who received positive information were more likely to attribute positive changes to their genetics. This study is limited by the ability to determine the direction of the impact of nondisease genetic information presented to participants. 相似文献
6.
Use of in vivo-induced antigen technology for identification of Escherichia coli O157:H7 proteins expressed during human infection 下载免费PDF全文
John M Kudva IT Griffin RW Dodson AW McManus B Krastins B Sarracino D Progulske-Fox A Hillman JD Handfield M Tarr PI Calderwood SB 《Infection and immunity》2005,73(5):2665-2679
Using in vivo-induced antigen technology (IVIAT), a modified immunoscreening technique that circumvents the need for animal models, we directly identified immunogenic Escherichia coli O157:H7 (O157) proteins expressed either specifically during human infection but not during growth under standard laboratory conditions or at significantly higher levels in vivo than in vitro. IVIAT identified 223 O157 proteins expressed during human infection, several of which were unique to this study. These in vivo-induced (ivi) proteins, encoded by ivi genes, mapped to the backbone, O islands (OIs), and pO157. Lack of in vitro expression of O157-specific ivi proteins was confirmed by proteomic analysis of a mid-exponential-phase culture of E. coli O157 grown in LB broth. Because ivi proteins are expressed in response to specific cues during infection and might help pathogens adapt to and counter hostile in vivo environments, those identified in this study are potential targets for drug and vaccine development. Also, such proteins may be exploited as markers of O157 infection in stool specimens. 相似文献
7.
Prostaglandin E2 synthesis and suppression of fibroblast proliferation by alveolar epithelial cells is cyclooxygenase-2-dependent 总被引:5,自引:0,他引:5
Lama V Moore BB Christensen P Toews GB Peters-Golden M 《American journal of respiratory cell and molecular biology》2002,27(6):752-758
Alveolar epithelial cells (AECs) may influence neighboring fibroblasts by the elaboration of prostaglandin E(2) (PGE(2)). This prostanoid can be synthesized via "constitutive" cyclooxygenase (COX)-1 and "inducible" COX-2 enzyme isoforms. We compared AECs isolated from wild-type (WT), COX-1 knockout (KO), and COX-2 KO mice to determine the contribution of COX isoforms to AEC PGE(2) synthesis and capacity for suppression of fibroblast proliferation in co-cultures. WT AECs constitutively expressed both COX-1 and COX-2 isoforms by immunoblot analysis. COX-1 KO cells and WT cells comparably augmented PGE(2) synthesis following incubation with lipopolysaccharide or interleukin-1, whereas COX-2 KO cells were unable to do so. Surprisingly, however, constitutive generation of PGE(2) was also dramatically reduced only in COX-2 KO cells. When co-cultured with WT murine lung fibroblasts, AECs from WT and COX-1 KO animals suppressed serum-induced fibroblast proliferation, whereas COX-2-deficient AECs caused a modest enhancement in fibroblast proliferation. These results indicate that PGE(2) synthetic capacity in AECs is predominantly COX-2-dependent under both basal and stimulated conditions. They also demonstrate conclusively that AECs can modulate fibroblast function by the elaboration of suppressive prostanoids. These alterations in AEC phenotype likely contribute to the propensity for pulmonary fibrosis observed in COX-2-deficient mice. 相似文献
8.
Thomas M Morgan Lan Xiao Patrick Lyons Bethany Kassebaum Harlan M Krumholz John A Spertus 《BMC medical genetics》2008,9(1):66
Background
Many candidate genes have been reported to be risk factors for acute coronary syndrome (ACS), but their impact on clinical prognosis following ACS is unknown. 相似文献9.
Grad Roland Leger Daniel Kaczorowski Janusz Schuster Tibor Adler Samara Aman Marya Archibald Douglas Beaulieu Marie-Claude Chmelicek John Cornelissen Evelyn Delleman Bethany Hadj-Mimoune Sonia Horvey Samantha Macaluso Steven Mintsioulis Stephen Murdoch Stuart Ng Brian Papineau Alain Rangwala Sohil Rousseau Mathieu Rudkin Teresa Schabort Inge Schultz Karen Snow Pamela Wong Eric Wu Pearson Brailovsky Carlos 《Advances in health sciences education : theory and practice》2021,26(3):771-783
Advances in Health Sciences Education - Spaced education is a learning strategy to improve knowledge acquisition and retention. To date, no robust evidence exists to support the utility of spaced... 相似文献
10.
Bethany D. Williams Susan B. Sisson Irene O. Padasas Dipti A. Dev 《Journal of nutrition education and behavior》2021,53(4):299-308
ObjectiveTo determine differences by Child and Adult Care Food Program (CACFP) participation on nutrition requirements and best practices and barriers to implementing both in early care and education programs (ECEs) stratified by context (centers vs home-based ECEs).DesignCross-sectional survey.SettingThree-thousand and fourteen licensed Nebraska ECEs in 2017.ParticipantsOne-thousand three hundred forty-five ECEs.Main Outcome Measure(s)Director-reported nutrition practices in classrooms serving children aged 2-5 years (8 requirements for foods served, 5 best practices for foods served, and 14 best practices for mealtime behaviors).AnalysisChi-square analysis adjusted for multiple comparisons.ResultsOf the sample, 86.8% participated in CACFP, 21.7% were center-based, and 78.3% were home-based. Overall, CACFP participation was related to the higher implementation of CACFP requirements for foods served (P < 0.004 for all) and receiving professional development on nutrition (P < 0.012). In home-based ECEs only, CACFP participation was related to a higher prevalence of serving meals family-style (P = 0.002); however, these practices had low implementation overall.Conclusion and ImplicationsFindings suggest strengthening of requirements to include staff mealtime behaviors beyond service of healthful foods. Improving CACFP enrollment and including CACFP standards in state licensing requirements may be key strategies for improving nutrition practices in ECEs. 相似文献