全文获取类型
收费全文 | 4084篇 |
免费 | 229篇 |
国内免费 | 56篇 |
专业分类
耳鼻咽喉 | 39篇 |
儿科学 | 116篇 |
妇产科学 | 63篇 |
基础医学 | 456篇 |
口腔科学 | 173篇 |
临床医学 | 350篇 |
内科学 | 1016篇 |
皮肤病学 | 46篇 |
神经病学 | 466篇 |
特种医学 | 187篇 |
外科学 | 611篇 |
综合类 | 28篇 |
一般理论 | 1篇 |
预防医学 | 291篇 |
眼科学 | 66篇 |
药学 | 237篇 |
1篇 | |
中国医学 | 5篇 |
肿瘤学 | 217篇 |
出版年
2023年 | 35篇 |
2022年 | 72篇 |
2021年 | 127篇 |
2020年 | 76篇 |
2019年 | 108篇 |
2018年 | 117篇 |
2017年 | 78篇 |
2016年 | 121篇 |
2015年 | 97篇 |
2014年 | 173篇 |
2013年 | 178篇 |
2012年 | 287篇 |
2011年 | 297篇 |
2010年 | 173篇 |
2009年 | 166篇 |
2008年 | 217篇 |
2007年 | 264篇 |
2006年 | 225篇 |
2005年 | 229篇 |
2004年 | 167篇 |
2003年 | 154篇 |
2002年 | 153篇 |
2001年 | 68篇 |
2000年 | 44篇 |
1999年 | 50篇 |
1998年 | 64篇 |
1997年 | 78篇 |
1996年 | 76篇 |
1995年 | 53篇 |
1994年 | 38篇 |
1993年 | 38篇 |
1992年 | 15篇 |
1991年 | 25篇 |
1990年 | 22篇 |
1989年 | 24篇 |
1988年 | 35篇 |
1987年 | 25篇 |
1986年 | 29篇 |
1985年 | 17篇 |
1984年 | 15篇 |
1983年 | 17篇 |
1982年 | 17篇 |
1981年 | 10篇 |
1980年 | 16篇 |
1979年 | 5篇 |
1978年 | 15篇 |
1977年 | 13篇 |
1976年 | 10篇 |
1975年 | 7篇 |
1969年 | 5篇 |
排序方式: 共有4369条查询结果,搜索用时 0 毫秒
1.
2.
3.
Willy Baccaglini Felipe A. Glina Cristiano Linck Pazeto Luis G. Medina Fernando Korkes Wanderley M. Bernardo Rene Sotelo Sidney Glina Giancarlo Marra Marco Moschini Xavier Cathelineau Rafael Sanchez-Salas 《Clinical genitourinary cancer》2021,19(1):3-11.e1
This meta-analysis focuses on the accuracy of upgrading to clinically significant prostate cancer (PCa) by multiparametric magnetic resonance imaging-targeted biopsy (MRI-TB) versus systematic biopsy (SB). We searched the Medline, Embase, Cochrane Central Register of Controlled Trials, Web of Science, Scopus, and Literatura Latino Americana em Ciências da Saúde databases through January 2020 for comparative, retrospective/prospective, paired-cohort, and randomized clinical trials with paired comparisons. The population consisted of patients with low-risk PCa in active surveillance with at least 1 index lesion on imaging. We evaluated the quality of evidence by using the Quality Assessment of Diagnostic Accuracy Studies-2 score. Group comparisons considered the differences between the area under the curve summary receiver operating characteristic curve in a 2-tailed method. We also compared the positive predictive value of the best single method (MRI-TB or SB) and the referral study test (combined biopsy, a combination of MRI-TB and SB). The meta-analysis included 6 studies enrolling 741 patients. The pooled sensitivity for the 2 groups was 0.79 (95% confidence interval, 0.74-0.83; I2 = 75%) and 0.67 (95% confidence interval, 0.63-0.74; I2 = 55.4%), respectively. The area under the curve for the MRI-TB and SB groups were 0.99 and 0.92 (P < .001), respectively. The positive predictive value for the MRI-TB and combined biopsy groups were similar. The accumulated evidence suggests better results for MRI-TB compared with SB. Therefore, use of MRI-TB alone may be preferable in patients in active surveillance harboring low-risk PCa. 相似文献
4.
5.
6.
7.
Carel Bron Michel Wensing Jo LM Franssen Rob AB Oostendorp 《BMC musculoskeletal disorders》2007,8(1):107
Background
Shoulder disorders are a common health problem in western societies. Several treatment protocols have been developed for the clinical management of persons with shoulder pain. However available evidence does not support any protocol as being superior over others. Systematic reviews provide some evidence that certain physical therapy interventions (i.e. supervised exercises and mobilisation) are effective in particular shoulder disorders (i.e. rotator cuff disorders, mixed shoulder disorders and adhesive capsulitis), but there is an ongoing need for high quality trials of physical therapy interventions. Usually, physical therapy consists of active exercises intended to strengthen the shoulder muscles as stabilizers of the glenohumeral joint or perform mobilisations to improve restricted mobility of the glenohumeral or adjacent joints (shoulder girdle). It is generally accepted that a-traumatic shoulder problems are the result of impingement of the subacromial structures, such as the bursa or rotator cuff tendons. Myofascial trigger points (MTrPs) in shoulder muscles may also lead to a complex of symptoms that are often seen in patients diagnosed with subacromial impingement or rotator cuff tendinopathy. Little is known about the treatment of MTrPs in patients with shoulder disorders. 相似文献8.
M D Blanco M V Bernardo R L Sastre R Olmo E Mu?iz J M Teijón 《European journal of pharmaceutics and biopharmaceutics》2003,55(2):229-236
Poly(epsilon-caprolactone) microspheres containing bupivacaine were prepared by the spray-drying process. The average size of drug loaded microspheres was less than 3 microm in diameter, and the percentage of entrapment efficiency was 91 +/- 3%. In vitro drug release kinetic in phosphate buffer at 37 degrees C showed a hyperbolic profile, with a burst-effect during the first hour. Subcutaneous injection of bupivacaine-loaded microspheres in the back of rats caused an increase in drug concentration in plasma. Maximum bupivacaine concentration in plasma was 237 +/- 58 ng/ml at 105 h, and drug was detected in plasma for 16 days. The half-life time of the drug was increased by more than 125 times with regard to that of the drug administered in a solution by intraperitoneal injection. After 30 days of injection, a mass formed by microspheres surrounded by a thin fibrous capsule was observed. Small blood vessels and multinucleate foreign body giant cells with macrophagic function around microspheres were detected. After 60 days of injection a subcutaneous mass was also observed, which was formed of more degraded dispersed microspheres in conjunctive tissue, which had a normal structure. Thus, bupivacaine-loaded poly(epsilon-caprolactone) microspheres could be considered as a device to be used in the treatment of severe pain that is not responsive to opioids for example in cancer-related syndromes or in intractable herpetic neuralgia. 相似文献
9.
10.