全文获取类型
收费全文 | 189篇 |
免费 | 11篇 |
专业分类
儿科学 | 2篇 |
基础医学 | 45篇 |
口腔科学 | 2篇 |
临床医学 | 11篇 |
内科学 | 46篇 |
皮肤病学 | 6篇 |
神经病学 | 49篇 |
特种医学 | 1篇 |
外科学 | 9篇 |
综合类 | 3篇 |
预防医学 | 7篇 |
眼科学 | 2篇 |
药学 | 13篇 |
肿瘤学 | 4篇 |
出版年
2022年 | 1篇 |
2021年 | 4篇 |
2020年 | 1篇 |
2019年 | 3篇 |
2018年 | 2篇 |
2016年 | 2篇 |
2015年 | 2篇 |
2014年 | 5篇 |
2013年 | 5篇 |
2012年 | 2篇 |
2011年 | 4篇 |
2010年 | 5篇 |
2009年 | 8篇 |
2008年 | 6篇 |
2007年 | 6篇 |
2006年 | 10篇 |
2005年 | 10篇 |
2004年 | 12篇 |
2003年 | 8篇 |
2002年 | 6篇 |
2001年 | 10篇 |
2000年 | 10篇 |
1999年 | 8篇 |
1998年 | 2篇 |
1997年 | 5篇 |
1995年 | 1篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1992年 | 6篇 |
1991年 | 6篇 |
1990年 | 5篇 |
1989年 | 6篇 |
1988年 | 6篇 |
1987年 | 7篇 |
1986年 | 4篇 |
1985年 | 3篇 |
1984年 | 5篇 |
1983年 | 3篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1977年 | 1篇 |
1970年 | 2篇 |
1967年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有200条查询结果,搜索用时 281 毫秒
1.
The presence of 3 different neuropeptide mRNAs with a strict cell-specific expression in vivo was investigated in 13 tumor cell lines from neuroendocrine and in 23 tumor cell lines from non-neuroendocrine origin. Northern blots showed no expression of mRNA for vasopressin (VP) in the 36 tested cell lines. Very low oxytocin (OT) mRNA hybridization signals were detected in the rat pituitary tumor cell line GH4C2 and the rat pancreas tumor cell line RIN5. Both the rat pituitary tumor cell line AtT-20 and the human myeloid leukemia cell line K562, contained proopiomelanocortin (POMC) mRNA. The low incidence of VP, OT and POMC gene expression in the tested tumor cell lines was not influenced by treatments inducing differentiation. In contrast, the cholecystokinin (CCK) gene which is widely present in nervous and endocrine systems was abundantly expressed in the human primitive neuroepithelioma cell line SK-N-MC and its clonal derivative SK-N-MC-IX-C. The results indicate that the expression of neuropeptide genes is very rare in tumor cell lines. The lack of expression in undifferentiated cells agrees with the appearance of expression after day 13 of the embryogenesis when maturation of neurons begins. 相似文献
2.
3.
4.
5.
Heidi M B Lesscher Emily Hoogveld J Peter H Burbach Jan M van Ree Mirjam A F M Gerrits 《European neuropsychopharmacology》2005,15(1):31-37
The endogenous cannabinoid system is a relatively novel discovered system consisting of cannabinoid CB1 receptors, which are expressed both in the periphery and in the central nervous system, peripheral cannabinoid CB2 receptors and endogenous cannabinoids, which are anandamide and 2-arachidonyl glycerol. The cannabinoid CB1 receptors have recently been implicated in rewarding aspects of not only the cannabinoid drug Delta9-tetrahydrocannabinol (Delta9-THC), but also of other drugs of abuse, including cocaine. The present study was designed to further investigate the role of CB1 receptors in reward-related effects of cocaine. Using the CB1 receptor selective antagonist SR141716A, the involvement of CB1 receptors in cocaine reinforcement was determined by intravenous cocaine self-administration. In addition, the effects of the CB1 receptor selective antagonist SR141716A upon the development of cocaine-induced behavioural sensitization were investigated. SR141716A did not affect cocaine reinforcement nor did it affect the development of behavioural sensitization to the locomotor stimulant effects of cocaine. These findings suggest that CB1 receptors are not involved in acute cocaine reinforcement nor in cocaine-induced behavioural sensitization. 相似文献
6.
Tolbert G. Nyenswah Mosaka Fallah Geoffrey M. Calvert Stanley Duwor E. Dutch Hamilton Vishwesh Mokashi Sampson Arzoaquoi Emmanuel Dweh Ryan Burbach Diane Dlouhy John E. Oeltmann Patrick K. Moonan 《Emerging infectious diseases》2015,21(7):1253-1256
Lack of trust in government-supported services after the death of a health care worker with symptoms of Ebola resulted in ongoing Ebola transmission in 2 Liberia counties. Ebola transmission was facilitated by attempts to avoid cremation of the deceased patient and delays in identifying and monitoring contacts. 相似文献
7.
Klemens Horst Silke Ganzera Wolfgang Kaisers Johanna Munding Berenike Flott-Rahmel Andrea Tannapfel Hubert Zirngibl 《Pathology, research and practice》2013
The MRE11/RAD50/NIBRIN complex, a protein complex that repairs DNA double-strand breaks, could serve as an early marker for new lesions in pancreatic cancer. We determined the expression of MRE11, RAD50 and NIBRIN, and their possible prognostic value regarding survival. 相似文献
8.
9.
10.
Kristel T. E. Kleijer Michael J. Schmeisser Dilja D. Krueger Tobias M. Boeckers Peter Scheiffele Thomas Bourgeron Nils Brose J. Peter H. Burbach 《Psychopharmacology》2014,231(6):1037-1062