全文获取类型
收费全文 | 249篇 |
免费 | 11篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 6篇 |
妇产科学 | 7篇 |
基础医学 | 22篇 |
口腔科学 | 1篇 |
临床医学 | 22篇 |
内科学 | 48篇 |
皮肤病学 | 3篇 |
神经病学 | 18篇 |
特种医学 | 18篇 |
外科学 | 43篇 |
预防医学 | 22篇 |
眼科学 | 10篇 |
药学 | 9篇 |
中国医学 | 1篇 |
肿瘤学 | 17篇 |
出版年
2023年 | 1篇 |
2022年 | 4篇 |
2021年 | 5篇 |
2020年 | 4篇 |
2019年 | 4篇 |
2018年 | 6篇 |
2017年 | 5篇 |
2016年 | 5篇 |
2015年 | 6篇 |
2014年 | 8篇 |
2013年 | 9篇 |
2012年 | 22篇 |
2011年 | 19篇 |
2010年 | 9篇 |
2009年 | 6篇 |
2008年 | 9篇 |
2007年 | 18篇 |
2006年 | 14篇 |
2005年 | 21篇 |
2004年 | 21篇 |
2003年 | 8篇 |
2002年 | 7篇 |
2001年 | 6篇 |
2000年 | 8篇 |
1999年 | 3篇 |
1996年 | 3篇 |
1993年 | 1篇 |
1992年 | 7篇 |
1991年 | 5篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1988年 | 2篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1980年 | 1篇 |
1979年 | 2篇 |
1978年 | 1篇 |
1976年 | 1篇 |
1975年 | 2篇 |
1974年 | 1篇 |
排序方式: 共有260条查询结果,搜索用时 15 毫秒
1.
Pseudomixoma peritoneal tipo adenomucinosis peritoneal diseminada con imágenes radiológicas atípicas
Manuel Vallalta Morales Ángel Segura Huerta Carmen Gil Adiego Laura Palomar Abad Jorge Molina Saera Roberto Díaz Beveridge 《Clinical & translational oncology》2004,6(3):173-175
Pseudomyxoma peritonei is an unusual condition that has caused much confusion regarding its aetiology, clinical manifestations, treatment and prognosis. It is characterised by mucinous ascites and diffuse mucinous invasions of the peritoneum. Three histological subtypes have been defined: a) disseminated peritoneal adenomucinosis (peritoneal lesions composed of abundant extra-cellular mucin containing scant simple-to-focally-proliferating mucinous epithelium with little cytological atypia or mitotic activity); b) peritoneal mucinous carcinomatosis (peritoneal lesions composed of more abundant mucinous epithelium with the architectural and cytological features of carcinoma); and c) an intermediate group. The different histological subtypes have different prognoses. We report a case of disseminated peritoneal adenomatosis, and discuss its clinical management. 相似文献
2.
3.
Carlos A. Jiménez Ruiz Daniel Buljubasich Juan Antonio Riesco Miranda Agustín Acuña Izcaray José Ignacio de Granda Orive José Miguel Chatkin Gustavo Zabert Alfredo Guerreros Benavides Nelson Paez Espinel Valeri Noé Efraín Sánchez-Angarita Ingrid Núñez-Sánchez Raúl H. Sansores Alejandro Casas Andrés Palomar Lever Inmaculada Alfageme Michavila 《Archivos de bronconeumología》2017,53(11):622-628
The ALAT and SEPAR Treatment and Control of Smoking Groups have collaborated in the preparation of this document which attempts to answer, by way of PICO methodology, different questions on health interventions for helping COPD patients to stop smoking.The main recommendations are: (i) moderate-quality evidence and strong recommendation for performing spirometry in COPD patients and in smokers with a high risk of developing the disease, as a motivational tool (particularly for showing evidence of lung age), a diagnostic tool, and for active case-finding; (ii) high-quality evidence and strong recommendation for using intensive dedicated behavioral counselling and drug treatment for helping COPD patients to stop smoking; (iii) high-quality evidence and strong recommendation for initiating interventions for helping COPD patients to stop smoking during hospitalization with improvement when the intervention is prolonged after discharge, and (iv) high-quality evidence and strong recommendation for funding treatment of smoking in COPD patients, in view of the impact on health and health economics. 相似文献
4.
Margarida Corominas-Roso Gloria Palomar Roser Ferrer Alberto Real Mariana Nogueira Montserrat Corrales Miguel Casas Josep Antoni Ramos-Quiroga 《The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)》2015,18(9)
Background:
Differences in the cortisol response have been reported between children exhibiting the inattentive and hyperactive/impulsive subtypes of attention deficit hyperactivity disorder. However, there is no such information about adults. The aim of the present study was to determine the possible differences between the combined and inattentive subtypes in the cortisol response to stress.Methods:
Ninety-six adults with attention deficit hyperactivity disorder, 38 inattentive and 58 combined, without any medical or psychiatric comorbidities and 25 healthy controls were included. The Trier Social Stress Test was used to assess physiological stress responses. Clinical data and subjective stress levels, including the Perceived Stress Scale, were also recorded.Results:
No significant differences in the cortisol response to the Trier Social Stress Test were found between patients and controls. However, albeit there were no basal differences, lower cortisol levels at 15 (P=.015), 30 (P=.015), and 45 minutes (P=.045) were observed in the combined compared with the inattentive subtype after the stress induction; these differences disappeared 60 minutes after the stress. In contrast, the subjective stress responses showed significant differences between attention deficit hyperactivity disorder patients and controls (P<.001), but no differences were seen between attention deficit hyperactivity disorder subtypes. In turn, subjective stress measures, such as the Perceived Stress Scale, positively correlated with the whole cortisol stress response (P<.027).Conclusions:
Both the combined and inattentive attention deficit hyperactivity disorder adults exhibited a normal cortisol response to stress when challenged. Nevertheless, the inattentive patients displayed a higher level of cortisol after stress compared with the combined patients. Despite the differences in the cortisol response, adults with attention deficit hyperactivity disorder reported high levels of subjective stress in their every-day life. 相似文献5.
Tjallie van der Kooi Hugo Sax Didier Pittet Jaap van Dissel Birgit van Benthem Bernhard Walder Vanessa Cartier Lauren Clack Sabine de Greeff Martin Wolkewitz Stefanie Hieke Hendriek Boshuizen Jan van de Kassteele Annemie Van den Abeele Teck Wee Boo Magda Diab-Elschahawi Uga Dumpis Camelia Ghita Susan FitzGerald Tatjana Lejko Kris Leleu Mercedes Palomar Martinez Olga Paniara Márta Patyi Paweł Schab Annibale Raglio Emese Szilágyi Mirosław Ziętkiewicz Albert W. Wu Hajo Grundmann Walter Zingg On behalf of the PROHIBIT consortium 《Intensive care medicine》2018,44(1):48-60
Purpose
To test the effectiveness of a central venous catheter (CVC) insertion strategy and a hand hygiene (HH) improvement strategy to prevent central venous catheter-related bloodstream infections (CRBSI) in European intensive care units (ICUs), measuring both process and outcome indicators.Methods
Adult ICUs from 14 hospitals in 11 European countries participated in this stepped-wedge cluster randomised controlled multicentre intervention study. After a 6 month baseline, three hospitals were randomised to one of three interventions every quarter: (1) CVC insertion strategy (CVCi); (2) HH promotion strategy (HHi); and (3) both interventions combined (COMBi). Primary outcome was prospective CRBSI incidence density. Secondary outcomes were a CVC insertion score and HH compliance.Results
Overall 25,348 patients with 35,831 CVCs were included. CRBSI incidence density decreased from 2.4/1000 CVC-days at baseline to 0.9/1000 (p < 0.0001). When adjusted for patient and CVC characteristics all three interventions significantly reduced CRBSI incidence density. When additionally adjusted for the baseline decreasing trend, the HHi and COMBi arms were still effective. CVC insertion scores and HH compliance increased significantly with all three interventions.Conclusions
This study demonstrates that multimodal prevention strategies aiming at improving CVC insertion practice and HH reduce CRBSI in diverse European ICUs. Compliance explained CRBSI reduction and future quality improvement studies should encourage measuring process indicators.6.
7.
8.
Emilio Rodrigo Juan C. Ruiz Gema Fernández‐Fresnedo Maria D. Fernández Celestino Piñera Rosa Palomar Elena Monfá Carlos Gómez‐Alamillo Manuel Arias 《Clinical transplantation》2013,27(2):E177-E183
Although cystatin C (Cys) and albuminuria (Alb) are predictors of end‐stage renal disease in the general population, there are limited data about the performance of these markers alone or combined with respect to the prediction of the kidney transplant outcome. We assessed the ability of one‐yr creatinine (Cr), MDRD equation, Cys, Hoek equation, Alb, the logarithm of albuminuria (LogAlb), and two products of these variables for predicting death‐censored graft loss (DCGL) in 127 kidney transplant recipients. Mean follow‐up time was 5.6 ± 1.7 yr. During this time, 18 patients developed DCGL. The area under the receiver operating characteristic curve for DCGL ranged from 71.1% to 85.4%, with Cys*LogAlb being the best predictor. Cys‐based variables and variables combining LogAlb and renal function estimates have better discrimination ability than Cr‐based variables alone. After multivariate analysis, quartiles of all one‐yr variables (except of Cr and MDRD) were independent predictors for DCGL. Predictors combining Alb and a Cr‐ or Cys‐based estimate of renal function performed better than those markers alone to predict DCGL. Cys‐based predictors performed better than Cr‐based predictors. Using a double‐marker in kidney transplantation, it is possible to identify the highest risk group in which to prioritize specialty care. 相似文献
9.
In this paper, a restricted domain question answering (QA) system is described. The design architecture of this QA system and the features that allow the adaptation of the QA system to the medical domain are also presented. The advantages of this QA system include the simple process of defining the question taxonomy answered by the system as well as the possibility of locally or remotely managed document collections. The main computing methods of the QA system are based on the application of natural language processing (NLP) techniques to infer the logic forms and on the treatment of the logic forms. The knowledge of the system is acquired through the use of two different resources: Unified Medical Language System (UMLS) to handle the medical terminology and WordNet to manage the open-domain terminology. 相似文献
10.
Josep Antoni Ramos-Quiroga Margarida Corominas-Roso Gloria Palomar Nuria Gomez-Barros Marta Ribases Cristina Sanchez-Mora Rosa Bosch Mariana Nogueira Montserrat Corrales Sergi Valero Miguel Casas 《Psychopharmacology》2014,231(7):1389-1395