全文获取类型
收费全文 | 1127篇 |
免费 | 100篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 26篇 |
妇产科学 | 23篇 |
基础医学 | 130篇 |
口腔科学 | 20篇 |
临床医学 | 141篇 |
内科学 | 183篇 |
皮肤病学 | 10篇 |
神经病学 | 236篇 |
特种医学 | 22篇 |
外科学 | 238篇 |
综合类 | 13篇 |
预防医学 | 41篇 |
眼科学 | 41篇 |
药学 | 55篇 |
肿瘤学 | 45篇 |
出版年
2023年 | 6篇 |
2022年 | 10篇 |
2021年 | 26篇 |
2020年 | 16篇 |
2019年 | 22篇 |
2018年 | 40篇 |
2017年 | 25篇 |
2016年 | 25篇 |
2015年 | 23篇 |
2014年 | 35篇 |
2013年 | 35篇 |
2012年 | 67篇 |
2011年 | 68篇 |
2010年 | 39篇 |
2009年 | 33篇 |
2008年 | 61篇 |
2007年 | 70篇 |
2006年 | 69篇 |
2005年 | 52篇 |
2004年 | 66篇 |
2003年 | 46篇 |
2002年 | 48篇 |
2001年 | 27篇 |
2000年 | 35篇 |
1999年 | 26篇 |
1998年 | 13篇 |
1997年 | 13篇 |
1996年 | 11篇 |
1995年 | 13篇 |
1994年 | 13篇 |
1993年 | 8篇 |
1992年 | 19篇 |
1991年 | 27篇 |
1990年 | 22篇 |
1989年 | 10篇 |
1988年 | 13篇 |
1987年 | 13篇 |
1986年 | 10篇 |
1985年 | 11篇 |
1984年 | 4篇 |
1983年 | 6篇 |
1981年 | 4篇 |
1979年 | 5篇 |
1977年 | 5篇 |
1975年 | 3篇 |
1974年 | 3篇 |
1969年 | 3篇 |
1968年 | 3篇 |
1966年 | 4篇 |
1964年 | 3篇 |
排序方式: 共有1230条查询结果,搜索用时 796 毫秒
1.
2.
3.
Although fever may induce seizures, especially in children, its occurrence following epileptic spells has been rarely described, except from generalized convulsive status epilepticus. We present two patients suffering from focal seizures accompanied by episodes of post-ictal fever, and review similar reports in the literature of the last 40 years. Temperature changes following non-convulsive seizures might be induced by gene upregulation occurring in the hypothalamus, the nucleus tractus solitarius, or in other brain regions, producing a local inflammatory response. Direct propagation of electrical discharges seems less consistent with the timing of development of this symptom. Heterogeneity of reported clinical features argues against the assumption of a definite localizing or lateralizing value for post-ictal fever. 相似文献
4.
We examined the in vivo mechanisms of amylin-induced resistance in concious rats (n = 18). During 180-min euglycemic insulin-clamp (21.5 pmol.kg-1.min-1) studies, amylin (50, 200, or 500 pmol.kg-1.min-1; plasma concentration from 3 x 10(-10) to 9 x 10(-9) M) infusion determined a 19-27% reduction in glucose uptake (117.8 +/- 7.0 vs. 145.8 +/- 11.0, 107.1 +/- 9.2 vs. 145.1 +/- 6.7, and 105.0 +/- 7.2 vs. 144.4 +/- 7.0 mumol.kg-1.min-1 at 50, 200, or 500 pmol.kg-1.min-1, respectively, P less than 0.01) versus insulin alone, whereas 10-pmol.kg-1.min-1 amylin infusion (plasma concn 5 x 10(-11) M) failed to affect insulin-mediated glucose disposal. After amylin infusion, the contribution of whole-body glycolysis to overall glucose disposal increased from 43-48 to 62-79%, whereas muscle glycogen synthesis decreased significantly at all peptide concentrations greater than 3 x 10(-10) M, completely accounting for the decrease in glucose uptake. Skeletal muscle glucose-6-phosphate concentration rose from 0.219 +/- 0.038 mumol/g (insulin alone) to 0.350 +/- 0.018, 0.440 +/- 0.020, and 0.505 +/- 0.035 mumol/g (insulin plus amylin at 50, 200, or 500 pmol.kg-1.min-1, P less than 0.01). Suppression of hepatic glucose production by insulin was unaffected by a 50-pmol.kg-1.min-1 amylin infusion (18.5 +/- 4.3 vs. 21.7 +/- 2.9 mumol.kg-1.min-1), whereas it was slightly but significantly impaired by amylin infusion at 200 pmol.kg-1.min-1 (17.8 +/- 3.9 vs. 24.7 +/- 4.5 mumol.kg-1.min-1, P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
5.
6.
7.
8.
Renal function studies and measurements of in vivo plasma renin activity (PRA), kidney renin content, and renin secretion by isolated, perfused kidneys were performed in spontaneously diabetic and nondiabetic BioBreeding/Worcester (BB/W) rats. Diabetic animals evidenced hyperglycemia, glycosuria, and plasma volume expansion. After dietary sodium deprivation, plasma volume fell to levels equivalent to those of sodium-deprived, nondiabetic rats. Dietary sodium deprivation evoked a larger proportional increase in PRA among diabetic than nondiabetic animals, although PRA before sodium restriction was equivalent in the two groups. Basal renin release (RR) was higher from isolated, perfused kidneys from diabetic rats than from nondiabetic kidneys. Diabetic kidneys, moreover, displayed increased kidney renin content (KRC). By contrast, while isoproterenol (10(-5) M) stimulated a nearly fivefold increment in RR from nondiabetic, perfused kidneys, a negligible effect was observed in diabetic kidneys. The dose-response curve of renin secretion (as a proportion of total renal content) in response to isoproterenol was shifted downward. Hence, while KRC and spontaneous RR by isolated, perfused kidneys were increased, the increment in PRA with salt depletion and the renin-secretory response to isoproterenol in vitro were impaired. We propose that specific defects in renin secretion, in particular, the response to beta-adrenergic stimulation, may be operative in diabetes. 相似文献
9.
10.
Schindler I Rice NJ McIntosh RD Rossetti Y Vighetto A Milner AD 《Nature neuroscience》2004,7(7):779-784
When we reach out to pick something up, our arm is directed to the target by visuomotor networks in the cortical dorsal stream. However, our reach trajectories are influenced also by nontarget objects, which might be construed as potential obstacles. We tested two patients with bilateral dorsal-stream (parietal lesions, both of whom were impaired at pointing to visual stimuli (optic ataxia). We asked them to reach between two cylinders, which varied in location from trial to trial. We found that the patients' reaches remained invariant with changes in obstacle location. In a control task when they were asked to point midway between the two objects, however, their responses shifted in an orderly fashion. We conclude that the dorsal stream provides the visual guidance we automatically build into our movements to avoid potential obstacles, as well as that required to ensure arrival at the target. 相似文献