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Prof. Leonardo Marzio MD Matteo Neri MD Anna Maria Di Giammarco MD Franco Cuccurullo MD Giorgio Assuero Lanfranchi MD 《Digestive diseases and sciences》1986,31(4):349-354
The effect of dopamine on human gastric and small intestinal interdigestive motility was investigated in 12 subjects. Intestinal motility was recorded by means of a four-lumen polyvinyl probe with four open tips located 15 cm apart, continuously perfused with distilled water. In each subject during the same study, after recording two consecutive spontaneous phase III of migrating myoelectrical complexes and when a phase II appeared, dopamine was infused intravenously twice in a dose of 5 g/kg/min for 15 min with an interval of 20 min between each infusion. In six subjects, the second dopamine infusion was preceded by a treatment with sulpiride (10 mg, intravenously, as bolus) or domperidone (10 mg, intravenously, as bolus), each considered a highly selective dopamine antagonist. The results show that dopamine stimulates duodenal motility producing a pattern similar to that observed in phase III of spontaneously occurring migrating myoelectrical complexes. The second dopamine infusion reproduced in all cases the same pattern of motility as observed during the first infusion. Sulpiride and domperidone prevented the effect of dopamine in all cases. It is therefore suggested that dopamine-induced duodenal motility may involve specific dopaminergic receptors. 相似文献
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Alessia Gimelli Riccardo Liga Assuero Giorgetti Brunella Favilli Emilio Maria Pasanisi Paolo Marzullo 《Journal of nuclear cardiology》2016,23(4):728-736
Background
An interaction between coronary anatomy, myocardial perfusion, and left ventricular (LV) functional parameters in the development of mechanical LV dyssynchrony (LVD) has been suggested. This study examined the correlates of LVD in a large sample size of patients with known or suspected coronary artery disease (CAD) using cadmium-zinc-telluride camera.Methods
Six-hundred and fifty-seven consecutive patients who underwent myocardial perfusion imaging (MPI) and coronary angiography were included. Coronary stenosis >70% was considered significant. LV perfusion and functional parameters were computed from MPI images. The presence of significant LVD was evaluated by phase standard deviation and histogram bandwidth.Results
415/657 (63%) patients had significant CAD. LVD was present in 247 (38%) patients and was associated with the presence of a higher CAD burden (P < .001), more impaired measures of LV perfusion (P < .001), contractile function (P < .001), and larger LV volumes (P < .001). By multivariate analysis, the LV end-systolic volume index (P < .001) and ischemic burden (P < .001) were the strongest predictors of LVD independent of CAD extent and LV systolic dysfunction.Conclusions
LVD is frequent in patients undergoing MPI for suspected or known CAD. Its presence is independent of CAD burden and LV systolic dysfunction, but is dependent on the presence of myocardial perfusion abnormalities and LV end-systolic volume.4.
Marini C Giorgetti A Gimelli A Kusch A Sereni N L'abbate A Marzullo P Sambuceti G 《European journal of nuclear medicine and molecular imaging》2005,32(6):682-688
Purpose This study aims to investigate the relationship between cardiac sympathetic nervous function (CSNF) and myocardial perfusion/function in patients with heart failure (HF) due to dilated cardiomyopathy (DCM) or ischaemic heart disease (CAD).Methods Twenty patients (10 DCM, 10 CAD, 17 males, age 69±5 years) with NYHA class IIIb HF were studied. CSNF was evaluated by early/delayed 123I-metaiodobenzylguanidine (MIBG) uptake and regional washout (WO). Myocardial perfusion and function were evaluated by 99mTc-tetrofosmin gated single-photon emission tomography (G-SPECT) using a 20-segment model for 400 segments. In each segment, regional MIBG WO was computed as (count density in early images–count density in delayed images/count density in early images)×100.Results DCM and CAD showed similar summed rest perfusion score (6.7±5 vs 9.5±5, p=NS) and mean ejection fraction values (29±7% vs 30±9%, p=NS). By contrast, the summed thickening score was higher in DCM than in CAD patients (26±7 vs 17±6, p<0.05). QGS analysis identified akinesis/dyskinesis in 129/137 (94%) severely hypoperfused segments which were considered as damaged. According to the underlying aetiology of HF, marked differences in regional MIBG WO were observed. In fact, within the CAD group, regional MIBG WO was lower in reference than in damaged segments (38±21% vs 46±19%, p<0.05). By contrast, in DCM patients, regional MIBG WO was faster in reference than in damaged segments (49±18% vs 41±30%, p<0.05). When the two groups were directly compared, regional MIBG WO from damaged areas was similar irrespective of the underlying disease, while it was faster in DCM than in CAD patients from reference segments.Conclusion These data confirm the hypothesis that the presence of myocardial necrosis in HF due to CAD and the consequent loss of neuronal endings cause alterations in regional MIBG WO different from those observed in DCM. 相似文献
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Gimelli A Bottai M Genovesi D Giorgetti A Di Martino F Marzullo P 《European journal of nuclear medicine and molecular imaging》2012,39(1):83-90
Purpose
Appropriate use of SPECT imaging is regulated by evidence-based guidelines and appropriateness criteria in an effort to limit the burden of radiation administered to patients. We aimed at establishing whether the use of a low dose for stress–rest single-day nuclear myocardial perfusion imaging on an ultrafast (UF) cardiac gamma camera using cadmium-zinc-telluride solid-state detectors could be used routinely with the same accuracy obtained with standard doses and conventional cameras. 相似文献7.
Paolo Marzullo Gianmario Sambuceti Oberdan Parodi Alessia Gimelli Eugenio Picano Assuero Giorgetti Antonio L’Abbate 《Journal of nuclear cardiology》1995,2(4):309-316
Background
Whether the combined analysis of rest 201Tl and sestamibi uptake provides additional information regarding myocardial viability in patients with coronary artery disease is still to be investigated. 相似文献8.
Alessia Gimelli Riccardo Liga Dario Genovesi Assuero Giorgetti Annette Kusch Paolo Marzullo 《European journal of nuclear medicine and molecular imaging》2014,41(5):946-955
Purpose
To evaluate the relationships among myocardial sympathetic innervation, perfusion and mechanical synchronicity assessed with cardiac cadmium-zinc-telluride (CZT) scintigraphy.Methods
A group of 29 patients underwent an evaluation of myocardial perfusion with 99mTc-tetrofosmin CZT scintigraphy and adrenergic innervation with 123I-metaiodobenzylguanidine (MIBG) CZT scintigraphy. The summed rest score (SRS), motion score (SMS) and thickening score (STS), as well as the summed 123I-MIBG defect score (SS-MIBG), were determined. Regional tracer uptake for both 99mTc-tetrofosmin and 123I-MIBG was also calculated. Finally, the presence of significant myocardial mechanical dyssynchrony was evaluated in phase analysis on gated CZT images and the region of latest mechanical activation identified.Results
Significant mechanical dyssynchrony was present in 17 patients (59 %) and associated with higher SRS (P?=?0.030), SMS (P?<?0.001), STS (P?=?0.003) and early SS-MIBG (P?=?0.037) as well as greater impairments in left ventricular ejection fraction (P?<?0.001) and end-diastolic volume (P?<?0.001). In multivariate analysis a higher end-diastolic volume remained the only predictor of mechanical dyssynchrony (P?=?0.047). Interestingly, while in the whole population regional myocardial perfusion and adrenergic activity were strongly correlated (R?=?0.68), in patients with mechanical dyssynchrony the region of latest mechanical activation was predicted only by greater impairment in regional 123I-MIBG uptake (P?=?0.012) that overwhelmed the effect of depressed regional perfusion.Conclusion
Left ventricular mechanical dyssynchrony is associated with greater depression in contractile function and greater impairments in regional myocardial perfusion and sympathetic activity. In patients with dyssynchrony, the region of latest mechanical activation is characterized by a significantly altered adrenergic tone. 相似文献9.
Assuero Giorgetti Annette Kusch Mirta Casagranda Irene D’Aragona Tagliavia Paolo Marzullo 《Journal of nuclear cardiology》2010,17(2):276-285
Background
We previously demonstrated that early (15′, T1) post-stress myocardial imaging with Tetrofosmin could be more accurate than standard acquisitions (45′, T2) in identifying coronary artery disease. 相似文献10.
Alessia Gimelli MD Riccardo Liga MD Assuero Giorgetti MD Mirta Casagranda RT Paolo Marzullo MD 《Journal of nuclear cardiology》2014,21(6):1181-1190