全文获取类型
收费全文 | 1327篇 |
免费 | 84篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 55篇 |
妇产科学 | 76篇 |
基础医学 | 172篇 |
口腔科学 | 16篇 |
临床医学 | 129篇 |
内科学 | 261篇 |
皮肤病学 | 27篇 |
神经病学 | 109篇 |
特种医学 | 21篇 |
外科学 | 117篇 |
综合类 | 24篇 |
一般理论 | 1篇 |
预防医学 | 189篇 |
眼科学 | 22篇 |
药学 | 95篇 |
中国医学 | 21篇 |
肿瘤学 | 74篇 |
出版年
2024年 | 1篇 |
2023年 | 22篇 |
2022年 | 63篇 |
2021年 | 69篇 |
2020年 | 36篇 |
2019年 | 52篇 |
2018年 | 57篇 |
2017年 | 45篇 |
2016年 | 38篇 |
2015年 | 51篇 |
2014年 | 67篇 |
2013年 | 67篇 |
2012年 | 114篇 |
2011年 | 98篇 |
2010年 | 67篇 |
2009年 | 42篇 |
2008年 | 74篇 |
2007年 | 75篇 |
2006年 | 75篇 |
2005年 | 70篇 |
2004年 | 52篇 |
2003年 | 53篇 |
2002年 | 43篇 |
2001年 | 10篇 |
2000年 | 8篇 |
1999年 | 5篇 |
1998年 | 1篇 |
1997年 | 8篇 |
1996年 | 3篇 |
1995年 | 1篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1992年 | 5篇 |
1991年 | 5篇 |
1990年 | 8篇 |
1989年 | 3篇 |
1988年 | 8篇 |
1987年 | 2篇 |
1986年 | 2篇 |
1985年 | 4篇 |
1984年 | 1篇 |
1983年 | 3篇 |
1981年 | 1篇 |
1976年 | 2篇 |
排序方式: 共有1414条查询结果,搜索用时 11 毫秒
1.
2.
On the basis of earlier success in rat studies, chlorpromazine was evaluated as a probable agent for improving survival of random skin flaps in pigs. The aim was to exclude the possibility that the effect of the chlorpromazine is species specific and to find out if it is dose dependent. One hundred and five dorsally-based 12×4 cm flaps were raised unilaterally on the backs of 15 pigs. The animals were divided into three groups using 15 mg/kg chlorpromazine, 7.5 mg/kg chlorpromazine, and a saline-treated control group. Flaps in the control group averaged 40.57±3.17% necrosis, while flaps in the 15 mg/kg and 7.5 mg/kg chlorpromazine-treated groups averaged 31.53±4.77% and 11.47±2.22% necrosis respectively. These results demonstrate dose dependent beneficial affects of chlorpromazine and the survival of random skin flaps in the pig. Although ideal dose levels are still to be determined, flap survival improved with the prophylactic use of chlorpromazine at the lower 7.5 mg/kg dosage. 相似文献
3.
Comparison of positive allergy skin tests among asthmatic children from rural and urban areas living within small geographic area. 总被引:1,自引:0,他引:1
Haim Bibi David Shoseyov David Feigenbaum Pnina Nir Rosa Shiachi Shimon Scharff Ronit Peled 《Annals of allergy, asthma & immunology》2002,88(4):416-420
BACKGROUND: Evidence of increased asthma and allergic response among urban versus rural residents has been reported. OBJECTIVE: To evaluate the prevalence of allergic response among asthmatic children from urban and rural areas living within close proximity. METHODS: In all, 448 asthmatic children from urban (363) and rural (85) areas were studied. The study group consisted of 234 9-year-olds and 214 12-year-olds. A health questionnaire was completed on each child who subsequently underwent allergic skin prick tests (SPTs). RESULTS: There was significantly more positive SPT response to house-dust mite, mold, cat, and cypress among asthmatic children from urban areas compared with children living in rural areas: 58.3% versus 37.6%, 46.1% versus 31.8%, 17.45 versus 5.9%, and 26.2% versus 15.3%, respectively. Positive SPT for indoor allergens were significantly greater among asthmatic urban residents than asthmatic rural residents: 63.3% versus 45.5%, respectively (P < 0.02). Positive SPT response to all the allergens checked was higher among the 12-year-old age group when compared with the 9-year-olds, 34.6% versus 22.7%, respectively (P = 0.05). CONCLUSIONS: Allergic response measured by SPT is significantly more common among asthmatic children from urban areas as opposed to rural, even though both areas are within small distance of one another. Further, asthmatic children living in urban areas demonstrated more allergic response to both indoor and outdoor allergens. The allergic response tends to increase with increased age in both urban and rural asthmatic children. 相似文献
4.
Th1 cell development induced by cysteine proteinases A and B in localized cutaneous leishmaniasis due to Leishmania guyanensis
下载免费PDF全文
![点击此处可从《Infection and immunity》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Pascalis H Lavergne A Bourreau E Prévot-Linguet G Kariminia A Pradinaud R Rafati S Launois P 《Infection and immunity》2003,71(5):2924-2926
The cysteine proteinases CPA and CPB from Leishmania major induced Th1 responses in patients with leishmaniasis due to Leishmania guyanensis. Furthermore, cysteine proteinases induced neither interleukin 4 (IL-4) nor IL-13 and low levels of IL-10 in controls and patients. The results suggest that CPs would be quite good candidates for a vaccine against different Leishmania species. 相似文献
5.
Chakib Nejjari Abdelghafour Marfak Ahmed Rguig Abderrahmane Maaroufi Ihssane El Marouani Abderrafii El Haloui Bouchra El Johra Rachid Ouahabi Rachid Moulki Amina Idrissi Azami Youness El Achhab 《AIMS Public Health》2021,8(2):285
This study presents the relationships between ambient air pollutants and morbidity and emergency department visits among children and adults performed in Great Casablanca, the most populated and economic region in Morocco. This research was analyzed using conditional Poisson model for the period 2011–2013. In the period of study, the daily average concentrations of SO2, NO2, O3 and PM10 in Casablanca were 209.4 µg/m3, 61 µg/m3, 113.2 µg/m3 and 75.1 µg/m3, respectively. In children less than 5 years old, risk of asthma could be increased until 12% per 10 µg/m3 increase in NO2, PM10, SO2 and O3. In children over 5 years and adults, an increase of 10 µg/m3 air pollutant can cause an increase until 3% and 4% in respiratory consultations and acute respiratory infection, respectively. Similarly, impact on emergency department visits due to respiratory and cardiac illness was established. Our results suggest a not negligible impact on morbidity of outdoor air pollution by NO2, SO2, O3, and PM10. 相似文献
6.
Barghadouch Amina Norredam Marie 《Journal of immigrant and minority health / Center for Minority Public Health》2022,24(2):551-555
Journal of Immigrant and Minority Health - Much work has gone into unpacking the range of individual, interpersonal and structural barriers that prevent asylum-seekers from accessing healthcare. In... 相似文献
7.
Sahar rajabzadeh Karizi Fatemeh Armanmehr Hamideh Ghodrati Azadi Hojjat Shadman Zahroodi AmirAli Moodi Ghalibaf Bibi Sedigheh Fazly Bazzaz Mohammadreza Abbaspour Javad Boskabadi Saeid Eslami Zhila Taherzadeh 《Phytotherapy research : PTR》2023,37(4):1435-1448
The efficacy of spirulina platensis (S. platensis) as an add-on therapy to metformin and its effect on atherogenic keys in patients with uncontrolled Type 2 Diabetes Mellitus (T2DM) was evaluated. Sixty patients were randomly assigned to S. platensis (2 g/day) or placebo group for three months while continuing metformin as their usual treatment. The efficacy of S. platensis was determined using the pre- and post-intervention HbA1c levels (primary outcome) as well as tracking FBS and lipid profiles levels (TC, LDL-C, TG, and HDL-C) as secondary outcomes at the different treatment time points (0,30,60,90 days). During the three–month intervention period, supplementation with S. platensis resulted in a significant lowering of HbA1c (↓1.43, p < 0.001) and FBS (↓ 24.94 mg/dL, p < 001) levels. Mean TG in the intervention group was found to be significantly lower in the intervention group than in controls (p < 0.001). Total cholesterol (TC) and its fraction, LDL-C, exhibited a fall (↓41.36 mg/dL and ↓38.4 mg/dL, respectively; p < 0.001) coupled with a marginal increase in the level of HDL-C (↑3 mg/dL; p < 0.001). Add-on therapy with S. platensis was superior to metformin regarding long-term glucose regulation and controlling blood glucose levels of subjects with T2DM. Also, as a functional supplement, S. platensis has a beneficial effect on atherogenic keys (TG and HDL-C) with no adverse events. 相似文献
8.
Mostafa Kamalpour Atae Rezaei Aghdam Jason Watson Amina Tariq Laurie Buys Rebekah Eden Syed Rehan 《Health & social care in the community》2021,29(2):328-343
The aim of this paper is twofold. Firstly, to investigate the potential benefits of online health communities (OHCs) for informal caregivers by conducting a systematic literature review. Secondly, to identify the relationship between the potential benefits of OHCs and resilience factors of older adults. Performing a thematic analysis, we identified the potential benefits of OHCs for informal caregivers of older adults, including two salient themes: (a) caregivers sharing and receiving social support and (b) self and moral empowerment of caregivers. Then, we uncovered how these potential benefits can support resilience of older adults. Our findings show that sharing and receiving of social support by informal caregivers, and self and moral empowerment of informal caregivers in OHCs, can support four resilience factors among older adults, including self-care, independence, altruism and external connections. This review enables a better understanding of OHCs and Gerontology, and our outcomes also challenge the way healthcare and aged-care service providers view caregivers and older adults. Furthermore, the identified gap and opportunities would provide avenues for further research in OHCs. 相似文献
9.
Rakhadilov Bauyrzhan Pogrebnjak Alexander Sagdoldina Zhuldyz Buitkenov Dastan Beresnev Vyacheslav Amina Mukhamedova 《Materials》2022,15(21)
This work is devoted to the study of the formation of nanostructured multilayer coatings (TiZr/Nb)N on the surface of an AISI 321 steel substrate depending on the deposition parameters of the Arc-PVD method. The results of the X-ray diffraction analysis showed the formation of solid solution (TiNb)N and ZrN in the multilayer coatings with an FCC structure, ε-NbN with a hexagonal structure, as well as with a small volume fraction of the ε-Ti2N and β-Nb2N phase. On the basis of phase composition data, it is possible to assume that an increase in the number of bilayers leads to a decrease in the nitrogen concentration in the bilayers and, consequently, to a decrease in the volume fraction of ε-NbN and β-Nb2N nitrides. In all investigated systems obtained at −100 V and −200 V bias potentials, ε-NbN is the main phase. The study of the element distribution over the thickness of the (TiZr/Nb)N coating confirms the results of the X-ray diffraction analysis. The use of the structure model in the form of alternating layers allows for significantly improving the adhesion characteristics of the protective coating, as well as ensuring their high hardness. Based on the experimental results, it is possible to analyze changes in the mechanical and tribological properties of multilayer coatings depending on the number of applied bilayers. The results of the study of the elastic modulus and hardness of multilayer coatings (TiZrNb)N with different numbers of bilayers showed that a large number of bilayers (small thickness of each individual layer) shows the lowest value of hardness. It is assumed that as the bilayer thickness decreases, the coating characteristics are closer to the monolayer alloy than to the multilayer structure. 相似文献
10.
A phase 1 study of the CXCR4 antagonist plerixafor in combination with high‐dose cytarabine and etoposide in children with relapsed or refractory acute leukemias or myelodysplastic syndrome: A Pediatric Oncology Experimental Therapeutics Investigators’ Consortium study (POE 10‐03)
下载免费PDF全文
![点击此处可从《Pediatric blood & cancer》网站下载免费的PDF全文](/ch/ext_images/free.gif)