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Aisia Azus Hsiang-Ling Teng Lauren Tufts Daniel Wu C. Benjamin Ma Richard B. Souza Xiaojuan Li 《PM & R》2018,10(1):56-63
Background
Few studies have investigated the associations between patient-reported outcome and gait in patients with anterior cruciate ligament (ACL) injury and reconstruction over time. Because there is an association between ACL rupture and the presence of osteoarthritis later in life, a better understanding of these relationships will help to elucidate how patients’ gait pattern may affect pain and symptoms, potentially leading to better treatment for or preventing the development of knee OA.Objective
To evaluate the associations between gait characteristics and self-reported pain and symptoms before, 6 months after, and 1 year after anterior cruciate ligament reconstruction.Design
Prospective cohort study.Setting
The Human Performance Center at the Orthopedic Institute at the University of California, San Francisco.Patients
Patients with full unilateral ACL tears were enrolled. A total of 43 patients were included at 12 months postsurgery.Methods
The independent variable in this study comprised specific gait variables in patients who had undergone ACL reconstruction. At each time point, 3-dimensional motion analysis was performed. Participants also completed the Knee Osteoarthritis Outcome Score (KOOS) questionnaire.Main Outcomes Measurements
The primary study outcome measurement was the KOOS and was planned before data collection began. Partial correlations were used to examine cross-sectional associations between gait characteristics and KOOS pain and symptom scores at all time points. In addition, partial correlations were performed to examine the associations between change in postoperative KOOS from 6 months to 1 year and gait characteristics at baseline and 6 months.Results
Significant associations between KOOS and gait characteristics were found at all time points, including an association between peak medial ground reaction force and pain (r = ?0.344, P = .02) and symptoms (r = ?0.407, P = .007) at baseline.Conclusions
Specific gait variables may be predictive of greater pain and symptoms and less improvement over time postreconstruction. This could help to inform rehabilitation exercises post injury and pre reconstruction.Level of Evidence
IV 相似文献2.
Sabine Oskar Natalie J. Engmann Aisia R. Azus Parisa Tehranifar 《Cancer causes & control : CCC》2018,29(8):731-736
Purpose
Type II diabetes mellitus (T2DM) has consistently been associated with an increased risk of breast cancer, but the association of gestational diabetes mellitus (GDM) with breast cancer is less clear. T2DM and GDM may influence breast cancer risk through mammographic breast density, a strong risk factor for breast cancer. We examined whether T2DM and GDM are associated with higher mammographic breast density in a largely racial/ethnic minority sample.Methods
We collected digital mammograms, anthropometric measures, and interview data from 511 racially diverse women recruited during screening mammography appointments between 2012 and 2016 (mean age 51 years; 70% Hispanic). We examined the associations of self-reported GDM, T2DM, and medication use (metformin and insulin) with mammographic breast density, measured as percent and area of dense tissue using Cumulus software.Results
In multivariable linear regression models, history of T2DM and/or GDM and length of time since diagnosis were not associated with percent density or dense breast area, either before or after adjustment for current BMI. Use of metformin in diabetic women was associated with lower percent density (β?=???5.73, 95% CI ??10.27, ??1.19), only before adjusting for BMI. These associations were not modified by menopausal status.Conclusions
Our results do not support associations between T2DM and/or GDM and higher amount of mammographically dense breast tissue, suggesting that the mechanism linking diabetes with breast cancer risk may not include mammographic breast density in midlife.3.
J E Sheedy M Buri I L Bailey J Azus I M Borish 《American journal of optometry and physiological optics》1987,64(2):90-99
The optical characteristics of the major progressive addition lenses were measured using an automated lensometer with a specially designed lens holder to simulate eye rotation. Measurements were made every 3 degrees (about 1.5 mm) and graphs of isospherical equivalent lines and isocylinder lines were developed. Generally the near zone of these lenses is narrower and lower than in bifocal or trifocal lenses. Distinct differences exist between the various progressive lenses. The width of the near zone, rate of power progression, amount of unwanted cylinder (level with the distance center), and clarity of the distance zone are compared for the various lenses. The optical measurements demonstrate an apparent trade-off between the size of the cylinder-free area of the lens and the amount of the cylinder. 相似文献
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