全文获取类型
收费全文 | 2913篇 |
免费 | 230篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 32篇 |
儿科学 | 138篇 |
妇产科学 | 69篇 |
基础医学 | 370篇 |
口腔科学 | 106篇 |
临床医学 | 286篇 |
内科学 | 770篇 |
皮肤病学 | 60篇 |
神经病学 | 229篇 |
特种医学 | 169篇 |
外科学 | 294篇 |
综合类 | 57篇 |
一般理论 | 2篇 |
预防医学 | 213篇 |
眼科学 | 22篇 |
药学 | 177篇 |
中国医学 | 9篇 |
肿瘤学 | 157篇 |
出版年
2023年 | 12篇 |
2022年 | 24篇 |
2021年 | 87篇 |
2020年 | 42篇 |
2019年 | 88篇 |
2018年 | 76篇 |
2017年 | 65篇 |
2016年 | 68篇 |
2015年 | 82篇 |
2014年 | 103篇 |
2013年 | 118篇 |
2012年 | 138篇 |
2011年 | 135篇 |
2010年 | 116篇 |
2009年 | 98篇 |
2008年 | 141篇 |
2007年 | 141篇 |
2006年 | 118篇 |
2005年 | 133篇 |
2004年 | 120篇 |
2003年 | 109篇 |
2002年 | 90篇 |
2001年 | 80篇 |
2000年 | 103篇 |
1999年 | 96篇 |
1998年 | 74篇 |
1997年 | 56篇 |
1996年 | 54篇 |
1995年 | 38篇 |
1994年 | 44篇 |
1993年 | 38篇 |
1992年 | 42篇 |
1991年 | 32篇 |
1990年 | 30篇 |
1989年 | 34篇 |
1988年 | 31篇 |
1987年 | 27篇 |
1986年 | 27篇 |
1985年 | 30篇 |
1984年 | 17篇 |
1983年 | 18篇 |
1982年 | 19篇 |
1981年 | 16篇 |
1980年 | 15篇 |
1979年 | 19篇 |
1977年 | 17篇 |
1976年 | 13篇 |
1975年 | 15篇 |
1974年 | 8篇 |
1970年 | 12篇 |
排序方式: 共有3160条查询结果,搜索用时 170 毫秒
1.
A. Guerrero Gómez N. González Jaramillo J.A. Castro Pérez 《Revista espa?ola de anestesiología y reanimación》2019,66(1):10-17
Introduction
The fast track / ultra-fast-track protocols are techniques used to optimise the patient care process and a quick recovery after cardiac surgery. They are one of the mainstays of efficient practice. With their use, the length of hospital and intensive care unit (ICU) stays are reduced, with a direct impact on costs and the quality of the health service.Objective
To compare the length of stay in the ICU, length of hospital stay, and post-operative mortality in ultra-fast-track extubated (uFTE) patients and those with conventional extubation (CE) after cardiac surgery.Methods
Longitudinal, analytical, retrospective study was conducted, with the period between the time of surgery and discharge being included as the study period.Results
A total of 396 patients older than 18 years who required cardiac surgery were included, of whom 207 patients had (uFTE) and 189 had CE. Although the groups were not comparable due to the statistical differences found, when performing the multivariate adjustment, uFTE maintained its statistical independence and was associated with lower cardiovascular morbidity, such as myocardial ischaemia (95% CI: 0.37-0.86; P = .01) and lower post-surgical vasopressor requirement (95% CI: 0.18-0.49; P < .01). No significant differences were found in the length of hospital stay, ICU stay, or post-operative mortality in the ICU.Conclusion
Implementing the uFTE strategy, decreases cardiovascular morbidity and vasopressor requirement. The change to uFTE should be accompanied by changes in models and practices in patient recovery to standardised protocols. This study shows that uFTE did not reduce the length of ICU stay, hospital stay, or mortality. 相似文献2.
3.
Abstract Caries experience and enamel fluorosis prevalence in 8-year-old children belonging to different socio-economic classes were determined in two Chilean twin cities that are served by optimally fluoridated community water from the same waterworks facility. Low socio-economic status (LSES) children had a higher mean dm ft and DMFT indices (P<0.001) than high socioeconomic status (HSES) children. Prevalence of enamel fluorosis in the permanent teeth of LSES children was 0.79, significantly higher (X2= 9.0; P<0.003) than the value 0.59 found in HSES children. The proportion of Dean's scores 2. 3, 4 and 5 in first molars, mandibular and maxillary incisors in LSES children was higher than in HSES children (P<0.001). Differences in prevalence and seventy of enamel fluorosis between both groups are tentatively attributed lo a different pattern of tap water and tea consumption at pre-school ages. Suggestions are advanced to minimize the undesirable prevalence and severity of enamel fluorosis. 相似文献
4.
5.
急性心肌梗死患者出现束支传导阻滞(BBB)被认为与预后差有关。这种观点在血管成形术时代是否正确尚不清楚。本研究旨在评估采用直接血管成形术治疗的急性心肌梗死伴BBB患者的预后。评估了急性心肌梗死直接血管成形术试验中3053例接受急诊导管术的患者。将入院心电图存在左束支传导阻滞的患者(LBBB,n=48,1.6%)与右束支传导阻滞患者(RBBB,n=95,3.1%)或无BBB患者(n=2910,95.3%)进行比较。具有BBB的患者年龄较大,更多见糖尿病、外周血管疾病和曾行冠状动脉搭桥术,射血分数较低,多支血管病变多见。 相似文献
6.
Ilham Bettahi David Pozo Carmen Osuna Russel J. Reiter Dario Acuña-Castroviejo Juan M. Guerrero 《Journal of pineal research》1996,20(4):205-210
Abstract: In this report, rat hypothalamic nitric oxide synthase (NOS) activity is shown to be partially inhibited by physiological concentrations of the pineal hormone melatonin. In vitro studies demonstrate that 1 nM melatonin, which approximates the physiological concentration of the hormone at night, significantly inhibited NOS activity. In vivo studies show that administering melatonin or collecting the hypothalamus from animals at night, when endogenous melatonin levels are elevated, results in a significant decrease of NOS activity. Results also show that calmodulin may be involved in this process since its presence in the incubation medium prevents the inhibitory effect of melatonin on NOS activity. 相似文献
7.
S de Sanjosé M Santamaria P Alonso de Ruiz N Aristizabal E Guerrero X Castellsagué F X Bosch 《IARC scientific publications》1992,(119):75-84
PCR-based hybridization methods have been used to show that some women with normal cytology are carriers of HPV DNA of the types strongly related to cervical cancer. How these women should be managed remains unclear. This chapter selectively reviews reports which have estimated type-specific HPV prevalence in relation to the presence or absence of morphological signs of HPV infection. Overall, these reports indicate that among women who were identified as carriers of HPV DNA (by PCR-based methods) and who also had a normal cytological smear, the HPV type detected in the majority of instances was a high-risk viral type for cervical cancer (HPV types 16/18 = 44.7%; HPV types 31/33/35 = 8.1%; other and unknown types = 37.9%). This suggests that screening programmes which include PCR-based HPV detection could reduce the false negative rates currently reported by screening programmes based on cytology alone. 相似文献
8.
GP SCHWAB AL BLUM E BODNER B DALLEMAGNE K GLASER H KOOP F PACE W RÖSCH JR SIEWERT G WETSCHER 《Journal of gastroenterology and hepatology》1997,12(12):785-789
Gastroesophageal reflux disease (GERD) is the most common disease of the upper gastrointestinal tract. With the introduction of proton pump inhibitors medical treatment of GERD has been significantly improved. However, the development of laparoscopic antireflux surgery resulted in an increasing interest of surgeons in this disease. An interactive meeting was organized in order to develop an agreement between gastoenterologists and surgeons regarding therapeutic decisions and this is the main topic of this paper. 相似文献
9.
Sara Lucena Belsy Guerrero Ana M Salazar Amparo Gil Carmen L Arocha-Pi?ango 《Blood coagulation & fibrinolysis》2006,17(6):427-435
Lonomia achelous is a caterpillar distributed in southern Venezuela and in northern Brazil that causes an acute hemorrhagic syndrome in people who have contact with its bristles. The effect of the crude hemolymph and its chromatographic fractions (FDII, Lonomin V and Lonomin V-2) on extracellular matrix proteins was studied. The chromatographic fractions show activities similar to plasmin and urokinase. In sodium dodecyl sulfate-polyacrylamide gel electrophoresis, both lonomins appear as a protein band of 25 kDa under reduced conditions. By exclusion chromatography, the molecular weights of Lonomin V and Lonomin V-2 were 26.5 and 24.5 kDa, respectively. Fibronectin, laminin and vitronectin were degraded by all venom components. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis, under reduced conditions, shows that lonomins degrade fibronectin in four main fragments of 116, 60, 50 and 30 kDa. Molecular exclusion chromatography in native conditions shows that the molecular masses of these fragments are > or = 300, 62 and 27 kDa. The proteolytic effect of lonomins was abolished by benzamidine/HCl, iodoacetic acid and aprotinin. The extracellular matrix protein degradation together with the fibrino(geno)lytic activity of hemolymph and its fractions could explain, in part, the hemorrhagic syndrome, and the wound dehiscence in persons who have had contact with the L. achelous caterpillar. 相似文献
10.
M Guerrero Fernández J L Alfonso Sánchez B Sanchís Noguera M J Prado del Ba?o 《Gaceta sanitaria / S.E.S.P.A.S》1992,6(29):62-66
Data are presented on hospital stay for the population 65 years-old and over, measured in percentage over the total for Spain, for the 1978 to 1988 period, by gender, for each province and autonomous region (Comunidad Autónoma). The country's total for the last available year was 35%. Except in Baleares and Murcia, the proportion of hospital stays increased in all Regions, especially in Navarra, where it increased from 23% to 51%. After adjusting for age, the increase in the proportion of hospital stays in the study population was due to an increase in utilization per person. The proportion, which was 13.3% in 1978, raised to 23.8% in 1988, with an adjusted value of 21.3%. 相似文献