心室肌脂肪:一个意想不到的远期生存生物标志物?

正目的非增强CT常常观察到心肌脂肪,但对其认识不足,本文旨在探究心肌内脂肪与全因死亡率的关系,无论是否有心肌梗死病史。方法本回顾性队列研究收集了不     

Simultaneous Determination of Six Compounds in Rat Plasma by Ultra‑Performance Liquid Chromatography with Tandem Mass Spectrometry: Application in the Pharmacokinetic Study of Qing Gan‑Shu Yu‑Fang

A rapid and high selective ultra?performance liquid chromatography (UPLC) with tandem mass spectrometry method for simultaneous determination of six compounds including albiflorin, paeoniflorin, picroside I, picroside II, saikosaponin A, and saikosaponin D in rat plasma was developed and validated using butyl p-hydroxybenzoate as an internal standard. One-step direct protein precipitation with acetonitrile was used to extract the compounds from the rat plasma samples. Chromatographic separation was achieved using an ACQUITY UPLC BEH C18 column (100 mm × 2.1 mm, 1.7 µm) at a flow rate of 0.4 mL/min, using gradient mode containing 0.1% formic acid in water and acetonitrile were used as the Mobile phase A and B. Electrospray ionization in negative ion mode and multiple reaction monitoring were used to identify and quantify active components. Calibration curves showed good linearity (R2 > 0.9908) over a wide concentration range for all compounds. The intra- and interday precision (relative standard deviation) ranged 2.4%–7.0% and 2.6%–8.0%, respectively. The accuracy (relative error) was from ?13.0% to 13.2% at all quality control levels. The recovery ranged from 81.1% to 92.5%. The validated method was successfully applied to pharmacokinetic study in rats after oral administration of Qing Gan?Shu Yu?Fang. The results show that one can draw a conclusion that these six active ingredients can be quickly absorbed and play a pharmacodynamic role rapidly in vivo.     

严重性血友病性骨关节病1例报道与文献回顾

正1临床资料患者,男性,40岁,60kg,13岁时确诊为A型血友病。因"反复多发关节肿痛27年加重伴行走困难4年"入院。患者于13岁时无明显诱因出现双膝关节肿痛,就诊于当地医院行相关检查后诊断为"A型血友病",给予补充凝血Ⅷ因子制剂,症状明显好转。此后全身多处关节反复出现肿痛,以     

软组织肉瘤:与组织学分级和病人预后相关的MRI特征评估

正摘要软组织肉瘤的治疗依赖于组织学分级,这是最重要的预后因素和活检后常规评估。然而,由于肿瘤的异质性,组织学分级可能会被低估。目的确定与高级别软组织肉瘤     

眼球运动核综合征患者发生海绵状血管瘤报道1例

前言:眼神经的眼运动核综合征首次报道于1981年,其特征是同侧的第Ⅲ脑神经麻痹和对侧眼的高度麻痹。病例报道:1例59岁的男性患者突发复视与头痛。神经系统检查表明:左侧第Ⅲ脑神经存在核性眼肌麻痹,同时无任何其它神经检查的异常。M RI检查发现了1处典型的、爆米花样、平滑的左     

Percutaneous endoluminal grafts for AAA repair in the catheterization laboratory

Background Percutaneous abdominal aortic aneurysm(AAA) repair has been previously described using the "preclose"technique and general endotrachial anesthesia (GA).     

1996—2001年在家实施胃肠外营养的调查研究

目的:自1970年以来,丹麦就开始对肠衰竭患者推行在家实施胃肠外营养(H PN)。该研究设计为一个数据来源可靠的系列化队列研究,回顾性调查了1996—2000年底丹麦全国的H PN患者资料,包括发病率、患病率、患者特征和H PN治疗的并发症等。材料与方法:选取接受H PN治疗的患者202例(女性115例,男性87例),其中34%为炎症性肠病导致的短肠综合征,26%为癌症患者,22%为外科手术并发症,19%为其他原因,共使用410(导管·年)。结果:截止2000年底,全丹麦H PN流行率为19.2/106人,平均发生率为5.0/106(人·年),与导管相关的菌血症和血栓发生率分别为0.48/…     

伴Leiden V因子突变和狼疮抗凝物的恶性萎缩性丘疹病（Degos病）死亡1例

恶性萎缩性丘疹病（Degos病）是一类非常罕见的疾病，其皮损特点是萎缩性丘疹和多种系统症状。作者描述了1例33岁的男性患者，其表现为泛发性皮损，与恶性萎缩性丘疹病的体征一致。患者病程中甚至发生阴茎溃疡，此症状以往仅有少数报道。患者发病2．5年后死于小肠复穿孔。实验室检查显示Leide nV因子突变和狼疮抗凝物的出现，但未发现抗心肌磷脂抗体。患者先后接受了窄波紫外线（UV）、强的松龙和阿司匹林、己酮可可碱、华法林的治疗。尽管接受了这种强抗凝血和抗血小板治疗，患者皮损和系统症状仍未得到改善。     

应用二甲双胍长期及短期治疗调节多囊卵巢综合征妇女的月经周期效果

本回顾性研究旨在比较两组多囊卵巢综合征患者的月经周期频率:应用二甲双胍治疗3～6个月及>6个月的妇女。结果显示二甲双胍在调节多囊卵巢综合征妇女的月经周期正常方面疗效显著(全部反应率为69%,获得正常周期者反应率为88%),在治疗持续6个月或更长的患者中疗效更显著(二甲双胍