The Releasing Effects of Captopril and Sodiun Nitroprusside on Endothelin-1 in Vascular Smooth Muscle Cell

Objective To investigate the influence of captoprial and SNP on the release of ET -1 in cultured VSMC of rats. Methods Measurement of endothelin - 1 levels by radioimmljnoassay in various concentrations of captopril and/or sodium nitroprusside in cultured vascular smooth muscle cell (VSMC) of rats. Results Both captopril and SNP could reduce the high ET - 1 levels of VSMC which were caused by Ang Ⅱ. There was a linear relationship between Ang Ⅱlevels and ET -1 production ( r = 0. 760, P <0. 001 ) . Conclusion Endothelin - 1 may accelerate the formation and development of atherosclerosis through inhibiting endogenous NO production by VSMC. ACEI or NO inhibition of ET -1 release could reduce atherosclerosis formation.     

卡托普利及SNP对VSMC中ET—1释放的作用

目的探讨卡托普利及ＳＮＰ对培养的大鼠ＶＳＭＣ释放ＥＴ－１的影响及相互关系。方法在大鼠ＶＳＭＣ培养液中置入不同浓度卡托普利及／或ＳＮＰ后,用放免法测定ＥＴ－１。结果卡托普利及ＳＮＰ均可减低因ＡｎｇⅡ引起ＶＳＭＣ分泌增加的内皮素量,ＡｎｇⅡ水平与ＶＳＭＣ分泌ＥＴ－１量呈正相关。结论ＥＴ－１通过抑制ＶＳＭＣ内源性ＮＯ的产生加速ＡＳ的发生及发展,ＡＣＥＩ或ＮＯ抑制ＥＴ－１释放,可减缓ＡＳ形成。     

米非司酮配伍米索前列醇在中期引产中的应用

本探讨小剂量米非司酮配伍米索前列醇阴道后穹隆放药用于中期引产的可行性。３２例采用此方法，３２例利凡诺羊膜腔内注射引产作对比。从宫缩至胎儿、胎盘娩出，米索组（５．１２小时±２．５２小时）明显少于利凡诺组（８．３０±４．０５小时）；引产平均出血量，米索组（７５．６３±３７．９１ｍｌ）明显少于利凡诺组（１５２．３４±４０．５１ｍｌ）；胎盘、胎膜滞留及清宫，米索组（１２．５％）明显低于利凡诺组（６２．５％）；结果表明：小剂量米非司酮口服配伍阴道后穹隆放入米索前列醇进行中期引产效果明显优于利凡诺引产。