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目的分析甲流疫苗接种后不良反应的发生情况。方法对阅兵村2009年9月10—15日接种甲流疫苗的1 150名阅兵保障人员进行调查,对不良反应发生率、不良反应出现及持续时间、转归等进行分析。结果 18名接种者发生不良反应,总反应率1.6%(18/1 150),其中局部不良反应发生率为1.1%(13/1 150),全身不良反应发生率为0.4%(5/1150),所有发生不良反应者经1~5 d均能自愈或治愈。结论甲流疫苗接种后不良反应发生率低,以局部轻型不良反应为主,持续时间短,无严重不良反应,适宜无接种禁忌症人群的普遍接种。 相似文献
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单核/巨噬细胞释放的趋化性细胞因子与急性肺损伤 总被引:11,自引:0,他引:11
金敬顺 《国外医学:呼吸系统分册》1997,17(3):133-136
本概述单核/巨噬细胞有关的趋化性因子的分类和来源,重点介绍几种主要的趋化性细胞因子,如白介素-8、巨噬细胞炎症蛋白和单核细胞趋化蛋白等的基因和蛋白质结构及在急性肺损伤中的作用。 相似文献
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脂多糖致肺血管内巨噬细胞分泌功能的改变 总被引:1,自引:0,他引:1
目的 探讨肺血管内巨噬细胞(PIM)在感染性急性肺损伤(ALI)发病中的作用.方法 采用改良Morton法分离、培养猪PIM;用贴壁法获得黏附的PIM,培养于RPMI 1640培养基,予10 mg/L脂多糖(LPS)刺激.用鼠胸腺细胞增殖法测定白细胞介素-1β(IL-1β)活性,酶联免疫吸附法(ELISA)测定IL-6、IL-8含量.结果 LPS刺激后,PIM释放IL-1β、IL-6和IL-8均增多,峰值分别出现在刺激后的2 h[IL-1β活性(10 400±2 389)次/min]、4 h[IL-6含量(0.80±0.36)μg/L]和6 h[IL-8含量(4.94±1.19)μg/L],与刺激前[IL-1β活性(213±85)次/min,IL-6含量(0.27±0.12)μg/L,IL-8含量(1.84±0.53)μg/L]比较差异均有统计学意义(均P<0.01).结论 LPS刺激后,PIM分泌多种细胞因子,其中IL-1β升高最早,提示其在ALI发病早期起重要作用;而IL-6、IL-8升高较晚,且持续时间较长,可能对ALI的病情进展起重要作用.细胞因子间的相互作用在ALI的发病中似乎更为重要.Abstract: Objective To investigate the role of pulmonary intravascular macrophages(PIMs)in the pathogenesis of acute lung injury(ALI)due to infection. Methods Porcine pulmonary blood vessels were flushed by modified Morton method, and PIMs were isolated and cultured. The adhered PIMs were collected with adhesion method and incubated in RPMI 1640 medium. They were challenged with lipopolysaccharide (LPS, 10 mg/L). The activity of interleukin-1β(IL-1β), and contents of IL-6 and IL-8 in the culture supernatant were measured by method of thymocyte proliferation and enzyme linked immunoadsorbent assay (ELISA). Results The released contents of IL-1β, IL-6 and IL-8 from PIMs were increased significantly compared with those before LPS challenge, and they peaked at 2 hours[IL-1β activity:(10 400±2 389)scintillant count/min], 4 hours[IL-6 content:(0. 80± 0. 36)μg/L], and 6 hours[IL-8 content:(4. 94± 1.19)μg/L]after LPS challenge, and the differences were significant compared with those before LPS challenge[IL-1β activity:(213±85)scintillant count/min, IL-6 content:(0. 27 ± 0. 12)μg/L, IL-8 content:(1.84±0.53)μg/L, all P<0. 01]. Conclusion Among the cytokines released from PIMs after LPS challenge, the increase in IL-1β occurred earlier in comparison with that of IL-6 and IL-8, suggesting that the former might play an important role at the early stage of ALI; on the other hand, though the increase in IL-6 and IL-8 contents occurred later than that of IL-1β but it lasted for a longer duration,suggesting that they might be associated with the advancement of ALI. The results also suggested that interaction of these cytokines played a more important role in the pathogenesis of ALI. 相似文献
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脂多糖致肺血管内巨噬细胞释放几种细胞因子的改变 总被引:1,自引:0,他引:1
目的 探讨肺血管内巨噬细胞(PIM)释放的细胞因子在感染性急性肺损伤(ALI)发病中的作用。方法 仿Morton法灌洗肺血管床,贴壁法分离猪PIM,培养于PIM1640培养基,予10μg/ml脂多糖(LPS)刺激,胸腺细胞增殖法测PIM培养上清白细胞介素1β(IL-1β)活性,酶联免疫吸附试验(ELISA)法测肿瘤坏死因子α(TNFα)、白细胞介素6(IL-6)、白细胞介素8(IL-8)含量。结果 相似文献
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凋亡抑制蛋白Livin在肿瘤治疗中的新进展 总被引:1,自引:0,他引:1
Livin是凋亡抑制蛋白的一个新成员,可以编码抑制凋亡的负性调节蛋白.Livin在大多数肿瘤中高表达,体内外研究发现其表达降低可以增加肿瘤细胞凋亡,降低肿瘤细胞的生长潜能,增加肿瘤细胞对化疗的敏感性.因此,Livin可以作为肿瘤治疗的新的靶点. 相似文献
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目的 探讨肺血管内巨噬细胞(PIM)释放的细胞因子在感染性急性肺损伤(ALI)发病中的作用。方法 仿Morton法灌洗肺血管床,贴壁法分离猪PIM,培养RPMI-1640培养基,予10mg/L脂多糖(LPS)刺激,胸腺细胞增生法测PIM培养液上清白细胞介素-1β(IL-1β)活性,酶联免疫吸附试验(ELISA)测肿瘤坏死因子α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)含 相似文献