携载rhBMP-2微球的新型可注射自凝固复合人工骨的制备及特性研究

[目的]制备一种具有良好降解性和成骨活性、可注射的自凝固新型骨修复材料。[方法]制备携载rhBMP-2的聚乳酸与聚乙醇酸共聚物（PLGA）微球，并将其与rhBMP-2／磷酸钙骨水泥（CPC）复合，制备出rhBMP-2／PLGA微球／CPC复合人工骨。探讨了材料的特性，包括形貌、固化时间、抗压强度及反映材料体外降解速度的指标一体外降解液Ca、P浓度变化，测定复合材料rhBMP乏的释药速度及体外诱导MSCs细胞成骨分化的能力。[结果]与单纯CPC-rhBMP-2相比，复合材料的固化时间少量增加，抗压强度下降明显。体外降解速度及体外释药明显提高，释放的rhBMP-2具有骨诱导活性。[结论]rhBMP-2／PLGA微球／磷酸钙骨水泥新型复合人工骨是具有良好应用前景的骨修复材料。     

护理教育课程设置的思考

在科学技术日益发展和社会进步的今天,结合临床护理工作中临床护士的知识结构和教育背景,探讨当今护士急需掌握的知识,以便在护理教育过程中对课程设置的内容进行相应改革,以适应日益发展的社会需要.     

活体肾移植和尸体肾移植术后疗效和安全性比较

近年来随着尸体供肾的日益短缺,国内活体肾移植例数迅速增加,但活体肾移植术后疗效和安全性尚有待进一步探讨.本研究回顾分析我院过去4年多来肾移植资料,比较两组患者术后长期疗效和安全性差异.     

Changes of Unit Discharge of the Medullary Respiratory Neurons during Apnea

Changes of the neuronal discharge of 128 medullary respiratory unitswere recorded and studied during the period of expiratory apnea induced reflexlyby intracarotid sinus injection of sodium citrate in rabbits.Generally,theneuronal discharge of inspiratory units began,stopped and recovered at the sametime with those of the phrenic nerve.But,about 5% the phase-spanninginspiratory units near the obex showed a different time course with the dischargeof the phrenic nerve.They fired continuously in a low frequency while thephrenic nerve was quiet.When increasing progressively and approaching to acertain level,the firing rate increased abruptly and at the same time phrenic nervebegan to fire.So it seemed that they acted as the pacemaker of inspiration.Comparison of the cycle-triggered histograms(CTH)of these inspiratory unitswith those of phrenic nerve showed clearly the above mentioned phasicrelationship.They started firing before the phrenic nerve,but they reached theirmaximal rate and then declined and stopped quite in accordance with the phrenicnerve.It is,therefore,reasonable to assume that the central mechanism of theswitch from expiratory apnea to inspiration may originate from this kind ofneurons.Most of the expiratory units show tonic discharges during the period of apneawith a higher discharge rate than normal and then the rate decreases just beforerecovery of phrenic firing.In addition,small portion of the expiratory units weredepressed as the phrenic discharge ceased.The function of these two differentkinds of neurons in the mechanism of development of respiratory rhythm is,apparently,different.     

应用阴离子间隙判断混合性酸碱失衡

应用阴离子间隙判断混合性酸碱失衡陈绍平邓淑琼李中海（川北医学院附属医院内科）（南部县人民医院内科）近年来，随着对慢性呼吸衰竭酸碱失衡认识的不断深化，多重性酸碱失衡类型的不断增多，原有的根据各种酸碱类型的图表及代偿预计公式来判定血气分析结果的方法已不能...     

醒脑开窍针法促进糖尿病合并脑梗死患者神经功能恢复

采用醒脑开窍针刺法治疗糖尿病脑梗死32例并与西药常规治疗28例对照比较,结果提示醒脑开窍针刺法能有效促进糖尿病脑梗死患者神经功能恢复。     

55例膝关节纤维性僵直的体疗效果

５５例膝关节纤维性僵直的体疗效果安徽医科大学附属医院康复运动医学科（合肥２３００２２）祁信立，赵凯，傅建华，费金水北京医科大学人民医院康复科江海燕膝关节伤病及任何使膝关节长期制动的因素都可能导致膝关书的僵直和功能障碍。本文对我院从１９８３年到１９９４...     

气滞胃痛颗粒剂治疗慢性胃炎46例

笔者从2000年～2003年6月用气滞胃痛颗粒剂治疗以胃脘部胀痛为主要表现的慢性胃炎,疗效较好,报道如下.     

肝外伤60例治疗体会

目的：探讨肝外伤治疗方法的合理选择．方法：回顾分析60例肝外伤的临床资料．结果：60例中非手术治疗6例，手术治疗54例，34例单纯肝缝合术，10例大网膜堵塞附加缝合术，全部治愈，纱布填塞术6例，3例治愈，3例死亡，切除性扩创术4例，2例治愈，2例死亡。结论：采用合理适当的手术治疗方法，可以提高肝外伤救治成功率。