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慢性肾小球肾炎尿毒症期血小板活化因子及肿瘤坏死因子α检测及临床意义 总被引:1,自引:0,他引:1
目的 探讨慢性肾小球肾炎尿毒症期患者血小板活化因子 (PAF)及肿瘤坏死因子α(TNF α)变化及意义。方法 采用生物活性法及双抗体酶联免疫吸附法 ,测定 14例慢性肾小球肾炎尿毒症期患者血浆PAF及血清TNF α水平。结果 慢性肾小球肾炎尿毒症期患者PAF及TNF α水平较正常对照组明显增高 ,差异有显著性 (P <0 .0 1) ,患者PAF及TNF α含量与尿素氮肌酐含量无明显相关性。结论 PAF与TNF α不仅参与了肾小球肾炎的发生 ,也可能持续参与了该病炎症的发展。二者之间的协同作用 ,加重了肾组织的广泛损伤 ,并影响到肾功能 ,PAF及TNF α水平与肾功能之间的关系有待进一步探讨 相似文献
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银杏叶提取物对肾毒血清性肾炎血小板活化因子水平的影响 总被引:9,自引:2,他引:7
目的:探讨银杏叶提取物对肾毒血清性肾炎(Masugi肾炎)血小板活化因子(PAF)水平的影响及其可能的肾功能保护作用。方法:制作大鼠肾毒血清性肾炎模型,随机分为模型组、治疗组及正常对照组。采用银杏叶提取物治疗肾炎大鼠,观察治疗前后大鼠尿中PAF的变化及治疗后血清及肾组织PAF和血肌酐的变化,同时观察银杏叶提取物对该模型动物肾脏病理变化的干预作用。结果:与模型组相比,银杏叶提取物治疗组大鼠24h尿PAF水平及尿蛋白降低(P<0.05);肾组织中PAF含量减少以皮质为明显(P<0.05);同时肾功能(P<0.01)和肾病理改变也得到明显改善。结论:银杏叶提取物可抑制肾毒血清性肾炎大鼠中PAF水平,并对该肾炎大鼠肾功能具有一定的保护作用。 相似文献
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Objective To observe sufety and effect of early enteral feedingthrough jejunum fistulation in postoperation patients with Severe Pancreantitis. Methods 10 patients with severe pancreantitis were set jejunum nutritional tube at point of 90cm apart treiz's ligament during operation.Postoperation 3 day patients were provided low-dose glutamine,5 day were provided low-provided low-dose ELENTAI or VIPEP.Nutritive idex and clinic effects were monitored. Results there is one patient dided in 10 patients,others don/t have indication of clinic relapses and have improvement to many physical indexs,and the days of hospital are shortened.Discussion:1.Pnis a better method for severe pancreantitis,which and improve the nutrition state of the patient with severe pancreantitis,reduce the excretion of pancreas and other digestive glands,but long-term PN can result in intestine mucous atrophy. 2. Severe pancreantitis and destroy the gastric and intestine mucous barrier.PN and early low-dose enteral feeding can protect them,and they will be helpful in obstructing and alleviate the systemic Inflammatory Response Syndrome(SIRS).we have observed that early enteral feeding through jejunum fistulation in postoperation patients with severe pancreantitis doesn't aggravate the burden of pancreas. 3. Enteral nutrition whether aggravates the burden of pancreas is principally decided by the place of provided nutriments,the composition and dose of nutritional liquid. 4. Aims of early enteral feeding throuth jejunum fistulation in postoperation patients with severe oabcreabtutus us oritrct ubtestube nyciys barruer abd akkevuate tge SURS.Most nutrition should be provided by PN. Conclusions early enteral feeding through jejunum fistulation in postoperation patients with severe pancreantitis in feasible,which can replenish some insufficient and speedy recover of patients. 相似文献
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目的 观察血液系统恶性肿瘤血清肿瘤坏死因子α(TNF-α)的变化及临床意义。方法 检测40例血液系统恶性肿瘤患者血清TNF-α的水平。结果 血液系统肿瘤患者血TNF-α水平与对照组相比明显升高。动态观察急性白血病不同病期TNF-α的变化表明:初治与未缓解及复发病人TNF-α水平升高,缓解期下降。结论 TNF-α是血液系统肿瘤病情监测的一个有用指标。 相似文献
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肾小球疾病患者PAF、TNF-α及IL-8的检测 总被引:1,自引:0,他引:1
为进一步探讨肾小球疾病的发病机理,我们在检测血小板活化因子(PAF)的同时,检测患者血清肿瘤坏死因子-α(TNFα)及白细胞介素-8(IL-8)水平变化.报告如下。1资料与方法1.1检测对象我院住院肾小球疾病患者32例,男18例,女14例;年龄14~65岁,平均309岁。分为3组。①慢性肾炎组(12例):除1例肾功能正常外,余均为尿毒症期患者,尿素氮17.3~49.0mmol/L,肌酐506~1800μmol/L)。②肾病综合征组(1例):8例行肾穿刺活检,其中1例失败,成功7例中。轻微病变型2例,系膜增生型2例,膜增殖性肾炎2例,微小病变(膜型肾病早… 相似文献
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一九八一年七至九月,我们在治疗慢性肺心病和抢救肺性脑病中,在综合治疗的基础上,应用654—2进行治疗,取得了明显的效果,现报告如下。一、临床资料本组共6例,男4例,女2例,51—60岁者2例,61—70岁4例,平均年龄65岁。其中肺心病并心哀Ⅱ°—Ⅲ°者4例,同时合并肺性脑病者2例、轻、重型各一例。 (?)治疗方法 相似文献
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