国产安乐嗪棕榈酸酯治疗重性精神病257例临床观察

报告5个单位试用国产安乐嗪棕榈酸酯治疗重性精神病257例的观察资料,显效率为53%,有效率为74%,对精神分裂症各型均有一定疗效,尤以妄想型疗效较好。副作用以锥体外系症状较多见,少数患者呈心电图改变,但多属可逆,未见过敏、中毒反应。剂量以每2～3周1次注射100～200mg 为宜。疗程可为8～16周。本药以长效的优点而适用于拒服药或难坚持服药者。     

调整体内某些物质分子浓度综合治疗精神病(35例初步报告)

近年来精神分裂症的病因研究逐渐深入,各种假说和有关资料颇多,波林(Pan-ling)据各种维生素或某种氨基酸缺乏,常可导致神经精神损伤,于1968年创建“正分子学说”。他认为“正常存在于人体内的某些分子的平衡失调可能是精神分裂症的病因”,主张使用较大量的人体正常存在的一些物质如:维生素、氨基酸作为治疗方法。为了验证这种疗法我们于1974年4-12月用这种疗法试治了35例精神病患者,初获成效,小结如下。一般资料和方法35例均为女性住院患者,年龄19-24岁16例,27-33岁10例,37-48岁9例。发病     

含乌司他丁肺保护液在心肺转流术中的肺保护作用

Objective To evaluate protective effects of hypothermic pulmonary protective solution with uli-nastatin on lung function during cardiopulmouary bypass (CPB) in the patients with congenital heart disease(CHD) and pulmonary hypertenion. Method Fifty-four children,who had CHD of left-to-fight shunts with moderate-se-rious pulmonary hypertension, were enrolled. They had been performed with the radical operation under CPB from September 2005 to December 2006 in the Department of Cardiovascular Surgery, Children' s Hospital of Zhejiang University. Moderate-serious pulmonary hypertension was defined as pulmonary-to-systolic pressure ratio > 0.45(Pp/Ps > 0.45). Fifty-four children were randomly divided into three groups. Patients in group A (n = 18)didn't receive pulmonary protective solution, and scrved as control; patients in group B (n = 18) were adminis-tered with pulmonary protective solution without ulinastatin;patients in group C (n = 18) were administered with pulmonary protective solution with ulinastatin. The serum concentrations of MDA and MPO were measured at five different time points:pre-operation, 0 h, 3 h, 6 h and 24 h in the intensive care unit (ICU) (T1～5). Patients'lung functions were monitored at T1 - T4. The time of mechanical ventilation was recorded. Results No one died in this study. The mean time of mechanical ventilation was shorter in the group B and group C than that in the group A. The MDA and MPO levels were lower in group B compared with group A at T4. The MDA level at T3-T5 and the MPO level at T4 was lower in group C than those in group A. There were no significant in MDA and MPO levels between group B and group C at five time point.A-aDO2 was lower in groups B and C than those in group A at T3 and T4, whereas at T4, A-aDO2 was lower in group C than that in group B. Cdyn was higher in group B at T3and group C at T3 - T4 than those in group A. Cdyn was lower in groups C than that in group B at T4.Condusions Lung perfusion with hypothermic protective solution during CPB can all lung injury and promote recovery after operation, especialy with ulinastatin.     

含乌司他丁肺保护液在心肺转流术中的肺保护作用

目的 评价在先心病伴肺动脉高压患儿心肺转流术期间,从肺动脉灌注含乌司他丁的低温肺保护液对肺脏的保护作用.方法 选择2005-09-2006-12浙江大学医学院附属儿章医院心胸外科收治的左向右分流先心病伴中重度肺动脉高压的患儿54例,中重度肺动脉高压以肺动脉收缩压/体循环收缩压>0.45为标准,手术前有感染征像(白细胞>12 000/μL,体温>38℃,C-反应蛋白>8mg/L)、过敏史者除外.采用抽签法随机分为三组,各18例,A组为对照组(术中未给予肺保护液),B组在术中经肺动脉灌注不含乌司他丁的低温肺保护液,C组在术中经肺动脉灌注含乌司他丁的低温肺保护液.在开胸后及回ICU后0 h,3 h,6 h,24 h(T1～5)五个时点抽取桡动脉血样,测定血浆丙二醛(MDA)、髓过氧化物酶(MPO)浓度;在T1～4计算肺泡-动脉氧分压差(A-aDO2)、肺动态顺应性(Cd).记录呼吸机辅助通气时间.采用SPSS 12.0统计软件对计量指标进行统计分析,资料以均数±标准差(x±s)表示,组间比较用单因素方差分析,组间两两比较用LSD法检验,以P<0.05为差异具有统计学意义.结果 三组患儿回ICU后各时点(T2-5)MDA、MPO值均较T1升高;与A组相比:B组在T4时点MDA、MPO[分别为(7.66±1.42)pg/mL,(194.2±35.41)U/L]显著降低(P<0.05),组C在T3-T5时点MDA[分别为(5.37±1.01)pg/mL,(7.52±0.98)pg/mL,(6.22±0.83)pg/mL]及在T4时点MPO(184.2±35.41)U/L均显著降低;两干预组(B组和C组)各时间点MDA和MPO差异无统计学意义.三组术后A-aDO2升高;与A组相比:B组与C组在T3、T4时点小,但C组在T4时点A-aDO2(72.9±23.94)mmHg较组B(89.2±24.28)mmHg低,差异具有统计学意义.三组术后Cd降低;与A组相比:B组在T3时点[(0.57±0.16)mL·cmH2O-1·kg-1]、C组在T3和T4时点[(0.56 ±0.12)mL·cmH2O-1·kg-1,(0.60±0.11)mL·cmH2O-1·kg-1]高;B组与C组在T4时点Cd差异具有统计学意义.B组与C组呼吸机通气时间较A组短,但两干预组之间差异无统计学意义.结论 低温肺保护液可减轻体外循环对肺的损伤,改善术后早期肺功能,肺保护液中加入乌司他丁对肺脏的保护作用更具有显著性.     

含乌司他丁肺保护液在心肺转流术中的肺保护作用

Objective To evaluate protective effects of hypothermic pulmonary protective solution with uli-nastatin on lung function during cardiopulmouary bypass (CPB) in the patients with congenital heart disease(CHD) and pulmonary hypertenion. Method Fifty-four children,who had CHD of left-to-fight shunts with moderate-se-rious pulmonary hypertension, were enrolled. They had been performed with the radical operation under CPB from September 2005 to December 2006 in the Department of Cardiovascular Surgery, Children' s Hospital of Zhejiang University. Moderate-serious pulmonary hypertension was defined as pulmonary-to-systolic pressure ratio > 0.45(Pp/Ps > 0.45). Fifty-four children were randomly divided into three groups. Patients in group A (n = 18)didn't receive pulmonary protective solution, and scrved as control; patients in group B (n = 18) were adminis-tered with pulmonary protective solution without ulinastatin;patients in group C (n = 18) were administered with pulmonary protective solution with ulinastatin. The serum concentrations of MDA and MPO were measured at five different time points:pre-operation, 0 h, 3 h, 6 h and 24 h in the intensive care unit (ICU) (T1～5). Patients'lung functions were monitored at T1 - T4. The time of mechanical ventilation was recorded. Results No one died in this study. The mean time of mechanical ventilation was shorter in the group B and group C than that in the group A. The MDA and MPO levels were lower in group B compared with group A at T4. The MDA level at T3-T5 and the MPO level at T4 was lower in group C than those in group A. There were no significant in MDA and MPO levels between group B and group C at five time point.A-aDO2 was lower in groups B and C than those in group A at T3 and T4, whereas at T4, A-aDO2 was lower in group C than that in group B. Cdyn was higher in group B at T3and group C at T3 - T4 than those in group A. Cdyn was lower in groups C than that in group B at T4.Condusions Lung perfusion with hypothermic protective solution during CPB can all lung injury and promote recovery after operation, especialy with ulinastatin.     

肺保护液对肺动脉高压患儿体外循环后炎性反应的影响

肺损伤是先天性心脏病患儿体外循环后常见的并发症,在合并肺血管病变如肺动脉高压时肺损伤较为严重,导致动脉氧合不足、肺间质水肿和肺顺应性下降等[1].研究表明,经肺动脉灌注低温肺保护液可明显改善肺动脉高压患儿体外循环后的肺功能[2].本研究拟评价肺保护液对肺动脉高压息儿体外循环后炎性反应的影响,探讨其肺保护作用的可能机制.     

氯氮平副反应84例分析

氯氮平为二苯并杂革类(dibenzol diaze-pine)的衍生物。药理作用较复杂,有抗胆硷能、抗肾上腺能、抗血清素及组织胺作用,具有强大的肌肉松弛和抑制网状系统功能。我国于1976年生     

大剂量哌迷清治疗精神分裂症临床观察

哌迷清(Pimozide)属二苯丁酰哌啶类抗精神病药,对中枢多巴胺受体有阻断作用。口服一次后,8小时血浓度达高峰,半存留期约53小时,被认为系对慢性精神分裂症有效的维持治疗药物.我院于1981年用于临床,对怠性病例也有效。一、一般资料本文共33例,均为精神症状明显,确诊为精神分裂症的住院患者。男17例,女16例。年龄17～54岁,平均33岁。偏执型13例,青春型8例,未定型     

含乌司他丁肺保护液在心肺转流术中的肺保护作用

Objective To evaluate protective effects of hypothermic pulmonary protective solution with uli-nastatin on lung function during cardiopulmouary bypass (CPB) in the patients with congenital heart disease(CHD) and pulmonary hypertenion. Method Fifty-four children,who had CHD of left-to-fight shunts with moderate-se-rious pulmonary hypertension, were enrolled. They had been performed with the radical operation under CPB from September 2005 to December 2006 in the Department of Cardiovascular Surgery, Children' s Hospital of Zhejiang University. Moderate-serious pulmonary hypertension was defined as pulmonary-to-systolic pressure ratio > 0.45(Pp/Ps > 0.45). Fifty-four children were randomly divided into three groups. Patients in group A (n = 18)didn't receive pulmonary protective solution, and scrved as control; patients in group B (n = 18) were adminis-tered with pulmonary protective solution without ulinastatin;patients in group C (n = 18) were administered with pulmonary protective solution with ulinastatin. The serum concentrations of MDA and MPO were measured at five different time points:pre-operation, 0 h, 3 h, 6 h and 24 h in the intensive care unit (ICU) (T1～5). Patients'lung functions were monitored at T1 - T4. The time of mechanical ventilation was recorded. Results No one died in this study. The mean time of mechanical ventilation was shorter in the group B and group C than that in the group A. The MDA and MPO levels were lower in group B compared with group A at T4. The MDA level at T3-T5 and the MPO level at T4 was lower in group C than those in group A. There were no significant in MDA and MPO levels between group B and group C at five time point.A-aDO2 was lower in groups B and C than those in group A at T3 and T4, whereas at T4, A-aDO2 was lower in group C than that in group B. Cdyn was higher in group B at T3and group C at T3 - T4 than those in group A. Cdyn was lower in groups C than that in group B at T4.Condusions Lung perfusion with hypothermic protective solution during CPB can all lung injury and promote recovery after operation, especialy with ulinastatin.     

国产安乐嗪棕榈酸酯治疗100例精神分裂症总结

安乐嗪即哌(口普)嗪(Pipntiazine),是一种新的酚噻嗪类抗精神病药物。安乐嗪和棕榈酸结合而成安乐嗪棕榈酸酯(Pipotiazine Palmitate),简称安棕酯为安乐嗪的长效制剂,肌肉注射后逐渐水解为安乐嗪,是一种酚噻嗪类抗精神病药物,国外于1970年试用于临床。天津市安乐嗪协作组(天津市医药工业研究所,新新制药厂,天津市精神病院)于1978年试制成功,我院1978年8月-1979年7月对100例精神分裂症进行了临床观察,小结如下: