急性一氧化碳中毒迟发性脑病34例分析

急性一氧化碳中毒(acute carbon monoxide poisoning，ACOP)在我国北方是常见、多发病，部分患者经治疗神志清醒后，经过假愈期可出现急性一氧化碳中毒迟发性脑病(delayed encephalopathy after acute carbon monoxide poisoning，DEACMP)。该病发生后，对社会及家庭造成极大的负担。对我院1998-2003年间收治的388例ACOP患者进行治疗及随访观察，     

唐山市城市居民肥胖症患病率现状分析

目的调查唐山市城市居民肥胖症患病率，以期为该地区肥胖症防治工作的开展提供资料。方法随机抽取唐山市城市居民12500人，分为学生组、脑力劳动者组、体力劳动者组、下岗职工组、退休人员组5类。计算各组肥胖症患病率。结果学生组、脑力劳动者组、体力劳动者组、下岗职工组、退休人员肥胖症患病率分别为10．2％，8．42％，9．17％，9．34％，9．05％。结论唐山市城市居民肥胖症患病率较高，应采取有力措施进行干预。     

唐山市城市居民肥胖症患病率现状分析

目的调查唐山市城市居民肥胖症患病率，以期为该地区肥胖症防治工作的开展提供资料。方法随机抽取唐山市城市居民12500人，分为学生组、脑力劳动者组、体力劳动者组、下岗职工组、退休人员组5类。计算各组肥胖症患病率。结果学生组、脑力劳动者组、体力劳动者组、下岗职工组、退休人员肥胖症患病率分别为10．2％，8．42％，9．17％，9．34％，9．05％。结论唐山市城市居民肥胖症患病率较高，应采取有力措施进行干预。     

毒蕈急性中毒15例临床分析

毒蕈俗称毒蘑菇，因其外观与可食的无毒野生蕈相似，易被误采食用而引起中毒。我国已发现毒蕈100余种。由于毒蕈所含毒素不同，中毒后临床表现多样，故给临床诊断和治疗带来一定困难，病死率较高。我们对2000-2004年军事医学科学院附属医院收治的15例毒蕈中毒的诊治经过进行了分析，旨在提高广大医师对该类疾病的认识，及时采取有效的防治措施。     

C-反应蛋白与冠心病关系研究进展

冠心病（coronary heart disease,CHD）发病率在亚洲呈上升趋势，严重威胁着人类的健康．其病因尚未完全阐明。近年来，越来越多的研究证实，炎症在CHD冠状动脉粥样硬化的形成与发展中起着非常重要的作用。C-反应蛋白（C—reactive protein,CRP）是机体非特异性炎症反应的敏感标记物之一．与CHD的发生、发展及预后密切相关．具有新的重要临床意义。现就CRP与CHD的关系综述如下。     

1例妊娠期敌敌畏中毒患者并发急性坏死性胰腺炎分析

目的探讨妊娠期敌敌畏中毒并发胰腺炎的发病机制及有效的治疗方法。方法对患者的临床资料、治疗进行分析。结果本例患者于中毒后第4天并发胰腺炎,经保守治疗好转。但第18天胰腺炎复发并加重,经保守治疗无效死亡。结论妊娠期有机磷中毒易并发胰腺炎,胰腺炎发生后保守治疗疗程应延长,如无效或复发应及时手术治疗。     

唐山市城市居民肥胖症患病率现状分析

目的调查唐山市城市居民肥胖症患病率,以期为该地区肥胖症防治工作的开展提供资料。方法随机抽取唐山市城市居民12500人,分为学生组、脑力劳动者组、体力劳动者组下岗职工组、退休人员组5类。计算各组肥胖症患病率。结果学生组、脑力劳动者组、体力劳动者组、下岗职工组、退休人员肥胖症患病率分别为10.2%,8.42%,9.17%,9.34%9.05%。结论唐山市城市居民肥胖症患病率较高,应采取有力措施进行干预。     

百草枯中毒肺纤维化患者血清基质金属蛋白酶及其抑制剂水平的变化

目的探讨血清基质金属蛋白酶-9(MMP-9)、金属蛋白酶组织抑制剂-1(TIMP-1)在百草枯(PQ)中毒肺纤维化患者中的动态变化。方法 30例健康对照组于受检时,30例PQ中毒患者于入院时及入院后7 d、14 d、28 d抽取静脉血,采用酶联免疫吸附法(ELISA)检测血清MMP-9和TIMP-1的水平。结果 PQ中毒患者入院时、入院后7 d、14 d血清MMP-9水平较对照组明显升高,差异有统计学意义(P<0.05)。PQ中毒患者入院后7d血清MMP-9水平较入院时及入院后14 d均明显升高,差异有统计学意义(P<0.05),PQ中毒患者血清MMP-9水平于入院后7 d达高峰。PQ中毒患者入院后7 d、14 d、28 d血清TIMP-1水平较对照组明显升高,差异有统计学意义(P<0.05)。PQ中毒患者入院后14 d血清TIMP-1水平较入院后7 d明显升高,差异有统计学意义(P<0.05),PQ中毒患者血清TIMP-1水平于入院后14 d达高峰。结论 MMP-9和TIMP-1在PQ中毒肺纤维化的发病机制中起重要作用。     

C-反应蛋白水平及其基因型差异对急性心肌梗死预后的影响

目的探讨C-反应蛋白(CRP)水平与基因型对急性心肌梗死(AMI)预后的影响。方法采用免疫比浊法检测151例AMI患者血清高敏CRP含量,聚合酶链反应-限制性片段长度多态法检测其CRP1059G/C基因型,对照组为80例健康者。观察AMI患者冠状动脉狭窄程度,预后情况并进行分析。结果AMI患者基因型分布:GG型119例,GC型25例,CC型7例。基因型分布与对照组间差别无显著性意义(P>0.05)。3型患者入院时、入院后1周及2周时CRP水平及持续时间间差别均有显著性意义(P<0.01)。不同CRP基因型的AMI患者冠状动脉狭窄程度间差别有显著意义(P<0.05)。不同CRP基因型的AMI患者预后情况间差别亦有显著性意义(P<0.01)。结论AMI患者CRP基因型分布与健康人群无差别。GG基因型者CRP水平高于GC、CC型,冠状动脉狭窄程度亦较其他两型严重,且预后差。AMI患者的预后可能受CRP基因型影响。     

吸入上转换纳米颗粒对小鼠肺肝均有一过性损害

BACKGROUND: Lots of in vitro experiments have explored the toxicity of upconversion nanoparticles, but its toxicity in vivo is little reported. OBJECTIVE: To investigate the toxicity of upconversion nanoparticles in mouse organs. METHODS: After tracheotomy, 36 Balb/c mice were randomly divided into three groups, followed by instilled with 28 mg/kg upconversion nanoparticle (experimental group), the same volume of normal saline (control group), and nothing (sham operation group), respectively. The functional changes of the lung, liver and kidney were detected at 1 day, 1 and 2 weeks postoperatively, and meanwhile, the morphological changes of the lung, liver, kidney, and heart were observed. RESULTS AND CONCLUSION: At 1 day postoperatively, the pH values in the experimental group were lower than those in the control and sham operation groups (P < 0.05), while the glutamic-pyruvic transaminase level was higher than that in the control and sham operation groups (P < 0.05). The oxygen partial pressure in the sham operation group was higher than that in the other two groups at 1 day postoperatively (P < 0.05). The oxygen partial pressure and glutamic-pyruvic transaminase level did not significantly differ among groups at 1 and 2 weeks postoperatively. The carbon dioxide differential pressure and kidney function showed no significant differences among groups at different time points after surgery. At postoperative 1 day, in the experimental group, hyperplasia and inflammation were most obvious, distorted alveolar cavity and congestion of blood vessels were visible. In the control group, obvious hyperplasia and inflammation were found, the alveolar cavity was crimped and the gap between alveoli was broadened. The sham operation group had normal alveoli with no inflammations. Lung lesions in the experimental and control groups became mild with time at postoperative 1 and 2 weeks. One day postoperatively, hepatocyte swelling and vacuolar degeneration were severer in the experimental group. Moderate hepatocyte swelling and vacuolar degeneration occurred in the control group. The sham operation group showed mild hepatocyte swelling and vacuolar degeneration. The morphology of the liver in each group returned to normal at 2 weeks postoperatively. Fortunately, the heart and kidney structure showed no overt changes in each group. These findings suggest that upconversion nanoparticles cause transient damage to the mouse lung and liver.