负压对机械转流管道中血流溶血过程的影响

机械性辅助循环对挽救心泵功能衰竭病人的生命具有重要价值[1] 。但应用机械血泵进行心脏辅助可引起一些重要的并发症 ,如溶血和血栓形成等 ,亟待进一步解决[2 ,3] 。在正常条件下 ,血细胞生存的压力环境基本处于正压区 ,因此 ,需确定机械性循环时非生理环境因素的影响。目前尚缺乏相应的研究文献揭示负压与机械转流管道中血流溶血过程的关系。本试验探讨了负压对机械性溶血的影响 ,对辅助装置的临床应用提供指导。1　材料和方法模拟循环线路如图 1所示。图 1　模拟循环线路示意图　　模拟循环系统包括离心式血泵(由本研究室自制 ) ,泵输入 …     

Clinical use of left ventricular assist in coronary artery surgery.

Objective To review the experience of using left ventricular assist (LVAD) in coronary artery bypass grafting (CABG). Methods The data of 1 704 CABG cases were analyzed. 25 patients required LVAD after CABG (1. 5% ,25/1704). Results About 78% of 25 patients were weaned off LVAD, and 48% of them were discharged. IABP was used in 88% of patients. The major complications were MOF,lung disease,renal insufficiency/ failure, arrhythmia, coapulopathy, and infection. The causes of death were MOF, pump failure, renal failure, venticular fibrillation, respiratory failure, bleeding. Conclusion LVAD is a very useful tool in salvaging left ventricular failure. LVAD should be used as early as possible. Before weaning, trials should be madeat decreasing flow rates. 11 refs,2 tabs.