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目的研究分析恶性肿瘤患者凝血和纤溶指标变化的临床意义,并提供相应的护理对策。方法选取2011年5年至2015年5月我科诊治的63例恶性肿瘤患者作为观察组,同期在我院进行体检的63例健康者作为对照组,对比分析其凝血指标[活化部分凝血活酶时间(aPTT),凝血酶原时间(PT),纤维蛋白原(Fbg),凝血酶时间(TT)]和纤溶指标[纤维蛋白降解产物(FDP),D二聚体(D-D)],并结合临床症状总结相应的护理对策。结果恶性肿瘤患者凝血及纤溶指标较健康对照组均增高,且组间比较差异有统计学意义(P0.05)。结论恶性肿瘤患者的确存在凝血系统激活和继发纤溶亢进现象,应引起重视,给予相应的护理政策降低不良事件发生率。 相似文献
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目的探讨质量安全持续改进追踪在危急值管理中的作用。方法采集2017年1月至2018年12月本科LIS系统及危急值报告登记本中血细胞分析的数据,用统计学方法对假危急值数据进行比较分析。结果统计314038例数据共检测危急值963例,其中2017年发生危急值462例,假危急值32例,假危急值率6.93%;2018年应用持续改进追踪后发生危急值501例,假危急值6例,假危急值率1.197%,与前者比较,降低率为81.25%。结论实施质量安全持续改进追踪,可提高危急值报告准确性,提升科室管理水平,降低安全事故的发生。 相似文献
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This study examined the mechanism of the inhibitory effect of parthenolide(PTL) on the activity of NF-κB in multiple myeloma(MM). Human multiple myeloma cell line RPMI 8226 cells were treated with or without different concentrations of PTL for various time periods, and then MTT assay was used to detect cell proliferation. Cell cycle and apoptosis were flow cytometrically detected. The level of protein ubiquitination was determined by using immunoprecipitation. Western blotting was employed to measure the level of total protein ubiquitination, the expression of IκB-α in cell plasma and the content of p65 in nucleus. The content of p65 in nucleus before and after PTL treatment was also examined with immunofluorescence. Exposure of RPMI 8226 cells to PTL attenuated the level of ubiquitinated Nemo, increased the expression of IκB-α and reduced the level of p65 in nucleus, finally leading to the decrease of the activity of NF-κB. PTL inhibited cell proliferation, induced apoptosis and blocked cell cycle. Furthermore, the levels of ubiquitinated tumor necrosis factor receptor-associated factor 6(TRAF6) and total proteins were decreased after PTL treatment. By using Autodock software package, we predicted that PTL could bind to TRAF6 directly and tightly. Taken together, our findings suggest that PTL inhibits the activation of NF-κB signaling pathway via directly binding with TRAF6, thereby suppressing MM cell proliferation and inducing apoptosis. 相似文献
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【摘要】 目的 探讨胃癌组织中核磷蛋白(NPM)的表达与各临床病理因素的关系,评估其在胃癌侵袭转移过程中的作用及预测胃癌患者预后的价值。方法 采用免疫组化法检测胃癌和癌旁组织中NPM的表达情况,并评估NPM表达与临床病理因素之间的关系。用Kaplan Meier法及单因素和多因素分析来评估胃癌患者的术后生存率。结果 胃癌组织中NPM阳性表达率为659%(54/82例),与癌旁组织中的阳性表达率(194%)比较差异有显著性(P<0001);NPM阳性表达率与Lauren’s分型(P=0.025)、淋巴结转移(P=0.001)、浸润深度(P=0.010)、临床分期(P=0.033)及复发(P=0.006)等显著相关。 胃癌患者的生存分析显示,NPM阴性组和阳性表达组生存率之间差异有显著性(P=0.021)。结论 NPM 高表达与胃癌的浸润和转移密切相关,可以作为预测胃癌预后的一个生物学指标。 相似文献
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