合川区煤矿工人职业病防治知识知晓调查分析

目的了解合川区煤矿工人的人群特征和对职业病防治知识知晓情况,评价《职业病防治法》实施以来职业病健康促进工作对煤矿工人的影响,为今后进一步加强职业病防治健康教育和健康促进提供科学依据。方法使用统一设计的调查问卷对合川辖区内煤矿生产企业在岗的从业人员进行了抽样调查。结果绝大多数煤矿工人的文化程度为文盲或小学,对职业病防治知识知晓少,获取职业病防治知识的主要途径是人际传播。结论应将煤矿工人作为重点人群进行宣传教育,将职业病防治知识及相关政策作为重点内容,提高煤矿工人的职业病防治意识。     

肺康复运动训练治疗间质性肺疾病患者的研究进展

间质性肺疾病（ILD）属于难治性呼吸系统疾病,主要累及肺间质、细支气管和（或）肺泡,最终导致肺纤维化,严重影响患者的生命质量。肺康复训练治疗ILD患者能够显著改善肺功能,其中运动训练是肺康复训练的基石。针对不同症状的ILD患者,制订不同的肺康复运动训练形式、时间、强度,并定期进行科学的督导,可持久地提高康复效果。本研究综述肺康复运动训练治疗间质性肺疾病患者的研究进展,以供临床参考。     

辛伐他汀联合低分子肝素治疗不稳定型心绞痛40例疗效分析

目的 探讨辛伐他汀联合低分子肝素对不稳定型心绞痛的治疗作用。方法 82例不稳定型心绞痛随机分为两组，治疗组40例，给予低分子肝素5000u皮下注射12h／1次辛伐他汀40mg每晚一次；对照组42例，给予硝酸酯、阿司匹林、钙拮抗剂和β-受体阻滞剂。结果 治疗组优于对照组。结论 辛伐他汀联合低分子肝素治疗不稳定型心绞痛有良好效果。     

糖友四招自查糖尿病足

糖尿病患者有的会出现足部病变,此种病变一定要引起重视。如果不进行有效治疗和干预,可能会有截肢危险。据资料显示,糖尿病患者截肢率比非糖尿病患者高10倍以上,而在所有非创伤性截肢中,糖尿病足所致占50%以上。     

胆肠Roux-en-Y吻合术、胆管修补＋T管引流术治疗复杂医源性胆道损伤的远期并发症比较

目的 比较胆肠Roux-en-Y吻合术与胆道修补＋T管引流术治疗复杂医源性胆道损伤的远期并发症发生情况的差异.方法 对64例复杂医源性胆道损伤患者分别行胆肠Roux-en-Y吻合术及胆道修补＋T管引流术治疗,比较两种术式的远期并发症发生率.结果 术后随访1～8年,行胆肠Roux-en-Y吻合术患者的术后胆漏、胆道狭窄、胆管炎、黄疸、胆道结石发生率明显低于行胆道修补＋T管引流术者（P均＜0.05）.结论 胆肠Roux-en-Y吻合术是治疗复杂医源性胆道损伤较好的术式,其术后远期并发症发生率低于行胆道修补＋T管引流术者,值得临床推广应用.     

沉默LncRNA HOXD-AS1调控miR-454-3p表达增加H460细胞放射敏感性

目的 探究LncRNA HOXD-AS1靶向调控miR-454-3p表达对肺癌H460细胞放射敏感性影响。方法 qRT-PCR检测HOXD-AS1、miR-454-3p表达量,流式细胞术检测细胞凋亡率,克隆实验检测细胞放射敏感性。蛋白印迹法检测细胞中Caspase-3、Cyclin D1、γ-H2AX的蛋白表达量。结果 照后细胞中HOXD-AS1表达升高(P<0.05),miR-454-3p表达降低(P<0.05)。沉默HOXD-AS1促进细胞凋亡、增加放射敏感性,促进Caspase-3、γ-H2AX蛋白表达,抑制Cyclin D1表达;HOXD-AS1可靶向结合miR-454-3p并可负向调控其表达。结论 沉默HOXD-AS1可靶向调控miR-454-3p促进肺癌细胞凋亡及抑制细胞存活进而提高放射敏感性。     

人羊膜间充质干细胞移植修复肝脏缺血-再灌注损伤

BACKGROUND:Studies have shown that human amniotic mesenchymal stem cells can differentiate into hepatocyte-like cells, suggesting that human amniotic mesenchymal stem cell transplantation provides a new potential for the clinical treatment of liver diseases. OBJECTIVE:To observe the effect of human amniotic mesenchymal stem cell transplantation on the repair of liver ischemia-reperfusion injury repair. METHODS:Sixty Sprague-Dawley rats were randomized into stem cell transplantation, model and control groups. Animal models of liver ischemia-reperfusion injury were made in the rats in the stem cell transplantation and model groups. One hour after modeling, rats in the stem cell transplantation were given injection of human amniotic mesenchymal stem cells (0.5 mL, 106 cells) via the tail vein, while rats in the model and control group were given L-DMEM (0.5 mL) or normal saline (0.5 mL), respectively. Liver function and liver morphology were detected at 1, 2, 3 weeks after transplantation. Meanwhile, RT-PCR detection and western blot assay were also conducted. RESULTS AND CONCLUSION:(1) Liver function: Compared with the control group, levels of aspartate aminotransferase, alanine aminotransferase and malondialdehyde were significantly increased in the model group at different time points after transplantation (P < 0.05), while a significant reduction in the levels of these three indicators was found after cell transplantation as compared with the model group (P < 0.05). (2) Liver morphology: 2 weeks after transplantation, rats in the model group exhibited hepatocyte degeneration and necrosis, and severe fibrosis, but these changes were remarkably alleviated in the stem cell transplantation group. (3) PT-PCR and western blot detection: 2 weeks after transplantation, a significantly higher level of hepatocyte growth factor in the liver tissue and a lower level of α-smooth muscle protein were found in the stem cell transplantation group compared with the model group (P < 0.05). All these experimental findings indicate that human amniotic mesenchymal stem cell transplantation can improve impaired liver function in rats, possibly through regulating hepatocyte growth factor and α-smooth muscle protein expression levels in the liver, and thereby promotes the repair of liver ischemia-reperfusion injury.     

一起副溶血性弧菌食物中毒的调查

目的：了解食物中毒的发生经过及原因,为此类事件的预防和监督管理提供参考。方法：采用流行病学、现场卫生学调查及实验室检测等方法进行调查分析。结果：本次食物中毒发病47例,罹患率约为7.12%（47/660）;潜伏期8-18 h,平均13 h;中毒的主要原因是进食被副溶血性弧菌污染的食品所致,具体中毒食物不明。结论：本事件为副溶血性弧菌引起的食物中毒,提出了预防类似食物中毒的监督管理和预防控制措施。     

多发颈淋巴结结核48例疗效分析

目的:探讨多发颈淋巴结结核治疗方法及疗效。方法:将48例多发淋巴结结核随机分实验组和对照组,均予全身抗结核治疗,但实验组予自制异烟肼 利福平注射液(唯夫欣,重庆华邦制药) 链霉素 利多卡因溶液,逐个注入肿大淋巴结,破溃者彻底清除坏死物后,填充入浸泡上述自制药液纱条。结果:实验组有效率92.0%,对照组64.2%。实验组6例破溃淋巴结均治愈,对照组10例中有2例未愈。结论:全身积极抗结核同时配合局部淋巴结治疗,能取得满意疗效。     

温阳益心汤联合参麦注射液治疗充血性心衰的效果观察

目的:观察温阳益心汤联合参麦注射液治疗充血性心衰的效果.方法:选取2012年6月—2020年6月于我院接受治疗的122例充血性心衰患者,通过抽签随机分成参照组和联合组各61例,对参照组的61例.患者进行参麦注射液治疗,对联合组的61例患者进行温阳益心汤联合参麦注射液治疗,对比两组患者治疗后的中医症状积分和治疗前后心脏超...