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对20例心肌梗塞(MI)患者及与之配对的20例糖尿病患者、20例正常人的红细胞胰岛素受体进行测定,并根据Scatchard曲线计算受体的高、低亲和力位点数(Q1、Q2)及亲和力常数(K1、K2)。结果显示MI组K1、Q2、K2均低于正常对照组,K2亦低于糖尿病组,糖尿病组K1、Q2亦低于正常对照组。提示MI患者胰岛素抵抗可能与胰岛素受体异常有关,胰岛素受体缺陷、胰岛素抵抗、高胰岛素血症三者交互影响可能在MI的发病中有重要作用。 相似文献
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目的:探讨老年肺结核的X线特点,提高诊断准确率。方法:回顾分析我科2008年5月--2011年5月的78例老年肺结核患者胸部X线平片资料。结果:老年性肺结核累及双肺,以浸润型肺结核为主。结论:老年肺结核x线乎片表现复杂,正确分析胸部X线平片,对老年肺结核的诊断和治疗有重要意义。 相似文献
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ATP敏感性钾通道与心肌保护 总被引:2,自引:0,他引:2
在生理状态下,ATP敏感性钾通道处于失活状态,急性心肌缺血及心肌肥厚时该通道被激活,这可能是一种重要的心肌内源性保护机制。 相似文献
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病历资料
患者,男,66岁,查体时发现左肺上叶占位.CT检查左肺上叶占位,考虑恶性肿瘤.行左肺上叶切除术.
病理检查:①大体检查:切除一叶肺,20cm×11cm×6cm大小,肺膜表面大部分光滑,完整.距外缘2cm处有结节状聚积,面积0.4cm×0.3cm.沿支气管切开肺,距支气管断端5cm近肺膜下见灰白灰黄色肿物,大小为4cm×3cm×2cm,切面灰白灰黄色,质地较硬. 相似文献
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<正>支气管肺癌是肺部最常见的恶性肿瘤之一,同时也是人类因癌致死的首要原因。早期诊断较困难,5年生存率低于15%[1],因此肺癌的早期诊断及治疗非常重要。周围型小肺癌是指病变直径<2cm的恶性结节,由于病变较小特别是在隐蔽部位的病 相似文献
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OBJECTIVE: To determine the effects of HOE 694, a new and potent Na(+)-H+ exchanger blocker, on transient inward current (It(i)) and Na(+) - Ca(2+) exchange during hypoxia-reoxygenation in guinea pig cardiomyocytes. METHODS. Cardiomyocytes were isolated from adult guinea pig ventricle. Experiment was performed in an experimental chamber that allowed the cells to be exposed to a sufficiently low O2 pressure. The cells were subjected to hypoxia and reoxygenation. The ionic currents were studied with patch clamp technique. RESULTS: In the absence of HOE 694, hypoxia-reoxygenation induced It(i) in 12 of 15 experiments; but in cardiomyocytes pretreated with HOE 694 (10 approximately 50 micro mol/L), the incidence of It(i) observed during reoxygenation was reduced to 5 of 11 experiments and 3 of 10 experiments, P < 0.05 vs control respectively. The Na(+) - Ca(2+) exchange current was unaffected by HOE 694 under normoxic condition. However, when cells were pretreated with 10 micromol/L HOE 694 for 10 min, then subjected to hypoxia condition, the Na(+) - Ca(2+) exchange current significantly inhibited. CONCLUSIONS: Blockade of the Na(+)-H+ exchange by HOE 694 could reduce Ca(2+) overload upon hypoxia-reoxygenation, and inhibition of Na(+) - H+ exchange may also indirectly decrease Na(+) - Ca(2+) exchange activity during hypoxia. 相似文献
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NTRODUCTION Several studies have provided evidences that blockade of the Na+- H+ exchange with amiloride or its congeners is associated with the protection of heart from arrhythmias and calcium overload during ischemia and reperfusion. It also has been shown that amiloride attenuates the rise of cytosolic Ca2+ during ischemia and prevents Na+ and Ca2+ overload on reperfusion(1, 2).How-ever, although the protective effects of amiloride against cardiac arrhythmias and contractile dysf… 相似文献