全文获取类型
收费全文 | 9378篇 |
免费 | 458篇 |
国内免费 | 85篇 |
专业分类
耳鼻咽喉 | 69篇 |
儿科学 | 226篇 |
妇产科学 | 304篇 |
基础医学 | 950篇 |
口腔科学 | 175篇 |
临床医学 | 813篇 |
内科学 | 2569篇 |
皮肤病学 | 68篇 |
神经病学 | 968篇 |
特种医学 | 455篇 |
外科学 | 1363篇 |
综合类 | 22篇 |
一般理论 | 3篇 |
预防医学 | 382篇 |
眼科学 | 134篇 |
药学 | 583篇 |
中国医学 | 19篇 |
肿瘤学 | 818篇 |
出版年
2023年 | 54篇 |
2022年 | 161篇 |
2021年 | 283篇 |
2020年 | 148篇 |
2019年 | 246篇 |
2018年 | 307篇 |
2017年 | 228篇 |
2016年 | 247篇 |
2015年 | 281篇 |
2014年 | 382篇 |
2013年 | 469篇 |
2012年 | 738篇 |
2011年 | 713篇 |
2010年 | 375篇 |
2009年 | 400篇 |
2008年 | 577篇 |
2007年 | 560篇 |
2006年 | 563篇 |
2005年 | 575篇 |
2004年 | 513篇 |
2003年 | 485篇 |
2002年 | 435篇 |
2001年 | 92篇 |
2000年 | 80篇 |
1999年 | 91篇 |
1998年 | 86篇 |
1997年 | 87篇 |
1996年 | 71篇 |
1995年 | 55篇 |
1994年 | 50篇 |
1993年 | 34篇 |
1992年 | 57篇 |
1991年 | 41篇 |
1990年 | 41篇 |
1989年 | 22篇 |
1988年 | 41篇 |
1987年 | 29篇 |
1986年 | 37篇 |
1985年 | 34篇 |
1984年 | 22篇 |
1983年 | 27篇 |
1982年 | 26篇 |
1981年 | 24篇 |
1980年 | 20篇 |
1979年 | 9篇 |
1978年 | 12篇 |
1977年 | 10篇 |
1974年 | 10篇 |
1972年 | 13篇 |
1968年 | 8篇 |
排序方式: 共有9921条查询结果,搜索用时 15 毫秒
1.
2.
Federigo Sicuteri Maria Nicolodi Bruno Marcello Fusco Salvatore Orlando 《Headache》1991,31(9):577-581
Following tooth pulp extirpation, some subjects suffer from persistent pain which affects edentate sites in absence of any local pathology. As regards this peculiar pain, called phantom tooth pain (PTP), what is puzzling is the fact there is a low prevalence of PTP in a very large population showing identical conditions of tooth pulp extirpation. The present investigation indicates that PTP mainly affects migraine (M) and cluster headache (CH) sufferers, whereas it does not affect subjects who have a negative personal and family history for idiopathic headache (IH). These results circumscribe the presence of PTP to a specific section of the population. The present results, besides indicating that PTP may be the result of a peculiar neuronal predisposition relating to IH pathogenesis, suggests some practical therapeutic hints. In fact, successful anti- M and anti-CH prophylactic treatment greatly improve PTP syndrome. 相似文献
3.
4.
Cesario Bellantuono Giovanni Migliarese Salvatore Gentile 《Human psychopharmacology》2007,22(6):413-413
Hum Psychopharmacol 2007; 22 : 121–128. DOI: 10.1002/hup.836 It has come to our attention that there was an error contained in the above article within the abstracts heading relating to Methods. The article stated that: ‘A literature search was conducted within PsychoINFO’. This should have been published as: ‘A literature search was conducted within PsycINFO’. We apologise for this anomaly. 相似文献
5.
6.
Tolerance of ocular iontophoresis in healthy volunteers. 总被引:4,自引:0,他引:4
Thomas M Parkinson Elizabeth Ferguson Salvatore Febbraro Arash Bakhtyari Martin King Mohan Mundasad 《Journal of ocular pharmacology and therapeutics》2003,19(2):145-151
To evaluate ocular tolerance, healthy volunteers were iontophoresed transclerally using novel OcuPhor trade mark hydrogel drug delivery applicators filled with balanced salt solution. In this three-period crossover study in 24 male and female subjects, 16 subjects received 0 mA and two of the following DC currents: 0.1, 0.5., 1.0, 2.0, 3.0, or 4.0 mA for 20 min; 6 subjects received 3 mA for 20 min and 1.5 mA for 40 min (both equivalent to 60 mAmin total charge). Safety and tolerance were determined by subjective VAS and objective ophthalmic assessments. Subjects were evaluated before and up to 22 hr after dosing. The applicators were well-tolerated and no clinically significant changes in symptomology or in ophthalmic assessments were seen following exposure to 0-3.0 mA for 20 min or 1.5 mA for 40 min. At 4.0 mA 2 of 4 subjects reported a burning sensation under the applicator during dosing which resolved by 22 hr post-dose; superficial changes in fluorescein staining were observed at 1 hr, but not at 22 hr. The OcuPhor trade mark system has promise for noninvasive drug delivery to the eye. 相似文献
7.
The prevalence of bad self-rated health (SRH) varies considerably across countries. Here we present the results of a cross-national comparative study based on the data of National Health Surveys conducted in France and Italy. According to these data, 11% of the Italian and 6% of the French adult population aged between 45 and 74 rate their health as bad or very bad. This gap may result from differences in population structure regarding the individual characteristics (sociodemographic characteristics, diseases and disabilities, lifestyle, and others) that impact on SRH i.e., a structural effect. It may also be that the link between these characteristics and SRH is “country-specific” i.e., a contextual effect. We use logistic regression models to assess the contribution of both explanations. We find that the structural effect plays a prominent role in the higher prevalence of bad SRH in Italy compared to France. 相似文献
8.
Floriano P Silva-Junior Herbert L M Guedes Laura C Garvey Aniesse S Aguiar Saulo C Bourguignon Enrico Di Cera Salvatore Giovanni-De-Simone 《Toxicon》2007,50(1):18-31
BJ-48, a serine protease from the venom of Bothrops jararacussu, was purified to homogeneity using affinity chromatography on p-aminobenzamidine-agarose followed by HPLC gel filtration. BJ-48 presented 52kDa by SDS-PAGE analysis and 48,036Da by electron spray mass spectrometry. The enzyme was shown to be highly glycosylated with 42% of N-linked carbohydrates composed of Fuc(1):GalN(4):GlcN(5):Gal(1):Man(2) and a high content of sialic acid residues (8-12%). BJ-48 had optimal esterase activity at pH 7.5 and displayed maximum catalytic rate at 50 degrees C. Its hydrolytic activity was strongly inhibited by aprotinin and dithiothreitol while N-tosyl-l-phenylalanine chloromethyl ketone, 6-aminocaproic acid, E-64 and soybean trypsin inhibitor (SBTI) were ineffective. The kinetics of BJ-48 with chromogenic substrates revealed an unprecedented selectivity (10(4)-fold) for Arg over Lys in P1. BJ-48 proved to be a thrombin-like enzyme (TLE) with a specific fibrinogen-clotting activity of 73.4NIH units/mg. The TLE rapidly digested human fibrinogen Bbeta chain, but the Aalpha chain was cleaved specifically to release fibrinopeptide A with k(cat)/K(m)=2.1muM(-1)s(-1). The TLE showed no activity toward other thrombin substrates like protein C, protease-activated receptor-1 or inhibitors such as hirudin and antithrombin. A non-denaturing procedure using PNGase F and neuraminidase followed by hydrophobic interaction chromatography was employed to obtain active BJ-48 forms with variable carbohydrate content. Compared to the native enzyme, total or partially deglycosylated BJ-48 forms presented up to 2-fold reduction in their specific activities upon heating at 55/65 degrees C or treatment with SBTI. These results point out a role for BJ-48 glycosylation in thermostability and controlling the access of some canonical protein inhibitors to the active site. 相似文献
9.
10.