Modulatory effect on dyslipidemia and anti-atherosclerotic function of Xuezhikang in newly diagnosed type 2 diabetes patients

The modulatory effect of Xuezhikang on dyslipidemia and the preventive effect on atherosclerosis in newly diagnosed type 2 diabetic patients were studied. A prospective clinical trial was conducted to test the effectiveness of Xuezhikang in selected 201 newly diagnosed type 2 diabetic patients. All patients were randomly divided into two groups: 108 with Xuezhikang therapy and 93 without Xuezhikang therapy. The mean follow-up period was 22 months. The blood glucose and blood pressure of all patients were under control. Serum levels of total cholesterol (TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) were significantly lowered and their decreased percentages were significantly higher in Xuezhikang therapy group (P < 0.05). The number of patients with arteria iliaca intima thickening was significantly lower in group of Xuezhikang therapy (P = 0.024). With stepwise multivariate logistic regression analysis, the decreased percentage of TG was significantly and independently related with the decreased number of patients with arteria iliaca intima thickening (P = 0.005). The study demonstrates that Xuezhikang therapy is effective on modulating dyslipidemia in newly diagnosed type 2 diabetes patients, and may be related with the improvement of early atherosclerosis. __________ Translated from Chinese Journal of Geriatrics, 2007, 26(8): 584–586 [译自: 中华老年医学杂志]]     

何首乌及其混伪品鉴别检索(Ⅱ显微特征)

报道何首乌及其混伪品的显微特征检索,从组织结构、粉末特征与原植物分类检索排序的一致性表明,显微特征和植物来源之间有一定的规律可循。     

人参皂甙Rg3对耐顺铂人肺腺癌细胞系A549DDP逆转作用及其机理的研究

目的探讨人参皂甙Rg3对耐顺铂(CDDP)人肺腺癌细胞系A549DDP的逆转作用及其机理.方法以A549DDP及其亲本细胞A549为研究对象,MTT法观察Rg3对A549DDP耐药的逆转作用,采用免疫组化及RT-PCR方法分别在蛋白质和mRNA水平检测耐药相关蛋白MDR1、MRP、LRP表达.结果 MTT法显示低细胞毒浓度Rg3(10 μmol)有效逆转A549DDP细胞耐药7.3倍,而20、30 μmol Rg3分别逆转耐药1.3、1.2倍;10 μmol Rg3预处理A549DDP细胞12、24、36及48 h后分别逆转耐药1.0、1.6、7.6及10.4倍,表明Rg3逆转耐药呈时间依赖性.免疫组化和RT-PCR显示:A549DDP细胞MDR1、MRP、LRP呈过量表达,以Rg3(10 μmol)预处理A549DDP 12、24、36及48 h后,MDR1、MRP表达减弱,呈时间依赖性,而LRP表达无明显时间依赖性.结论 Rg3具有中度逆转肿瘤耐药作用,并呈时间依赖性.     

盐酸帕罗西汀治疗胃肠疾病433例分析

常见胃肠疾病的临床症状常是非特异性及多样性,其中或多或少受到精神因素的影响［１］。为探索针对调整神经功能失调药物在治疗胃肠疾病中的作用,自１９９７年５月至１９９８年７月,我们在常规药物治疗的基础上加用盐酸帕罗西汀（赛乐特）治疗常见胃肠疾病４３３例,疗效满意,现报告如下。材料与方法一、研究对象４３３例胃肠疾病均依据临床表现、内镜、实验室及影象学检查明确诊断,其表１　主要胃肠道症状及治疗效果（例）恶心呕吐腹痛腹胀暖气大便次数及习惯改变吞咽障碍或吞咽不协调病例数１５６１２８８２４３１０有效数１３２１１…     

The combination of mifepristone and misoprostol for the termination of pregnancy

The combination of 200 mg of mifepristone followed by 25 μg to 800 μg (depending on gestational age) of misoprostol has been shown to be effective for the termination of pregnancy throughout gestation. The dose of misoprostol should be reduced as gestational age increases. Mifepristone is not indicated for induction of labor with a live fetus because there are no data to confirm that it does not have a possible deleterious fetal effect. The course of treatment and prerequisites for medical abortion and recommended mifepristone and misoprostol regimens for different gestational ages are described, along with the side effects, management of complications, and postabortion care. The use of the mifepristone-misoprostol combination regimen for induction of labor in cases of fetal death is also described.     

动脉壁正常区与脂斑区血小板源性生长因子及其受体基因表达的比较

应用Ｎｏｒｔｈｅｒｎ印迹分析技术测定了正常人主动脉平滑肌细胞血小板源性生长因子（ｐｌａｔｅｌｅｔｄｅｒｉｖｅｄｇｒｏｗｔｈｆａｃｔｏｒ，ＰＤＧＦ）及其受体ｍＲＮＡ的表达，以探讨其与动脉粥样硬化（ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ，Ａｓ）发生的关系。结果显示，正常动脉壁及有脂纹脂斑动脉的正常区ＰＤＧＦ链ｍＲＮＡ仅有微量表达，未检出ＰＤＧＦ受体ｍＲＮＡ的表达；而脂纹脂斑区的ＰＤＧＦＡ链ｍＲＮＡ及ＰＤＧＦβ－受体ｍＲＮＡ表达则显著增高。提示动脉壁ＰＤＧＦＡ链及ＰＤＧＦ受体ｍＲＮＡ表达增高与Ａｓ的发生有关。     

驳与证伪;;科学的预测;;包容性;;替代经济学作

醚У男铝髋刹愠霾磺?其鲜活性对研究者和爱好者都具有强烈吸引,它在学术上的无所不包使得它没有替代品。Economics:The Supply of and Demand for a ProductSHI Lu-ming(School of International Economics,Guizhou College of Finance and Economics,Guiyang,Guizhou 550004,China)The striking status of economics in China can be interpreted in its supply and demand as a product.On the one hand,market-oriented reforms in China have generated the basic demand for knowledge in economics,and economic theory itself displays an interpretational power more robust than other theories.On the other hand,the falsifiability and refutability and constant renewal of economic theory,concerns of economists over the realities,and openness of economic research have made economics a highly inclusive and open system free from ideological shackle