OBJECTIVE: We wanted to compare the efficacies of 95% ethanol and 20% hypertonic saline (HS) sclerotherapies that were performed in a single session under CT guidance for the management of simple renal cysts. MATERIALS AND METHODS: A prospective series of 74 consecutive patients (average age: 57.6 +/- 8.1 years) with simple renal cysts were enrolled in this study. They were randomized into two groups and 95% ethanol or 20% HS, respectively, corresponding to 25% of the aspiration volume, was injected. Treatment success was determined six months later with follow-up clinical evaluation and performing ultrasonography. RESULTS: The sclerotherapy was accepted as technically successful without major complications in all except two patients who were excluded because of a communication between the simple renal cyst and the pelvicalyceal collecting system. Thirty-six patients in the ethanol group received sclerotherapy with 95% ethanol and 36 patients in the HS group underwent sclerotherapy with 20% HS. The complete regression ratio of the ethanol group was significantly higher (94% versus 72%, respectively) than that of the HS group. There was one patient with partial regression in each group. The failure ratio of the ethanol group was significantly lower (3% versus 25%, respectively) than that of the HS group. CONCLUSION: Ethanol sclerotherapy under CT guidance is a successful and safe procedure and it can be used for the treatment of simple renal cysts. Sclerotherapy with 95% ethanol is more effective than 20% HS sclerotherapy. Sclerotherapy with HS may be an option for patients preferring to undergo a less painful treatment procedure. 相似文献
Objective: The purpose of this study was to examine the vasoreactivity in retina and choroid of the healthy eyes in response to experimentally altered partial arterial pressure of carbon dioxide (PaCO2) using a non-invasive technique, spectral domain optical coherence tomography (SD-OCT).Materials and methods: The study included non-smoking participants between 18 and 35 years of age, having visual acuity of 20/20 and with no systemic and ocular diseases. At baseline, the participants breathed room air (normocapnia). Hypocapnia was created with the help of hyperventilation; for this, the participants were instructed to draw deep and quick breaths, resulting one breathing cycle per 2?s. To create hypercapnia subjects rebreathed from a 5?l bag at least 3?min. Choroidal thickness and retinal artery diameter were measured at baseline, and hyperventilation and rebreathing conditions by SD-OCT.Results: Twenty eyes of 20 healthy subjects were included in this study. Their mean age was 24.90?±?5.32 years. Hyperventilation caused a significant reduction in choroidal thickness, compared with baseline, at all points; whereas rebreathing caused no significant change at all points. The mean diameters of the arteries were 151.80?±?7.88?μm, with a significant decline to 148.90?±?7.25?μm at hyperventilation condition and a significant increase to 153.50?±?7.88?μm at rebreathing condition (p?=?0.018, p?=?0.043, respectively).Conclusion: This study demonstrated that, SD-OCT was a useful tool in measuring the ocular vascular response under hypercapnia and hypocapnia conditions. These findings may be helpful for further understanding the physiological nature of ocular blood flow and this preliminary study provides a basis for future studies. 相似文献
Background: High-sensitivity cardiac troponin T (hs-cTNT) is an important non-invasive laboratory-based marker of subclinical myocardial injury. Prehypertension, which may be a precursor of hypertension, is a major public health issue. Our aim was to evaluate the importance of serum hs-cTnT as a marker predicting prehypertension.
Methods: A total of 100 subjects (45 women and 55 men) consisting of 50 consecutive prehypertensive patients with blood pressures between 120/80 and 139/89 mmHg and 50 normotensive patients with blood pressures < 120/80 mmHg were enrolled prospectively. The hs-cTNT level was calculated and compared between the two groups. Echocardiographic examinations were performed in all patients.
Results: The hs-cTnT level was significantly higher in the prehypertensive group (p < 0.001) and was positively correlated with prehypertension (r = 0.625, p < 0.001). Hs-cTnT was an independent predictor of prehypertension (odds ratio = 1.043, 95% confidence interval [CI] 1.019–1.067, p < 0.001). An Hs-cTnT level of 0.55 ng/L was predictive of prehypertension with a sensitivity of 86% and specificity of 60% (area under the curve = 0.861; 95% CI, 0.787–0.935; p < 0.001).
Conclusion: hs-cTnT may complement other diagnostic biomarkers in predicting prehypertension.
In the post-sternotomy mediastinitis patients, Staphylococcus
aureus is the pathogenic microorganism encountered most often.
In our study, we aimed to determine the efficacy of antibiotic treatment
with vancomycin and tigecycline, alone or in combination with hyperbaric
oxygen treatment, on bacterial elimination in experimental S. aureus
mediastinitis.
METHODS
Forty-nine adult female Wistar rats were used. They were randomly divided
into seven groups, as follows: non-contaminated, contaminated control,
vancomycin, tigecycline, hyperbaric oxygen, hyperbaric oxygen + vancomycin
and hyperbaric oxygen + tigecycline. The vancomycin rat group received 10
mg/kg/day of vancomycin twice a day through intramuscular injection. The
tigecycline group rats received 7 mg/kg/day of tigecycline twice a day
through intraperitoneal injection. The hyperbaric oxygen group underwent 90
min sessions of 100% oxygen at 2.5 atm pressure. Treatment continued for 7
days. Twelve hours after the end of treatment, tissue samples were obtained
from the upper part of the sternum for bacterial count assessment.
RESULTS
When the quantitative bacterial counts of the untreated contaminated group
were compared with those of the treated groups, a significant decrease was
observed. However, comparing the antibiotic groups with the same antibiotic
combined with hyperbaric oxygen, there was a significant reduction in
microorganisms identified (P<0.05). Comparing hyperbaric
oxygen used alone with the vancomycin and tigecycline groups, it was seen
that the effect was not significant (P<0.05).
CONCLUSION
We believe that the combination of hyperbaric oxygen with antibiotics had a
significant effect on mediastinitis resulting from methicillin-resistant
Staphylococcus aureus. Methicillin-resistant
Staphylococcus aureus mediastinitis can be treated
without requiring a multidrug combination, thereby reducing the medication
dose and concomitantly decreasing the side effects. 相似文献