全文获取类型
收费全文 | 3710篇 |
免费 | 180篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 22篇 |
儿科学 | 88篇 |
妇产科学 | 22篇 |
基础医学 | 512篇 |
口腔科学 | 88篇 |
临床医学 | 259篇 |
内科学 | 1059篇 |
皮肤病学 | 90篇 |
神经病学 | 216篇 |
特种医学 | 144篇 |
外科学 | 509篇 |
综合类 | 17篇 |
预防医学 | 59篇 |
眼科学 | 78篇 |
药学 | 205篇 |
中国医学 | 10篇 |
肿瘤学 | 533篇 |
出版年
2024年 | 5篇 |
2023年 | 39篇 |
2022年 | 85篇 |
2021年 | 147篇 |
2020年 | 65篇 |
2019年 | 93篇 |
2018年 | 101篇 |
2017年 | 82篇 |
2016年 | 117篇 |
2015年 | 108篇 |
2014年 | 129篇 |
2013年 | 172篇 |
2012年 | 245篇 |
2011年 | 247篇 |
2010年 | 171篇 |
2009年 | 116篇 |
2008年 | 210篇 |
2007年 | 219篇 |
2006年 | 205篇 |
2005年 | 210篇 |
2004年 | 190篇 |
2003年 | 173篇 |
2002年 | 198篇 |
2001年 | 50篇 |
2000年 | 44篇 |
1999年 | 47篇 |
1998年 | 45篇 |
1997年 | 46篇 |
1996年 | 39篇 |
1995年 | 24篇 |
1994年 | 31篇 |
1993年 | 26篇 |
1992年 | 24篇 |
1991年 | 26篇 |
1990年 | 21篇 |
1989年 | 24篇 |
1988年 | 10篇 |
1987年 | 17篇 |
1986年 | 11篇 |
1985年 | 13篇 |
1984年 | 8篇 |
1983年 | 11篇 |
1980年 | 9篇 |
1979年 | 7篇 |
1978年 | 6篇 |
1977年 | 4篇 |
1976年 | 5篇 |
1975年 | 4篇 |
1974年 | 5篇 |
1973年 | 4篇 |
排序方式: 共有3911条查询结果,搜索用时 0 毫秒
1.
2.
3.
Kunihiro Ichinose Mitsuru Nakamura Kenji Takezawa Ichiro Masutomi Yoichi Shima Yoko Hirayama Kahoko Sorimachi Teruhiko Shimizu Hiroyo Ishikawa Namiko Kaji Sayaka Nakajima Michiko Wataru Shiho Nishigaki Hiroshi Suwa Yosuke Toyama Masaki Okumura Yoshikazu Ishitsuka Ken Shimizu Kazuya Kokubo Kenji Sasaki Shodai Saito 《Seishin shinkeigaku zasshi》2006,108(9):945-954
4.
Yutaka Ejima Yoko Hasegawa Satoru Sanada Noriyuki Miyama Ryo Hatano Tomohiro Arata Michiko Suzuki Itsuro Kazama Akira Sato Susumu Satomi Wataru Hida Mitsunobu Matsubara 《Hypertension research》2006,29(4):261-267
Since the prevalence and clinical characteristics of young-onset hypertension are still to be elucidated, we performed targeted-screening at an annual university health check-up for two consecutive years. Out of 16,464 subjects in 2003 and 17,032 in 2004 that were aged less than 30 years, 22 and 26 students (all males) exhibited high blood pressure (BP), respectively, on three occasions during casual BP measurements at the Tohoku University Health Center (systolic and diastolic BP of 140 and/or 90 mmHg or greater, respectively). These students were asked to measure their BP at home, and 9 subjects in total were diagnosed as having essential hypertension (EH). The remaining students were diagnosed as having white coat hypertension (WCH). In 8 out of 9 EH students, their father and/or mother had also been treated with antihypertensive medication. Adjustment by attendance ratio for each BP measurement suggested that the incidence of EH was around 0.1% and that of hypertension (EH and WCH) was around 0.5% in university students aged less than 25 years, since most of the subjects and hypertensive students were between 18 and 24 years old. Body mass index of the EH, which was more than 25 kg/m2 (overweight), was significantly higher than that with WCH. In conclusion, the combination of repeated casual BP measurements and home BP effectively identified young-onset EH. The clinical parameters indicated that male gender, genetic background, and excessive weight were risk factors for young-onset hypertension. 相似文献
5.
M Higashigawa Y Komada N Washio H Kuwabara H Hori M Ido M Sakurai 《Leukemia research》1992,16(10):1049-1054
In vitro preincubation with recombinant granulocyte colony-stimulating factor(rhG-CSF, 100 ng/ml) enhanced the cytotoxicity of 1-beta-D-arabinofuranosylcytosine(Ara-C) in leukemic cells resistant to Ara-C from a patient with biphenotypic leukemia. Treatment of the cells with rhG-CSF resulted in a 17-fold increase in DNA synthesis, 4.6-fold increase in percentage of S-phase, and a two-fold increase in Ara-CTP formation. Maximal effect was observed at 72 h of incubation. Combination chemotherapy with rhG-CSF and Ara-C to the patient showed remarkable cytoreduction. These results indicate that recruitment of resistant leukemic cells in cell kinetic quiescence is inducible by rhG-CSF and that it is possible enhancement of the cytotoxicity to cell cycle-specific drugs such as Ara-C. 相似文献
6.
Wataru Kimura 《Journal of hepato-biliary-pancreatic sciences》2003,10(2):156-162
The differences and similarities between intraductal papillary mucinous tumor (IPMT) and mucinous cystadenoma or carcinoma (mucinous cystic tumor; MCT) of the pancreas have been noted. The similarities include: (1) both tumors originate from pancreatic duct cells, (2) massive mucin production is found in both tumors, and (3) papillary projection is a common histological characteristic. However, there are also many differences. IPMT is most frequently found in men in their sixties, and originates in the head of the pancreas, with 62% (123/199) of tumors reported to be found in the head of the pancreas. This tumor sometimes spreads throughout the entire pancreas. The tumor itself basically is of the dilated pancreatic duct type, and the prognosis is generally good. In contrast, MCT frequently develops in women in their forties. This tumor is usually large, round, and almost totally encapsulated by fibrous tissue, with no communication with the pancreatic duct. The tumor histologically has an ovarian-like stroma. It most often develops in the body or tail of the pancreas. Invasion is often present and the operative prognosis is not good. IPMT resembles the shape of a bunch of grapes and MCT resembles that of an orange. From the differences between these two types of tumors, they are classified into different categories. With regard to therapeutic strategies for MCT, the tumor should be resected with lymph node dissection immediately when it is detected. In contrast, some patients with branch-type IPMT can be followed without surgical procedures. Because IPMT shows good prognosis and little tendency for infiltration, some kinds of organ-preserving procedures would be possible for some patients with this tumor. Such organ-preserving procedures are: duodenum-preserving pancreas head resection, spleen-preserving distal pancreatectomy with conservation of the splenic artery and vein, and so on. 相似文献
7.
Tomohiro Kondo Kazuhiro Sentani Naohide Oue Kazuhiro Yoshida Hirofumi Nakayama Wataru Yasui 《Pathobiology》2004,71(1):19-25
OBJECTIVES: RHOC, a member of the RAS-related small GTPase protein family, regulates cytoskeletal structures and has the potential to transform cultured cells. It has recently been reported that RHOC contributes to the metastatic phenotype of melanoma cells. The purpose of this study was to clarify its biological relevance to gastric carcinogenesis and metastasis. METHODS: We examined the expression of RHOC by quantitative RT-PCR in 51 cases of gastric carcinoma tissues from prior surgical cases (intestinal type: 24 cases, diffuse type: 27 cases) and in 8 gastric carcinoma cell lines. RESULTS: RHOC expression levels in primary tumors were significantly higher in cases with metastasis than in those without metastasis (p = 0.0202; Mann-Whitney U test). RHOC expression levels in primary tumor and their metastatic tumors were significantly higher than their corresponding nonneoplastic mucosa (p = 0.0357, and 0.0173, respectively; Wilcoxon signed rank test). RHOC mRNA expression was confirmed in the gastric carcinoma cell lines. CONCLUSION: Our findings suggest that elevated expression of the RHOC gene may be involved in the metastasis of gastric carcinomas and may be a good genetic marker for the prediction of a metastatic potential. 相似文献
8.
Y Komada H Yamamoto E Azuma S Tanaka H Kamiya M Sakurai 《Biomedicine & Pharmacotherapy》1988,42(10):669-673
The sera from 55 children with acute lymphoblastic leukemia (ALL) treated with active immunotherapy were examined for the presence of antibodies against common ALL antigen (CALLA). A solid phase indirect radioimmunometric assay (IRA) was developed which enabled the detection of anti-CALLA antibody in patients' sera, utilizing the ability of affinity-purified CALLA to bind Ricinus communis agglutinin and anti-CALLA antibody simultaneously. Using IRA, anti-CALLA antibody activity could not be detected in a majority of patients. We concluded that the patients did not raise comparable antibodies against CALLA, indicating this antigen is not immunogenic for ALL patients. 相似文献
9.
3D kinematic analysis of the acromioclavicular joint during arm abduction using vertically open MRI.
Wataru Sahara Kazuomi Sugamoto Masakazu Murai Hiroyuki Tanaka Hideki Yoshikawa 《Journal of orthopaedic research》2006,24(9):1823-1831
Many researchers have evaluated the motions of the shoulder girdle, especially scapular and humeral motion. However, few reports exist that describe motions of the acromioclavicular joint. The purpose of the present study was to analyze the 3D kinematics of the acromioclavicular joint during arm abduction using 3D MR images obtained by a vertically open MRI. Fourteen shoulders of seven volunteers were examined in seven static positions from 0 degrees to the maximum abduction in a seated position. 3D surface models of the clavicle and scapula were created, and the movements of the acromioclavicular joint from 0 degrees to each position were calculated using the volume-based registration technique. From these calculations, the translations were evaluated and the rotational motions were analyzed using the concept of the screw axis. In the anteroposterior direction, the clavicle translated most posteriorly (-1.9 +/- 1.3 mm) at 90 degrees of abduction and most anteriorly (1.6 +/- 2.7 mm) at maximum abduction. In the superoinferior direction, the clavicle translated slightly superiorly (0.9 +/- 1.9 mm). When analyzing relative motion of the scapula with respect to the clavicle, the scapula generally rotated about a specific screw axis passing through the insertions of both the acromioclavicular and the coracoclavicular ligaments on the coracoid process. The average rotation was 34.9 +/- 8.4 degrees. 相似文献
10.
Masashi Watanabe Haruhiro Nakazaki Natsuki Tokura Wataru Takita Kazuo Kobayashi 《Journal of hepato-biliary-pancreatic sciences》2004,11(6):422-425
Hemosuccus pancreaticus (HP) is a rare cause of gastrointestinal bleeding, usually due to rupture of a visceral artery aneurysm in chronic pancreatitis. Other causes of HP are rare. We present a case of HP which occurred in a patient with chronic calcifying pancreatitis and a pancreatic pseudocyst documented by ultrasonography and computed tomography. With detectable fresh blood in the descending duodenum, an aneurysm in the pancreatic head was revealed by superior mesenteric angiography as the suspected origin of intermittent bleeding from the pancreatic duct. Because an artery feeding the pseudocyst could not be identified, angiographic embolization was not possible. Surgical resection or ligation was difficult by laparotomy; therefore, intraoperative packing of the pseudocyst with absorbable gelatin sponges was achieved via a cannula through a directly punctured site in the pseudocyst wall. The patient has been followed for 4.25 years with no further episodes of HP. It is possible that the packing of a pancreatic pseudocyst with gelatin sponges is a method that can be used in similar cases, where control of hemostasis is the primary concern. The packing of a pancreatic pseudocyst with gelatin sponges is a technique that can be performed not only via laparotomy but also via laparoscopy or concomitant angiography and ultrasonography. 相似文献