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The first 150 words of the full text of this article appear below. Key points Coronary artery disease accounts for >30% ofdeaths in Western society. The diagnosis of myocardial infarctionshould be qualified by size, causation and time from occurrence. Mortalityis reduced by immediate or primary percutaneouscoronary intervention or thrombolysis within the first 24 hof onset of ST-segment elevation myocardial infarction. Strategiesto reduce platelet activation (glycoprotein IIb/IIIa receptorantagonists, or clopidogrel) are now recommended in the treatmentof high-risk non-ST-segment myocardial infarction/unstable angina. Elevatedserum troponins may be the result of non-ischaemic myocardialdamage, especially in critical illness.
Pathophysiology
Changes in the definition of terms relating to the diagnosisof myocardial infarction (MI) have evolved by better understandingof the pathophysiology culminating in the new term of acutecoronary syndrome (ACS). Figure 1 illustrates the processesthat occur in the development of an acute coronary event. 相似文献
3.
In the first years of its use, operative laparoscopy for uterine pathology was employed in the surgical treatment of myomas and in the correction of uterine retroversion (hysteropexy). More recently the technique has been employed for the laparoscopically assisted hysterectomy or for subtotal laparoscopical hysterectomy using the Semm Kit. Also radical hysterectomy has been performed in advanced centers by laparoscopy. In this paper, the Authors discuss the indications, the counterindications, the risks and complications of the operative laparoscopy in the different forms of ovarian pathology. 相似文献
4.
J A Papadakis D Trichopoulos N Papaiconomou D Karalis P Vassiliadis 《Bulletin de la Societe de pathologie exotique (1990)》1975,68(2):151-152
A new Salmonella serotype, of sub-genus II, Salmonella 3,10 : 1,z28 : 1.5, has been isolated in Greece from refrigerated minced meat imported from South America. 相似文献
5.
Short-term therapy for recurrent abortion using intravenous immunoglobulins: results of a double-blind placebo-controlled Italian study 总被引:1,自引:3,他引:1
Perino A; Vassiliadis A; Vucetich A; Colacurci N; Menato G; Cignitti M; Semprini AE 《Human reproduction (Oxford, England)》1997,12(11):2388-2392
It is still unclear whether i.v. immunoglobulins (Ig) can facilitate the
reproductive prognosis of women who have suffered recurrent pregnancy loss.
We report the results of a multicentre placebo- controlled study on the
effect of Ig administration on pregnancy outcome in 46 women who had
suffered at least three recurrent miscarriages. All were screened to
exclude chromosomal or Mullerian abnormalities, the presence of antinuclear
antibodies, lupus anticoagulant (LA) or elevated titres of anticardiolipin
antibodies which may have revealed an underlying autoimmune problem. To
avoid a selection bias towards ongoing pregnancies, i.v. Ig or placebo were
administered between weeks 5 and 7 of gestation for 2 consecutive days as
soon as each woman knew she was pregnant and before embryonic heart
activity could be detected. A further infusion was administered at week 8
when ultrasonography confirmed an ongoing embryonic development. In all,
68% of the women who received Ig went to term versus 79% of those who
received a placebo (not significant), with no significant differences in
the pregnancy course or the perinatal outcome. These results suggest either
that women with recurrent miscarriages who have no recognized cause of
pregnancy loss have a good reproductive prognosis without any treatment or
that the emotional care associated with the administration of a placebo can
indirectly facilitate the progression of pregnancy.
相似文献
6.
Athanassakis I Papadimitriou L Bouris G Vassiliadis S 《Developmental and comparative immunology》2000,24(6-7):663-672
Maturation of the murine ectoplacental cone results in the development of the placental tissue which essentially consists of two trophoblastic zones, the spongiotrophoblast and labyrinthine trophoblast. In this study we attempted to investigate the action of cytokines on ectoplacental cone cell differentiation to mature trophoblast cells. After determining the cellular composition of the ectoplacental cone cell suspensions based on the expression of cytokeratin, vimentin, Mac-1, class I and class II MHC antigens, the cells were exposed to the differentiation-inducing cytokines IL-3, GM-CSF, CSF-1 and IFN-gamma. From the four factors employed, only IFN-gamma increased the levels of cytokeratin-positive cells without inducing Mac-1 expression. IL-3 increased the percentages of cytokeratin as well as Mac-1- and vimentin-positive cells whereas GM-CSF and CSF-1 preferentially promoted an increase of the Mac-1 and vimentin markers. For further analysis, ectoplacental cone cells were negatively selected for Mac-1, class I and class II antigens to exclude non-trophoblastic contaminants and thereafter treated with the same cytokines. We show here that only IFN-gamma leads the sorted ectoplacental cone cells to a pure trophoblastic population composed of 100% cytokeratin-positive cells. The specificity of IFN-gamma on this differentiation pathway is strengthened by the fact that murine maternal serum on the day of EC formation contains high levels of this cytokine, suggesting that its natural presence supports - at least phenotypically - the in vivo differentiation of EC cells to trophoblasts. 相似文献
7.
Yanfang Li Menda LP Qiuliang WU Fuyuan Liu Jundong Li Jinglin Zou Yongwen Huang 《中国肿瘤临床(英文版)》2004,1(3):180-184
Objective Ovarian dysgerminoma is an uncommon ovarian malignancy, Its clinicai features are special and there are many factors affecting
its prognosis. If treated properly, the patient can be cured. Otherwise it may endanger the patient’s life. The aim of this
study is to investigate the clinical features and factors related to prognosis of ovarian dysgerminoma.
Methods Data from 57 patients with pure ovarian dysgerminoma were analyzed retrospectively. The patients were admitted to the Cancer
Center, Sun Yat-sen University from January 1.1964 to December 31, 2000.
Results The main clinical features were abdominal mass (56.1% ), abdominal pain (21.1% ), abdominal swelling (17.5%.), vaginal bleeding
(5.3% )and genital tract abnormalities (5.3%). Twenty-six patients had stage I diseases, 8 stage II.9 stage III.1 stage IV
and 13 recurrent and persistent diseases. The uterus was involved in 41.2% of patients with stage II -III diseases. Combined
modality was given to 52 cases and a single-method treatment to 5 cases. The total overall 5 and 10-year survival rates for
stages I-IV was 80.1 % and 70.0% respectively. The 5-year survival rate for stage I was 100%, stage II 55.2%. stage III 55.6%
and stage IV 0%; for recurrent and persistent diseases, 72.7%. The stage I group of 12 patients. received adnexectomy and
14 patients underwent hysterectomy and adnexa removal. There was no significant difference between the 5 and 10-year survival
rates (all 100%). Of the 23 patients in the stage I group to whom oniy chemotherapy was given after operation, 19 cases received
3 or more courses and were well without recurrence; 4 patients received only one course and one of them recurred 21 months
after the operation. In the group of stages II and III cases, the 5-year survival rate was 86.7% for those whose chemotherapy
courses were 3≥ 4 and 25.0% for patients who received less than 4 courses of chemotherapy (P<0.05).
Conclusions The prognosis of ovarian dysgerminoma is closely related to the disease stage and treatment modality. A fertility-preserving
operation can be considered in early -staged patients, but caution needs to be exercised in the middle to late staged cases.
Good results can be achieved with an operation-based combined modality in recurrent patients. 相似文献
8.
灯盏花素对豚鼠单一心室肌细胞ICa的抑制作用 总被引:25,自引:0,他引:25
目的:观察灯盏花素对豚鼠单一心室肌细胞钙离子电流(ICa)的影响。方法:应用全细胞膜片钳制技术。结果:灯盏花素能明显抑制心室肌细胞的Ca^2+通道,使ICa减小。此作用有明显的电压依赖性。在峰电流电压下作用最明显,而对其反转电位无明显影响。在指令电位0mV时,0.5mg%灯盏花素使ICa减小5.4%,1mg%灯盏花素使ICa减小22.9%(P〈0.01),2mg%灯盏花素使ICa减小45.0%(P 相似文献
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