Persian version of the geriatric anxiety scale: Translation and preliminary psychometric properties among Iranian older adults

Objective: The Geriatric Anxiety Scale (GAS) is a new self-report screening measure designed for older adults. Due to the burgeoning Iranian population of older adults and the need for validated, culturally-appropriate screening measures for anxiety in Iran, the purposes of the present study were to translate the GAS into Persian and to explore its preliminary psychometric properties.

Method: Iranian older adults (N = 295; M age = 67.0 years) completed the GAS and the Iranian version of the Geriatric Depression Scale (GDS-15).

Results: Cronbach's alpha for the GAS total score and the GAS subscales were excellent (Total score α = .92; Cognitive α = .81; Somatic α = .84; Affective α = .80). As expected, each subscale was significantly positively correlated (all p's < .01) with the other subscales. The subscales share common variance ranging from 42% to 56%. The GAS total score and GAS subscale scores were significantly positively correlated with the GDS-15, with medium effect sizes (GAS Total r = .55; Cognitive r = .51; Somatic r = .50; Affective r = .48). Finally, exploratory and confirmatory factor analyses were conducted to investigate the factor structure of the Persian version of the GAS. Results support a one factor solution (general anxiety) for this Iranian sample.

Conclusion: This study provides preliminary psychometric support for the Persian version of the GAS as a screening measure for anxiety in Iranian older adults, with a one-dimensional factor structure.     

Using memory restructuring strategy to enhance dental behaviour

AIMS: This study sought to 'restructure' memory of dental treatment to help children develop positive memories and cooperate more fully with the dentist at future visits. DESIGN: The design compared 'usual care' plus an intervention designed to positively restructure memory with 'usual care' plus a control for 45 children, ages 6-9 years, who were in need of two restorative treatment visits. The intervention occurred at the second visit immediately before the dental treatment and focused on restructuring the child's memory of the first treatment visit. Children were asked to recall how much fear and pain they experienced during the first dental treatment. RESULTS: The child's behaviour improved from the first dental treatment visit to the second in the intervention group but not in the control condition. When compared to the controls, those in the intervention group changed their memory of the fear they experienced at the first treatment and their memory of experienced pain. CONCLUSIONS: Restructuring memory may be effective in reducing fear for future treatment, and is easily adaptable to clinical practice in other healthcare situations.     

Targeting adenovirus to the serotype 3 receptor increases gene transfer efficiency to ovarian cancer cells.

Gene delivery efficiency in clinical cancer gene therapy trials with recombinant adenoviruses (Ads) based on serotype 5 (Ad5) has been limited partly because of variable expression of the primary Ad5 receptor, the coxsackie and adenovirus receptor (CAR), on human primary cancer cells. As a means of circumventing CAR deficiency, Ad vectors have been retargeted by creating chimeric fibers possessing knob domains of alternate Ad serotypes. In this study, we have constructed an Ad5-based vector, Ad5/3luc1, with a chimeric fiber protein featuring a knob domain derived from Ad3. This virus is retargeted to the Ad3 receptor and, therefore, has different tissue tropism. A novel knob binding assay was used to measure expression of CAR and the Ad3 receptor. Further, to evaluate the correlation of receptor expression and infectivity by Ad, a panel of ovarian cancer cell lines and purified primary cancer cells were infected with Ad5luc1 and Ad5/3luc1 at 50, 200, and 1000 viral particles/cell. Our results confirm that Ad5/3luc1 is retargeted to the Ad3 receptor. Furthermore, the Ad3 receptor is present at higher levels than CAR on ovarian adenocarcinoma cells. Also, the amount of binding to primary receptor appears to be the major factor determining the efficiency of transgene expression. The Ad5/3 chimera displays enhanced infectivity for ovarian cancer cell lines and purified primary tumor cells, which could translate into increased efficacy in clinical trials.     

Preliminary psychometric properties of a measure of Karen Horney's Tridimensional theory in children and adolescents

This study established the psychometric properties of a child and adolescent version of the Horney-Coolidge Tridimensional Inventory (HCTI), which assesses psychoanalyst Karen Horney's theory of neurotic types. Parents of 302 children (ages 5 to 17 years; median age = 12.0 years) completed the new 45-item version of the HCTI and the Coolidge Personality and Neuropsychological Inventory (CPNI) about their children. The three main scales (Compliance, Aggression, and Detachment) had good internal scale reliability and excellent test-retest reliability. Principal components analysis supported Horney's three dimensions and a six-component substructure. There was also sufficient construct validity with personality disorder scales from the CPNI with the three HCTI dimensions and their six components. The implications of the findings are discussed for Horneyan theory.     

Psychological and Neurobehavioral Comparisons of Children with Asperger’s Disorder Versus High-Functioning Autism

This study investigated personality and neurobehavioral differences between 16 children with Asperger’s Disorder, 15 children with High-Functioning Autism (HFA), and 31 controls, all ranging in age from 5–17 years, M age = 10.7 years, SD = 3.0. Parents rated their children’s behaviors on a 44-item autistic symptoms survey and on the 200-item Coolidge Personality and Neuropsychological Inventory (Coolidge, Thede, Stewart, & Segal (2002a). The Coolidge Personality and Neuropsychological Inventory for Children (CPNI): Preliminary psychometric characteristics. Behavior Modification, 26, 550–566). The results indicated that the two clinical samples were significantly elevated on the Executive Function Deficits scale and Attention-Deficit/Hyperactivity Disorder (ADHD) scale compared to controls. There were more similarities than differences between the two clinical samples on the personality scales, although the Asperger’s group scored significantly on the two scales with anxiety components.     

The Dental Neglect Scale in adolescents

Background  

Dental neglect has been found to be related to poor oral health, a tendency not to have had routine check-ups, and a longer period of time since the last dental appointment in samples of children and adults. The Dental Neglect Scale (DNS) has been found to be a valid measure of dental neglect in samples of children and adults, and may be valid for adolescents as well. We administered the DNS to a sample of adolescents and report on the relationships between the DNS and oral health status, whether or not the adolescent has been to the dentist recently for routine check-ups, and whether or not the adolescent currently goes to a dentist. We also report the internal and test-retest reliabilities of the DNS in this sample, as well as the results of an exploratory factor analysis.     

Comparison of a parent-rated DSM-IV measure of attention-deficit/hyperactivity disorder and quantitative EEG parameters in an outpatient sample of children.

Attention-deficit/hyperactivity disorder (ADHD) was investigated using the parent-as-respondent, 200-item, Coolidge Personality and Neuropsychology Inventory (CPNI) and a quantitative electroencephalograph (QEEG). Parents of 183 children (mean age = 12.2 years) brought to an outpatient private clinic for behavioral and/or emotional problems completed the CPNI including the 18-item DSM-IV-based ADHD scale and their children were also evaluated by QEEG. The correlation between the CPNI ADHD scale T score and the categorical QEEG parameter (based on the beta-theta power ratio) for the identification of ADHD was r = -0.15. Using a dichotomous ADHD CPNI measure (positive/negative) and the QEEG beta-theta power ratio resulted in an r value of -0.09. The sensitivity of the QEEG ADHD parameter and the CPNI ADHD scale was 50% and the specificity was 36%. The results stand in contrast to those of who found 90% sensitivity and 94% specificity between behavioral measures of ADHD and the QEEG scanning procedure. The lack of correspondence between the two measures is discussed.     

Relationships among depressive,passive-aggressive,sadistic and self-defeating personality disorder features with suicidal ideation and reasons for living among older adults

Objectives: Suicide among older adults is a major public health problem in the USA. In our recent study, we examined relationships between the 10 standard DSM-5 personality disorders (PDs) and suicidal ideation, and found that the PD dimensions explained a majority (55%) of the variance in suicidal ideation. To extend this line of research, the purpose of the present follow-up study was to explore relationships between the four PDs that previously were included in prior versions of the DSM (depressive, passive-aggressive, sadistic, and self-defeating) with suicidal ideation and reasons for living.

Method: Community-dwelling older adults (N = 109; age range = 60–95 years; 61% women; 88% European-American) completed anonymously the Coolidge Axis II Inventory, the Reasons for Living Inventory (RFL), and the Geriatric Suicide Ideation Scale (GSIS).

Results: Correlational analyses revealed that simple relationships between PD scales with GSIS subscales were generally stronger than with RFL subscales. Regarding GSIS subscales, all four PD scales had medium-to-large positive relationships, with the exception of sadistic PD traits, which was unrelated to the death ideation subscale. Multiple regression analyses showed that the amount of explained variance for the GSIS (48%) was higher than for the RFL (11%), and this finding was attributable to the high predictive power of depressive PD.

Conclusion: These findings suggest that depressive PD features are strongly related to increased suicidal thinking and lowered resilience to suicide among older adults. Assessment of depressive PD features should also be especially included in the assessment of later-life suicidal risk.     

Marital Satisfaction and Personality Traits in Long-Term Marriages: An Exploratory Study

This study explored personality dimensions that contribute to marital satisfaction in older couples in long-term marriages (M = 49.2 years). Each spouse completed the Comprehensive Marital Satisfaction Scale, the Horney-Coolidge Tridimensional Inventory (HCTI), and the NEO-Five Factor Inventory (NEO-FFI). There was a moderate correlation between the marital satisfaction scores for husbands and wives. Husbands' marital satisfaction was significantly higher when their self-reported HCTI Detachment scores were lower and their HCTI Aggression scores were higher. Wives' marital satisfaction was higher when their Detachment scores and their husbands' Detachment scores were lower. On the NEO-FFI, only wives' marital satisfaction was significantly related to the more Extraverted and the less Conscientious the husbands reported themselves to be. Clinical implications and research directions are discussed.