全文获取类型
收费全文 | 367篇 |
免费 | 14篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 20篇 |
妇产科学 | 5篇 |
基础医学 | 27篇 |
口腔科学 | 25篇 |
临床医学 | 22篇 |
内科学 | 51篇 |
皮肤病学 | 27篇 |
神经病学 | 12篇 |
特种医学 | 16篇 |
外科学 | 137篇 |
综合类 | 7篇 |
预防医学 | 1篇 |
眼科学 | 1篇 |
药学 | 8篇 |
中国医学 | 2篇 |
肿瘤学 | 17篇 |
出版年
2023年 | 4篇 |
2022年 | 12篇 |
2021年 | 11篇 |
2020年 | 8篇 |
2019年 | 4篇 |
2018年 | 7篇 |
2017年 | 4篇 |
2016年 | 15篇 |
2015年 | 16篇 |
2014年 | 18篇 |
2013年 | 17篇 |
2012年 | 20篇 |
2011年 | 22篇 |
2010年 | 21篇 |
2009年 | 25篇 |
2008年 | 28篇 |
2007年 | 34篇 |
2006年 | 24篇 |
2005年 | 21篇 |
2004年 | 14篇 |
2003年 | 18篇 |
2002年 | 21篇 |
2001年 | 2篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1998年 | 6篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1994年 | 3篇 |
1993年 | 1篇 |
1981年 | 1篇 |
1974年 | 1篇 |
排序方式: 共有383条查询结果,搜索用时 15 毫秒
1.
2.
Erhan Firatli Tahsin Ünal Nurcin Saka Utku Onan Ahmet Sivas Hikmet Öz 《Journal of clinical periodontology》1994,21(8):565-568
Abstract Fructosamine assay, which is used in diagnosing and monitoring diabetic patients, is compared with the hemoglobin and plasma glucose assays in children and adolescent insulin-dependent diabetes mellitus patients. We demonstrated that the gingival index scores were correlated with fructosamine values in insulin-dependent diabetes mellitus patients but not in non-diabetic controls. We also found that there was no correlation between gingivitis scores and fasting plasma glucose and HbAlc values. Periodontitis was found to be rare in diabetic children and adolescents. 相似文献
3.
Acar H Kaynak M Yakut T Uçar F Egeli U 《Teratogenesis, carcinogenesis, and mutagenesis》2002,22(5):369-375
We have used the single and dual color fluorescence in situ hybridization (FISH) technique combined with a new detection system, tyramide signal amplification (TSA), by using the multiple endocrine neoplasm type 1 (MEN1) gene and chromosome 11 specific alpha satellite DNA probes for the study of the allelic deletion of the MEN1 gene. The MEN1 gene is a new tumor suppressor gene and has been recently cloned on chromosome 11q13. FISH combined with the TSA detection system was performed on bone marrow interphase nuclei of 22 patients with acute myeloid leukemia (AML). The FISH-TSA analysis revealed the mono allelic deletion of the MEN1 gene in 4 out of 22 patients (18.18%), 2 of 9 AML-M2 patients (22.2%), 1 of 6 AML-M4 patients (16.6%), and 1 of 4 AML-M5 patients (25.0%). Our study indicates that allelic deletion of the MEN1 gene is not a major cause or a primary event in tumorigenesis of AML, although the long arm (q13 region) of chromosome 11 involves a chromosomal rearrangement in AML. 相似文献
4.
5.
Battal Tahsin Somuk Sema Koc Omer Ates Göksel Göktas Harun Soyalic Ismail Onder Uysal 《Acta oto-laryngologica》2016,136(11):1168-1172
Conclusion: A significant association was found of oropharyngeal tularemia with SLC11A1 allele polymorphism (INT4?G/C) and MBL2 C?+?4T (P/Q). These results indicate C allele and Q allele might be a risk factor for the development of oropharyngeal tularemia.Aim: This study aimed to investigate the relationship of SLC11A1, MBL, and P2X7 gene polymorphism with oropharyngeal tularemia.Methods: The study included totally 120 patients who were diagnosed with oropharyngeal tularemia. Frequencies of polymorphisms in the following genes were analyzed both in the patient and control groups in the study: SLC11A1 (5’(GT)n Allele 2/3, Int4?G/C, 3’ UTR, D543N G/A), MBL (MBL2 C?+?4T (P/Q), and P2X7 (?762 C/T and 1513 A/C).Results: Among all polymorphisms that were investigated in this study, SLC11A1 gene showed a significance in the distriburtion of polymorphism allelle frequency at the INT4 region. Frequency of C allele was 54 (28%) in patients with oropharyngeal tularemia, and 31 (13%) in the control group (p?=?0.006 and OR = 1.96 (1.21–3.20)). An association was detected between MBL2 C?+?4T (P/Q) gene polymorphism and oropharyngeal tularemia (p?0.005 and OR?=?0.30 (0.19–0.48)). No significant relation was found between P2X7 (?762 C/T and 1513 A/C) gene polymorphism and oropharyngeal tularemia in this study (p?>?0.05). 相似文献
6.
Pınar Eroğlu Esra Erkol İnal Şebnem Özemri Sağ Özlem Görükmez Ali Topak Tahsin Yakut 《Clinical rheumatology》2016,35(5):1245-1251
Oxidative stress was related with carpal tunnel syndrome (CTS). We aimed to clarify the associations between glutathione S-transferase (GST)M1, GSTT1 and GSTP1-Ile105Val polymorphisms and CTS. One hundred-forty patients with CTS and 97 healthy controls were enrolled in this study. Tinel and Phalen signs were noted as positive or negative. Functional and clinical status of patients was evaluated by the Boston Questionnaire. The intensity of hand and/or wrist pain was evaluated on 10 cm visual analog scale (VAS). We applied the polymerase chain reaction (PCR) to determine the polymorphisms of the GSTM1 and GSTT1 and the PCR-restriction fragment length polymorphism method for detecting the GSTP1-Ile105Val polymorphism. The M1 null genotype was significantly higher in patients with CTS compared to healthy controls, and the M1 null genotype seemed to increase the risk of CTS approximately two-fold (P?=?0.011; odds ratio (OR)?=?1.98; 95 % confidence interval (CI) 1.17–3.36). The M1 null, T1 present combined genotype was significantly higher in patients with CTS compared to healthy controls (P?=?0.043); however, it seemed not to increase the risk of CTS (P?=?0.14; OR?=?0.62; 95 % CI 0.33–1.76). We found significantly higher levels of the VAS, Boston Symptom Severity Scale and Phalen sign in patients with the Ile/Val or the Val/Val genotypes compared to those in patients with the Ile/Ile genotype (P?=?0.003, 0.004 and 0.044, respectively). We proposed that genes involved in the protection from oxidative stress may influence the susceptibility, clinical and functional status of CTS. The GSTM1 null genotype may be related with the development of CTS, whereas the Val allele of GSTP1-Ile105Val polymorphism may be associated with worse functional and clinical status in CTS. 相似文献
7.
Eroglu Didem Sahin Torgutalp Murat Baysal Serdar Colaklar Anil Sezer Serdar Yayla Mucteba Enes Uzun Caglar Turgay Tahsin Murat Kinikli Gulay Ates Askin 《Clinical rheumatology》2021,40(10):4127-4134
Clinical Rheumatology - To report the clinical characteristics of pulmonary artery involvement (PAI) in patients with Behçet’s syndrome (BS) and to define the predictors of relapses. We... 相似文献
8.
Tuba Kara Ebru Serinsoz Rabia Bozdogan Arpaci Ozlem Gubur Gulhan Orekici Alper Ata Tahsin Colak Ali Arican 《Pathology, research and practice》2013
Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract, and the majority contain KIT or PDGFRA-activating mutations. However, up to 10% of GISTs are c-kit-negative. Antibodies with increased sensitivity and specificity for the detection of c-kit-negative GIST cases may be of value, especially because some of these cases may also benefit from tyrosine kinase inhibitor therapy. 相似文献
9.
Intraoral reconstruction with “thinned” peroneal artery perforator flaps: An alternative to classic donor areas in comorbid patients
下载免费PDF全文
![点击此处可从《Microsurgery》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Tahsin Oğuz Acartürk M.D. Andrés A. Maldonado M.D. Ph.D. Alex Ereso M.D. 《Microsurgery》2015,35(5):399-402
Free fasciocutaneous flaps like the radial forearm free flap (RFFF) and the anterolateral thigh (ALT) are the most commonly used flaps in intraoral reconstruction. However, certain conditions preclude the use of either of these flaps. The aim of this report was to show applicability of “thinned” peroneal artery perforator (PAP) flaps in intraoral reconstruction. We report two cases of squamous cell carcinoma involving the tongue and floor of the mouth, where one patient had advanced scleroderma with tight forearm skin and the other with a history of Reynaud's disease precluding the use of RFFF. In addition, both patients were morbidly obese with thick adipose tissue in the thigh making ALT flap not a suitable option. Instead, a PAP flap was chosen. After the harvest, the subcutaneous tissue thickness was measured to be 2.2 and 1.8 cm, respectively. The thinning was performed by removing the deep fat lobules of the superficial fat layer down to a final thickness of 0.4 and 0.3 cm, respectively. A 2 × 2 cm area surrounding the perforators were kept untouched. Both patients had uneventful postoperative course with one patient having a small donor area dehiscence that healed with local wound care. The functional outcomes at 1 year were good. “Thinned” PAP flap is a unique and novel application that may be an alternative in intraoral reconstruction when primary choices are not available. © 2014 Wiley Periodicals, Inc. Microsurgery 35:399–402, 2015. 相似文献
10.
Masato Kaku Hiroshi Shimasue Junji Ohtani Shunichi Kojima Hiromi Sumi Hanaka Shikata Shotoku Kojima Masahide Motokawa Tahsin Raquib Abonti Toshitsugu Kawata Kazuo Tanne Kotaro Tanimoto 《The Angle orthodontist》2015,85(3):518
This case report describes the treatment of a skeletal Class III malocclusion with autotransplantation of a cryopreserved tooth. To gain an esthetic facial profile and good occlusion, extraction of bimaxillary premolars and surgical therapy were chosen. The patient had chronic apical periodontitis on the lower left first molar. Although she did not feel any pain in that region, the tooth was considered to have a poor prognosis. Therefore, we cryopreserved the extracted premolars to prepare for autotransplantation in the lower first molar area because the tooth would probably need to be removed in the future. The teeth were frozen by a programmed freezer with a magnetic field (CAS freezer) that was developed for tissue cryopreservation and were cryopreserved in −150°C deep freezer. After 1.5 years of presurgical orthodontic treatment, bilateral sagittal split ramus osteotomy was performed for mandible setback. Improvement of the facial profile and the occlusion were achieved in the retention phase. Six years after the initial visit, the patient had pain on the lower left first molar, and discharge of pus was observed, so we extracted the lower left first molar and autotransplanted the cryopreserved premolar. Three years later, healthy periodontium was observed at the autotransplanted tooth. This case report suggests that long-term cryopreservation of teeth by a CAS freezer is useful for later autotransplantation, and this can be a viable technique to replace missing teeth. 相似文献