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1.
P Suwan J Grossman 《Asia-Pacific journal of public health / Asia-Pacific Academic Consortium for Public Health》1987,1(2):78-81
In response to a perceived lack of graduate-level training in Public Health (the ultimate goal being improved primary health care, PHC) in the Asia-Pacific region, the US agency for International Development and the University of Hawaii entered a cooperative agreement to assist institution of the Asia-Pacific Consortium for Public Health improve their PHC training and other aspects of institutional development. Research performed for the initial phase of the project in Thailand is presented. In collecting data on human resources, the concentration was on public health colleges and regional training centers for PHC in 4 regions, midwifery schools (6), nursing colleges (10), community medicine and nursing and (in 1 case) public health in 3 universities. Out of 121 instructors, 33 had masters degrees or the equivalent. The rest had Bachelors degrees in specialties such as Education, Nursing, Sanitation. 48 had ever attended PHC training programs run by the Training Center for PHC development at Mahidol University. 87 instructors reported needing more training. Only 9.9% of instructors thought that teaching methods (consisting mostly of lectures, and less frequently of discussion, guest speakers, reports, and projects) were adequate. 89.3% said that textbooks used for PHC teaching were inadequate. Some further problems and obstacles to PHC development included a lack of emphasis on field training of instructors, unclear lines of authority, and a high rate of trained village health communicator migration to jobs abroad, indicating a poor reward system. Recommendations include improved training on management topics needed for PHC, problem-centered as opposed to subject-oriented training and standardization of university curricula. 相似文献
2.
目的探讨新式阴道前、后壁联合修补术治疗盆腔脏器脱垂(POP)的临床效果。方法选择2017年1月至2021年1月,于南京医科大学附属淮安第一医院接受手术治疗的120例POP患者为研究对象。根据采用的手术方式,将其分为研究组(n=60,采用新式阴道前、后壁联合修补术)及对照组(n=60,采用腹腔镜下全子宫双侧附件切除术+传统阴道前、后壁修补术)。采用独立样本t检验及χ^(2)检验,对2组患者一般临床资料,术中及术后情况进行统计学比较。本研究经南京医科大学附属淮安第一医院医学伦理委员会批准(审批文号:YX-P-2020-023-01)。所有患者知情同意并与之签署临床研究知情同意书。结果①2组POP患者年龄、人体质量指数(BMI)、产次、绝经者比例及POP脱垂程度比较,差异均无统计学意义(P>0.05)。②研究组POP患者手术时间、术中出血量、总住院时间、术后住院时间及住院费用分别为(88.0±30.6)min、(24.7±36.0)mL、(7.3±2.1)d、(4.6±1.4)d及(10727±1812)元,均短于或低于对照组的(118.0±33.4)min、(56.7±43.8)mL、(9.8±2.3)d、(6.4±1.6)d及(26318±3890)元,并且差异均有统计学意义(t=5.130、4.372、6.218、6.558、28.138,均为P<0.001)。2组POP患者术后3、6、12个月复发率构成比比较,差异无统计学意义(P>0.05)。结论新式阴道前、后壁联合修补术在不增加POP患者术后复发率的基础上,不仅能缩短手术时间、减少患者术中出血量,还可以缩短住院时间、减少住院费用,并且易于操作,适宜推广。 相似文献
3.
Yan Li Yu Pan Shirong Cao Kensuke Sasaki Yinqiu Wang Aolei Niu Xiaofeng Fan Suwan Wang Ming-Zhi Zhang Raymond C. Harris 《Diabetes》2021,70(2):562
Renal epidermal growth factor receptor (EGFR) signaling is activated in models of diabetic nephropathy (DN), and inhibition of the EGFR signaling pathway protects against the development of DN. We have now determined that in cultured podocytes, high glucose led to increases in activation of EGFR signaling but decreases in autophagy activity as indicated by decreased beclin-1 and inhibition of LC3B autophagosome formation as well as increased rubicon (an autophagy inhibitor) and SQSTM1 (autophagy substrate). Either genetic (small interfering [si]EGFR) or pharmacologic (AG1478) inhibition of EGFR signaling attenuated the decreased autophagy activity. In addition, rubicon siRNA knockdown prevented high glucose–induced inhibition of autophagy in podocytes. We further examined whether selective EGFR deletion in podocytes affected the progression of DN in type 2 diabetes. Selective podocyte EGFR deletion had no effect on body weight or fasting blood sugars in either db/db mice or nos3−/−; db/db mice, a model of accelerated type 2 DN. However selective podocyte EGFR deletion led to relative podocyte preservation and marked reduction in albuminuria and glomerulosclerosis, renal proinflammatory cytokine/chemokine expression, and decreased profibrotic and fibrotic components in nos3−/−; db/db mice. Podocyte EGFR deletion led to decreased podocyte expression of rubicon, in association with increased podocyte autophagy activity. Therefore, activation of EGFR signaling in podocytes contributes to progression of DN at least in part by increasing rubicon expression, leading to subsequent autophagy inhibition and podocyte injury. 相似文献
4.
目的:制备新型聚多巴胺复合纳米颗粒,探究其对乳腺癌细胞的联合治疗.方法:以血清白蛋白,2,2-偶氮双[2-(2-咪唑啉-2-基)丙烷]二盐酸盐(AIPH),多巴胺为前驱物,通过一步氧化聚合法制备新型聚多巴胺纳米颗粒(AIPH@PB NPs);利用马尔文粒度分析仪、X射线光电子能谱和傅里叶红外光谱表征其理化学特性;利用紫... 相似文献
5.
关节镜手术联合内服中药膝痛康方治疗膝骨关节炎临床研究 总被引:2,自引:2,他引:0
目的 探讨关节镜手术联合内服中药膝痛康方治疗膝骨关节炎的疗效。方法 将马鞍山市人民医院2015年1月至2016年4月收治的41例膝骨关节炎病人采用随机数字表法分为两组,选择不同治疗方式。其中治疗组20例,应用关节镜手术联合内服中药膝痛康方治疗;对照组21例,应用单纯关节镜手术治疗。选用Lequsne 疗效评定、Lysholm膝关节评分评定其临床疗效。结果 所有病人均进行6个月以上随访。治疗后,两组膝关节功能及临床症状较前均有明显的好转。在Lequsne疗效评定上,总有效率治疗组85.00%明显优于对照组71.42%(χ2=4.113,P=0.042);在Lysholm膝关节评分上,治疗前两组评分差异无统计学意义(t=0.031,P=0.897);治疗后3个月、6个月与对照组相比,治疗组明显优于对照组(t=9.134,P=0.000;t=9.245,P=0.000)。结论 关节镜手术联合内服中药膝痛康方治疗膝骨关节炎取得了较好的疗效,具有较高的临床应用价值。 相似文献
6.
Lingling Yang Tianzhou Wu Jiang Li Jiaojiao Xin Dongyan Shi Jing Jiang Xi Liang Yingyan Lu Heng Yao Huafen Zhang Suwan Sun Tan Li Hozeifa Mohamed Hassan Mohamed Jiaqi Li Keke Ren Beibei Guo Xingping Zhou Jiaxian Chen Shaorui Hao Jiajia Chen Shaojie Xin Chen Pan Tao Han Yongping Chen Shumei Lin Zhongping Duan Xiaowei Xu Jianrong Huang Xin Chen Lanjuan Li Jun Li 《Hepatology research》2020,50(6):656-670
7.
二种方法治疗手外伤术后早期有炎性反应伤口的比较 总被引:1,自引:1,他引:0
目的 评价传统局部换药与点式直线偏振光近红外线疼痛治疗仪Super-Lizer HA-550(商品名"超激光疼痛治疗仪",S-L)照射加传统局部换药治疗手外伤术后早期有炎性反应伤口的疗效.方法 观察组先用生理盐水清洁后使用点式直线偏振光近红外线照射后再用传统换药法治疗.对照组使用传统局部换药疗法.结果 观察组:伤口治愈22例;伤口显效13例;伤口无变化1例;伤口加重0例,总有效率97.2%(35/36);对照组:伤口治愈6例;伤口显效17例;伤口无变化12例;伤口加重1例,总有效率63.9%(23/36).2组经χ2检验,有显著性差异(P<0.05).结论 使用点式直线偏振光近红外线照射后再用传统换药法治疗对手外伤术后早期有炎性反应伤口疗效优于单用传统局部换药法. 相似文献
8.
Wattanasirichaigoon D Visudtibhan A Phudhichareonrat S Chiemchanya S Leelahagul P Suwan K Supapannachart S 《The Southeast Asian journal of tropical medicine and public health》2003,34(1):202-207
Seizures are a common problem in neonates. Differential diagnoses include infection, trauma, hypoxia and congenital metabolic disorders. Among these, congenital metabolic disorder is less familiar to general pediatricians. We report two patients with nonketotic hyperglycinemia (NKH), a rare and lethal congenital metabolic disease. Transient hyperammonemia and transient hypouricemia, uncommon features found in NKH, were detected in one patient. High doses of sodium benzoate and dextromethorphan failed to modify the clinical course. Neuropathology denoted characteristic diffuse vacuolization and changes in reactive and gliotic astrocytes. The clinical course, biochemical findings, diagnostic approaches and diagnostic tests are discussed in detail. Recent modalities of treatment are reviewed. Because of its rarity and rapidly progressive course, it maybe underdiagnosed resulting in death before being recognized. Awareness of the possibility of congenital metabolic disorder in early neonatal catastrophe will increase the diagnostic rate. 相似文献
9.
Tansuphasiri U Muadcheingka T Choonharuangdej S 《The Southeast Asian journal of tropical medicine and public health》2005,36(3):663-672
A new diagnostic reagent was developed that is capable of detecting the presence of Clostridium perfringens rapidly and accurately compared to the conventional methods. C. perfringens enterotoxin (cpe) gene is the gene of interest since it encodes the enterotoxin responsible for food poisoning. Two new cpe-specific labeled DNA probes were evaluated using Southern and dot blot hybridization. Bacterial DNA was amplified by a duplex PCR procedure. The results showed that 40 enterotoxin producing C. perfringens strains generated two bands of amplicons with sizes of 420 and 280 bp, whereas 40 non-enterotoxin producing strains produced a single band of 280 bp on agarose gel-electrophoresis. No bands were observed from 32 strains of Clostridium spp and other bacteria. Southern blot analysis using either cpe-specific DNA or oligonucleotide probe showed hybridization specifically to the 420 bp band in enterotoxin-positive C. perfringens. On the dot blot membrane, both cpe-specific DNA and oligonucleotide probes were able to hybridize specifically with the corresponding DNA templates but with different efficacy (100% vs 91.1%). 相似文献
10.
Thaweboon S Thaweboon B Choonharuangdej S Chunhabundit P Suppakpatana P 《The Southeast Asian journal of tropical medicine and public health》2005,36(4):1066-1069
Retinoic acid has been known to play a key role in the regulation of bone cell differentiation and function. The effects of retinoic acid on human dental pulp cells, which contain several characteristics similar to those of bone cells, has yet to be elucidated extensively. The effects of retinoic acid on human dental pulp cells in terms of type I collagen and osteocalcin induction were investigated in vitro. Dental pulp cells obtained from the teeth of young patients (age between 18-22 years) were cultured and subsequently treated with various concentrations of retinoic acid (0, 10(-7), 10(-6), 10(-5) M) in serum-free DMEM. At different time intervals (8, 12 and 24 hours), the levels of type I collagen and osteocalcin secreted were determined using Type I Procollagen C-Peptide and Gla-type Osteocalcin EIA kits, respectively. Induction effects were evaluated using analysis of variance and the Duncan's multiple rank test. Retinoic acid at concentrations of 10(-5), 10(-6), 10(-7) M was able to induce type I collagen and osteocalcin production in human dental pulp cells within 12 hours of exposure. Dose-dependent induction was observed only after 24 hours. A two-fold increase in osteocalcin level was detected after exposed to 10(-5) M retinoic acid within 24 hours. Our data suggest that retinoic acid at concentrations of 10(-5), 10(-6), 10(-7) M has the ability to induce type I collagen and osteocalcin secretions in human dental pulp cells in vitro. 相似文献