全文获取类型
收费全文 | 1239篇 |
免费 | 93篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 24篇 |
儿科学 | 42篇 |
妇产科学 | 31篇 |
基础医学 | 132篇 |
口腔科学 | 64篇 |
临床医学 | 145篇 |
内科学 | 248篇 |
皮肤病学 | 15篇 |
神经病学 | 52篇 |
特种医学 | 36篇 |
外科学 | 199篇 |
综合类 | 39篇 |
一般理论 | 1篇 |
预防医学 | 99篇 |
眼科学 | 24篇 |
药学 | 87篇 |
中国医学 | 18篇 |
肿瘤学 | 84篇 |
出版年
2024年 | 4篇 |
2023年 | 15篇 |
2022年 | 42篇 |
2021年 | 69篇 |
2020年 | 48篇 |
2019年 | 69篇 |
2018年 | 83篇 |
2017年 | 49篇 |
2016年 | 41篇 |
2015年 | 41篇 |
2014年 | 59篇 |
2013年 | 83篇 |
2012年 | 96篇 |
2011年 | 105篇 |
2010年 | 55篇 |
2009年 | 47篇 |
2008年 | 70篇 |
2007年 | 50篇 |
2006年 | 50篇 |
2005年 | 41篇 |
2004年 | 38篇 |
2003年 | 36篇 |
2002年 | 36篇 |
2001年 | 11篇 |
2000年 | 9篇 |
1999年 | 9篇 |
1998年 | 11篇 |
1997年 | 2篇 |
1996年 | 5篇 |
1995年 | 5篇 |
1994年 | 6篇 |
1993年 | 6篇 |
1992年 | 5篇 |
1991年 | 8篇 |
1990年 | 3篇 |
1988年 | 3篇 |
1987年 | 2篇 |
1981年 | 2篇 |
1979年 | 2篇 |
1978年 | 5篇 |
1977年 | 1篇 |
1976年 | 3篇 |
1975年 | 2篇 |
1974年 | 2篇 |
1973年 | 1篇 |
1971年 | 1篇 |
1970年 | 2篇 |
1969年 | 1篇 |
1964年 | 1篇 |
1963年 | 1篇 |
排序方式: 共有1340条查询结果,搜索用时 15 毫秒
1.
Defining con-founders that affect the reliability of diagnostic tests for coronavirus disease 2019 is vital to breaking the chain of infection. The elderly population is a higher risk group for the emerging virus. However, gender seems to exert a critical role in modifying the infection risk among women owing to hormonal changes. The menopause transition is an exceptional period for older women where the protective and immunomodulatory effects of the estrogen hormone are lost. Accordingly, attention should be given to postmenopausal women since they will have an increased risk compared to their pre-menopausal peers. 相似文献
2.
3.
4.
5.
Muhammad Akram Randhawa 《Nippon Ishinkin Gakkai Zasshi》2006,47(4):313-318
Dimethyl sulfoxide(DMSO) is frequently used as a solvent for antifungal drugs in various studies to determine their MICs. Reports on comparative evaluation of methods for the susceptibility testing of antifungal drugs have shown there is poor agreement among methods. Besides other factors which could cause variability in the results, one important factor might be the effect of DMSO on the growth of fungi. The effect of DMSO on the growth of some species of Candida has been reported in the literature. The present study aimed at determination of the effect of different concentrations of DMSO (0.125 to 10%) on the growth of dermatophytes by agar diffusion method. There was no growth of fungi in 10% DMSO, between 1.25 and 5% there was a rather linear dose-related inhibitory effect on the growth, significantly different from the controls, and below 1% there was a variable effect among the species. DMSO down to 0.25% significantly inhibited the growth of most strains of M. canis. The lower concentrations of DMSO, which apparently do not affect the growth of fungi, may potentiate the effect of antifungal drugs. 相似文献
6.
This investigation tested the hypothesis that a noise-induced temporary threshold shift (TTS) can be attenuated by a peroxynitrite scavenger, ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one). Guinea pigs received an oral dose of the vehicle or 10 mg/kg ebselen 1 h before exposure to 115 dB SPL 4-kHz octave band noise for 3 h. In controls, auditory brainstem response (ABR) thresholds increased by 25–45 dB immediately after noise and returned to pre-exposure baseline thresholds 7 days later. Ebselen eliminated this ABR threshold shift following noise exposure. In controls, swelling of the afferent dendrites beneath the inner hair cells was evident immediately after noise, whereas ebselen significantly reduced this pathology. These findings suggest that scavenging peroxynitrite can attenuate noise-induced excitotoxicity and, thereby, TTS. 相似文献
7.
Tatyana B. Nesterova Sarah M. Duthie Nina A. Mazurok Al'bina A. Isaenko Nadezhda V. Rubtsova Suren M. Zakian Neil Brockdorff 《Chromosome research》1998,6(1):41-48
Comparative mapping of X-linked genes has progressed rapidly since Ohno's prediction that genes on the X chromosome should be conserved as a syntenic group in all mammals. Although several conserved blocks of homology between human and mouse have been discovered, rearrangements within the X chromosome have also been characterized. More recently, some exceptions to Ohno's law have been reported. We have used fluorescence in situ hybridization (FISH) to map five genes, Gla, G6pd, Hprt, Pgk1 and Xist, to two of the largest conserved segments of X material in five members of the genus Microtus (grey vole) and show that vole X chromosomes demonstrate greater homology to human than to mouse. Cytogenetic analysis indicates a relatively high frequency of rearrangement during vole evolution, although certain blocks of homology appear to be highly conserved in all species studied to date. On this basis we were able to predict the probable location of the rat X inactivation centre (Xic) based solely on high-resolution G-banding. Our prediction was then confirmed by mapping the rat Xist gene by FISH. The possible significance of conserving long-range chromosome structure in the vicinity of the Xic is discussed with respect to the mechanism of X inactivation. 相似文献
8.
Intrathecal immune response and virus-specific immunoglobulin M antibodies in laboratory diagnosis of acute poliomyelitis. 总被引:1,自引:2,他引:1
下载免费PDF全文
![点击此处可从《Journal of clinical microbiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
M Roivainen M Agboatwalla M Stenvik T Rys D S Akram T Hovi 《Journal of clinical microbiology》1993,31(9):2427-2432
The intrathecal immune response in 114 patients with clinically diagnosed acute poliomyelitis was studied by measuring poliovirus-specific immunoglobulin M (IgM) antibodies in cerebrospinal fluid (CSF) by a mu-capture immunoassay and by assessing the ratio between levels of poliovirus-neutralizing antibodies in serum and CSF. Fecal specimens were used for attempts to isolate the causative agents. Eighty-five percent of CSF specimens collected during the first 15 days of disease contained virus-specific IgM antibodies. Forty-five of 48 tested children (94%) also showed virus-specific IgM responses in their sera. Later on, the antibody levels decreased, and positive results after 30 days of onset of paralytic symptoms were rare. If the presence of poliovirus-specific IgM antibodies in the CSF was considered diagnostic, more cases were confirmed by this test than by virus isolation. A relative increase in poliovirus-neutralizing antibodies in the CSF was observed in about one-third of the cases; in all but three cases the increase was observed together with the presence of virus-specific IgM antibodies. A systemic virus-specific response can be seen and poliovirus can be isolated from a subclinically infected individual suffering from a concomitant poliomyelitis-like disease, while positive results by the two methods demonstrating an intrathecal immune response are likely to indicate a true causal relationship between infection and disease. Demonstration of poliovirus-specific IgM antibodies in the CSF thus appears to be a sensitive and specific method for laboratory confirmation of clinically diagnosed poliomyelitis. 相似文献
9.
Baboudjian Michael Tadrist Abel Gondran-Tellier Bastien McManus Robin Akiki Akram Gaillet Sarah Delaporte Veronique Carballeira Ana Andre Marc Karsenty Gilles Lechevallier Eric Boissier Romain 《International urology and nephrology》2021,53(4):685-690
International Urology and Nephrology - To report the efficacy and safety of povidone-iodine sclerotherapy of primary symptomatic lymphocele after kidney transplantation in a large contemporary... 相似文献
10.
Naeemi Sahar Eidi Akram Khanbabaee Ramezan Sadri-Ardekani Homan Kajbafzadeh Abdol-Mohammad 《International urology and nephrology》2021,53(8):1543-1550
International Urology and Nephrology - Successful in vitro transplantation of spermatogonial stem cells (SSCs) demands effective culture systems for SSCs proliferation and differentiation. Natural... 相似文献