全文获取类型
收费全文 | 1296篇 |
免费 | 91篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 36篇 |
妇产科学 | 4篇 |
基础医学 | 190篇 |
口腔科学 | 43篇 |
临床医学 | 98篇 |
内科学 | 293篇 |
皮肤病学 | 42篇 |
神经病学 | 202篇 |
特种医学 | 112篇 |
外科学 | 121篇 |
综合类 | 21篇 |
预防医学 | 32篇 |
眼科学 | 29篇 |
药学 | 74篇 |
中国医学 | 5篇 |
肿瘤学 | 89篇 |
出版年
2022年 | 10篇 |
2021年 | 20篇 |
2020年 | 18篇 |
2019年 | 14篇 |
2018年 | 26篇 |
2017年 | 17篇 |
2016年 | 21篇 |
2015年 | 25篇 |
2014年 | 25篇 |
2013年 | 37篇 |
2012年 | 60篇 |
2011年 | 47篇 |
2010年 | 58篇 |
2009年 | 38篇 |
2008年 | 39篇 |
2007年 | 45篇 |
2006年 | 45篇 |
2005年 | 55篇 |
2004年 | 61篇 |
2003年 | 56篇 |
2002年 | 46篇 |
2001年 | 39篇 |
2000年 | 42篇 |
1999年 | 43篇 |
1998年 | 22篇 |
1997年 | 20篇 |
1996年 | 21篇 |
1995年 | 17篇 |
1994年 | 19篇 |
1993年 | 15篇 |
1992年 | 29篇 |
1991年 | 33篇 |
1990年 | 47篇 |
1989年 | 33篇 |
1988年 | 24篇 |
1987年 | 15篇 |
1986年 | 31篇 |
1985年 | 19篇 |
1984年 | 15篇 |
1983年 | 10篇 |
1981年 | 10篇 |
1980年 | 8篇 |
1977年 | 11篇 |
1976年 | 11篇 |
1975年 | 9篇 |
1971年 | 9篇 |
1970年 | 7篇 |
1969年 | 9篇 |
1968年 | 8篇 |
1967年 | 7篇 |
排序方式: 共有1396条查询结果,搜索用时 15 毫秒
1.
2.
The purpose of this study was to examine the effects of object self-stimulation on the task-interrupting self-stimulatory behavior and prevocational work responses of a 13-year-old autistic boy. Using a multiple-baseline design across three diferent prevocational tasks, a systematic manipulation of object self-stimulation was associated with increases in correct rates and decreases in task-interrupting self-stimulatory behaviors. An analysis of these data indicates that self-stimulatory behavior may be shaped to facilitate performance proficiencies. Social validation information suggests that favorable generalized responding had occurred. On the basis of findings from this study, future research needs are discussed. 相似文献
3.
Metabolic fate of 125I-labeled batroxobin in rats and dogs 总被引:1,自引:0,他引:1
125I-Labeled batroxobin was prepared and following its intravenous and subcutaneous administrations to rats and dogs, the blood radioactivity was determined. In the both species following the intravenous injections, the decrease in radioactivity was biexponential. Following subcutaneous administration, radioactivity became maximal at 6h and decreased in a manner similar to that of the beta-phase of the intravenous injection. The blood concentration of fibrinogen in dogs was also determined. After the intravenous injection, fibrinogen became undetectable 1h later, and appeared again in the blood at 24h. After the subcutaneous injection, the decrease was not so rapid. Fibrinogen resumed its original levels at 7 day after the administration in both the routes. Radioactivity after the both injections was excreted generally in the urine in about the same amounts. The total urinary and fecal excretions in rats and dogs were 80 and 95%, respectively. The distribution of radioactivity in the tissues was examined by counting technique and whole-body autoradiography. Radioactivity predominantly accumulated in the thyroid and stomach and could also be found in the kidneys and liver in fair amounts. The distribution patterns of radioactivity for both the routes of administrations and also for male and pregnant rats were basically the same. In fetus rats, a slight distribution was noted. From the results of gel filtration chromatography and trichloroacetic acid fractionation, [125I] batroxobin was metabolized soon after the administration to afford low molecular substances such as 125I-ion in the plasma and urine. 相似文献
4.
O. Yamasaki A. Tristan T. Yamaguchi M. Sugai G. Lina M. Bes F. Vandenesch J. Etienne 《Clinical microbiology and infection》2006,12(6):585-588
Exfoliative toxin D (ETD) was identified recently as a new exfoliative toxin serotype. Like other exfoliative toxins, ETD induces intra-epidermal cleavage through the granular layer of the epidermis of neonatal mice. The distribution of ETD production was investigated in Staphylococcus aureus isolates from infected and colonised patients in France. The etd gene was found in 55 (10.5%) of 522 isolates tested. Isolates responsible for bullous impetigo and generalised staphylococcal scalded skin syndrome did not harbour etd, but etd was significantly more frequent in isolates causing cutaneous abscesses and furuncles. Most etd- and Panton-Valentine leukocidin-positive strains belonged to the clone of community-acquired methicillin-resistant S. aureus spreading currently throughout France. 相似文献
5.
6.
S Sugai 《Current opinion in rheumatology》1992,4(5):666-671
Over the past year, many reports have been published on a variety of clinical manifestations related to antiphospholipid antibodies. The low prevalence of anticardiolipin antibodies with the rare occurrence of thrombosis and a low rate of fetal loss in studies in Malaysia and China showed a potential role for local factors. A study of cross-reactive idiotype of the anticardiolipin antibody suggested that anticardiolipin antibodies are derived from a set of natural autoreactive clones. Regarding the pathogenic role of the antiphospholipid antibody, evidence has been presented that the epitopes formed between cardiolipin and beta 2 glycoprotein I are the targets of the antiphospholipid antibody. Complement activation, abnormalities of natural anticoagulants such as protein S deficiency, and genetic association with DR4, DR7, and DRw53 have also been studied. 相似文献
7.
R Dixon AM Hughes K Nairn M Sellers JV Kemp RA Yates 《Cephalalgia : an international journal of headache》1998,18(7):468-475
Zolmitriptan (ZomigTM ) is a 5HT1B/1D agonist which has the ability to cross the intact blood-brain barrier to access central as well as peripheral receptors. Because of the potential for central nervous system side effects, this randomized, double-blind, placebo-controlled, 6-period crossover study evaluated the effects of 2.5 and 5 mg doses of zolmitriptan on psychomotor performance and investigated any pharmacodynamic or pharmacokinetic interaction with diazepam. Twelve healthy volunteers received the following "treatments" as single doses: zolmitriptan 2.5 mg, zolmitriptan 5 mg, diazepam 10 mg, zolmitriptan 2.5 mg+diazepam 10 mg, zolmitriptan 5 mg+diazepam 10 mg and placebo. Pre-dose and at 1, 4, 8, and 24 h post-dose, the following validated battery of psychomotor tests was performed: Bond-Lader visual analogue scales (calmness, contentedness, and alertness factors), critical flicker fusion test, choice reaction time (recognition, motor, and total reaction times), finger-tapping test, number cancellation test and digit symbol substitution test. Plasma concentrations of zolmitriptan, its active metabolite, and diazepam and its active metabolites were measured at the same timepoints. Zolmitriptan 2.5 and 5 mg had no effect on psychomotor function when given alone. In contrast, diazepam 10 mg had profound effects, consistent with its sedative properties, but there was no synergism on concomitant administration of either dose of zolmitriptan. Plasma concentrations of zolmitriptan, diazepam, and their respective active metabolites were similar when the two drugs were given alone or in combination. 相似文献
8.
9.
Summary— Experiments were designed to determine whether or not indapamide, an antihypertensive agent with vasodilator properties, inhibits endothelium-dependent contractions. Rings of aortae with and without endothelium from spontaneously hypertensive rats (SHR) were suspended in conventional organ chambers for the measurement of isometric force. Acetylcholine and adenosine diphosphate-β-S in the presence of a nitric oxide synthase inhibitor, caused endothelium-dependent contractions, which were inhibited by indapamide. The compound (10−4 M) also slightly reduced the contractions of rings without endothelium evoked by U-46,619, which activates thromboxane-endoperoxide receptors. These results demonstrate that indapamide inhibits endothelium-dependent contractions in the SHR aorta, and suggest that the inhibition is due, at least in part, to the action of the drug on the hypertensive vascular smooth muscle. 相似文献
10.
Kaoru Nagahori Jun Itakura Hiroyasu Miura Hidemitsu Sugai Masayuki Yamamoto Yoshiro Matsumoto Takao Ainota Yoshihiro Akahane 《Journal of Hepato-Biliary-Pancreatic Surgery》1995,2(3):288-291
We report a metastatic pulmonary tumor resected by video-assisted thoracoscopic surgery. A 63-year-old female was found to
have four nodules of hepatocellular carcinoma (HCC) in January 1991; after non-surgical treatment, the tumors had become necrotic.
In June 1992, a new HCC nodule was found. After infusion chemotherapy, it became necrotic. In September 1993, a solitary lung
tumor, 2.4 cm in diameter, appeared at the periphery of the right lung. Because the tumor was considered to be a metastatic
HCC rather than a primary lung cancer, it was removed by thoracoscopic wedge resection. Although whether metastasectomy contributes
to prolongation of survival is still controversial, thoracoscopic pulmonary resection may be indicated for solitary peripheral
metastasis, if the primary HCC is well controlled by multidisciplinary treatment. 相似文献