Autoimmune Effect of Antibodies against the SARS-CoV-2 Nucleoprotein

COVID-19 caused by SARS-CoV-2 is continuing to spread around the world and drastically affect our daily life. New strains appear, and the severity of the course of the disease itself seems to be decreasing, but even people who have been ill on an outpatient basis suffer post-COVID consequences. Partly, it is associated with the autoimmune reactions, so debates about the development of new vaccines and the need for vaccination/revaccination continue. In this study we performed an analysis of the antibody response of patients with COVID-19 to linear and conformational epitopes of viral proteins using ELISA, chip array and western blot with analysis of correlations between antibody titer, disease severity, and complications. We have shown that the presence of IgG antibodies to the nucleoprotein can deteriorate the course of the disease, induce multiple direct COVID-19 symptoms, and contribute to long-term post-covid symptoms. We analyzed the cross reactivity of antibodies to SARS-CoV-2 with own human proteins and showed that antibodies to the nucleocapsid protein can bind to human proteins. In accordance with the possibility of HLA presentation, the main possible targets of the autoantibodies were identified. People with HLA alleles A01:01; A26:01; B39:01; B15:01 are most susceptible to the development of autoimmune processes after COVID-19.     

Occlusion patterns of dental arches containing implant-supported restoration

An experimental and clinical study was carried out on 76 patients with implant-supported restorations in the posterior zones of the lower jaw, divided in two groups (with no signs of bone resorption around the implants and with resorption signs) and one control group. The results of the study allowed optimizing the angulation of dental implants, providing an opportunity for individual positioning of dental implant in the mandible depending on the direction of functional load.     

The change of the degree of arterial hypertension after ischemic cerebral stroke according to 24-hour arterial pressure monitoring results

The paper presents a retrospective analysis of the medical records of 147 patients with arterial hypertension (AH) and old ischemic cerebral stroke (ICS), who had undergone annual hospital treatment and 24-hour arterial pressure monitoring (24HAPM) for five years before ICS developed. The patients were observed and underwent 24HAPM during five years after ICS as well. The changes in average 24-hour systolic arterial pressure (SAP av.) within the 10 years were analyzed in 98 of the 147 patients who had remained in the group by the end of the observation period. The changes in SAP av. after ICS were variable. Most patients displayed slight SAP av. growth by the end of the investigation; at the same time, in 6 of the 98 patients SAP av. became lower by 7 mbar or more after ICS. The authors suppose that this decrease in the arterial pressure occurred due to the disappearance of cerebral ischemic focus in the area of ICS. The authors propose the term "ischemic cerebrovascular AH" and an algorithm of the examination of AH patients with non-stable arterial pressure due to brachiocephalic arterial pathology.     

Prognostication and prevention of acute postoperative pancreatitis]

Equations for accurate prediction of the course of postoperative pancreatitis are developed by multifactorial regression analysis for purposeful prevention of this condition. An injury to the pancreas and the "readiness" of hepatoduodenal organs to a degenerative destructive process are significant for the development of pancreatitis. A differentiated strategy is developed for preventing this complication during the post- and intraoperative period by protease inhibitors, cytostatics, and other nonspecific methods.     

Effect of industrial noise on the prevalence of arterial hypertension

Women exposed to industrial noise were subjected to a one-stage overall examination. The levels and character of industrial noise, microclimate, labour tension and the scope of physical activity had been evaluated before. Altogether 1584 women aged 17-55 years were examined to form 4 groups to be compared. The prevalence of arterial hypertension (AH) was found to be slightly higher in women exposed to the noise 90-100 dBA. It was shown by the method of the purposeful pair matching that the probability of an increase in the incidence of AH under exposure to industrial noise in the absence of other risk factors is 1.1--=1.9%; when combined with one of the factors such as overweight, aggravated heredity or aggravated obstetrical-gynecological anamnesis it rises up to 15%.