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排序方式: 共有123条查询结果,搜索用时 15 毫秒
1.
Successful use of sirolimus for refractory atrial ectopic tachycardia in a child with cardiac rhabdomyoma
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Sanja Ninic MD Marija Kalaba MD Bosiljka Jovicic MD Vladislav Vukomanovic MD PhD Sergej Prijic MD PhD Biljana Vucetic MD Ruzica Kravljanac MD PhD Ana Vujic MD PhD Jovan Kosutic MD PhD 《Annals of noninvasive electrocardiology》2017,22(4)
Cardiac rhabdomyomas are common in tuberous sclerosis. We report a child who developed rhabdomyoma related arrhythmia refractory to antiarrhythmic drug therapy. Reversion of the atrial ectopic tachycardia was achieved with mammalian target of rapamycin pathway (mTOR) inhibitor sirolimus. As per our knowledge, this is the first time that sirolimus has been successfully used in this setting. 相似文献
2.
Zorana Andric Dusan Popadic Barbara Jovanovic Ivana Jaglicic Svetlana Bojic Ruzica Simonovic 《Human immunology》2014
This study provides the first published detailed analysis of five loci polymorphisms as well as reports of two, three and five loci haplotype frequencies in the Serbian population in a sample of 1992 volunteer bone marrow donors recruited from different part of the country. Typing was performed by PCR SSO method combined with PCR SSP techniques to resolve ambiguities. In total, 16 HLA-A, 28 HLA-B, 14 HLA-C, 13 HLA-DRB1 and 5 HLA-DQB1 allelic groups were identified. The most frequent in allele groups are HLA-A∗02 (29.5%), HLA-A∗01 (14.2%), HLA-B∗35 (13.1%), HLA-B∗51 (12.8%), HLA-C∗07 (24.8%), HLA-DRB1∗11 (16.9%), HLA-DRB1∗13 (13.2%), HLA-DQB1∗03 (33.3%) and DQB1∗05 (33.0%). The most frequent three- and five-loci haplotypes were A∗01-B∗08-DRB1∗03 (5.9%) and A∗02-B∗18-DRB1∗11 (1.9%), A∗01-B∗08-C∗07-DRB1∗03-DQB1∗02 (6.6%) followed by A∗02-B∗18-C∗07-DRB1∗11-DQB1∗03 (2.5%), then A∗33-B∗14-C∗08-DRB1∗01-DQB1∗05 and A∗02-B∗35-C∗04-DRB1∗16-DQB1∗05 (2.2% both), respectively. The results of cluster analysis showed that the Serbian population is closely related to the populations living in central Balkan and neighboring European regions. The level of allelic diversity found in this study are relevant to facilitate searching for unrelated matched donor and provide a healthy control population from our region that should be useful in the future disease association study. 相似文献
3.
Dejan Vukajlovic Goran Milasinovic Lazar Angelkov Velibor Ristic Milosav Tomovic Ruzica Jurcevic Petar Otasevic 《Archives of Medical Science》2014,10(4):684-691
Introduction
In this study, we sought to determine whether myocardial contractile reserve (CR) assessed by dobutamine stress echocardiography (DSE) can identify patients who experience nearly complete normalization of left ventricular (LV) function after the implantation of a cardiac resynchronization therapy (CRT) pacemaker.Material and methods
The study group consisted of 55 consecutive patients with non-ischemic dilated cardiomyopathy, LV ejection fraction (LVEF) < 35%, and prolonged QRS complex duration, who were scheduled for CRT pacemaker implantation. The DSE (20 µg/kg/min) was performed in all patients. The CR assessment was based on a change in the wall motion score index (ΔWMSI) and ΔLVEF during DSE. Super-response was defined as an increase in LVEF to > 50% and reduction in left ventricular end-systolic dimension to < 40 mm 12 months following the CRT implantation.Results
A total of 7 patients (12.7%) were identified as super-responders to CRT. When compared to non-super-responders, these patients had significantly higher values of the dobutamine-induced change in ΔWMSI (1.031 ±0.120 vs. 0.49 ±0.371, p < 0.01), and ΔEF (17.9 ±2.2 vs. 8.8 ±6.2, p < 0.01). Receiver operating characteristic analysis showed that dobutamine-induced changes in ΔWMSI ≥ 0.7 and ≥ 14% for ΔEF are the best discriminators for a super-response. Patients with ΔWMSI ≥ 0.7 and ΔEF ≥ 14% are significantly less often hospitalized (p < 0.01) for worsening of heart failure during 28.5 ±3.0 months of the follow-up.Conclusions
Contractile reserve assessed by DSE can identify patients with dilated cardiomyopathy who are likely to experience near normalization of LV function following CRT. 相似文献4.
Bubanj TB Perovic SV Milicevic RM Jovcic SB Marjanovic ZO Djordjevic MM 《The Journal of urology》2004,171(5):1876-1879
PURPOSE: We assessed sexual behavior and sexual function in adults operated on for hypospadias. MATERIALS AND METHODS: Long-term psychosexual adjustment was assessed with a standardized questionnaire which was mailed to 57 patients with hypospadias older than 18 years and 60 age matched normal control subjects. RESULTS: A total of 37 patients with hypospadias and 39 controls participated. Self-reported strength of libido on a scale of 1 to 5 was shown to be similar in the 2 groups. Patients with hypospadias did not have problems in achieving erection and average self-rated quality of erection ranging from 1 to 5 was the same as that of controls (mean value 4.5). Patients with hypospadias noted curvature in a downward direction in a significantly higher proportion compared to controls (40% vs 18%, respectively). There were 13 patients with hypospadias who had ejaculation difficulties, of whom 6 had spraying and 7 had only dribbling of ejaculate. Patients with hypospadias masturbated significantly less often, were significantly less sexually active and had a smaller total number of sexual partners compared to control subjects. Control subjects were significantly more completely satisfied with their sexual life compared to patients with hypospadias (76.92% vs 51.35%, respectively). CONCLUSIONS: Sexual function of patients who underwent surgery for hypospadias in general is not affected. However, there is clearly a difference in certain aspects of sexual behavior between patients with hypospadias and controls. Followup and adequate counselling of patients who underwent surgery for hypospadias in adult life is necessary. 相似文献
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Rationale. Modafinil is a first-line wake-promoting medication and a useful therapeutic alternative to psychostimulant medications for
excessive daytime sleepiness.
Objective. This 5-week, randomized, open-label study evaluated three strategies for switching patients from methylphenidate, a commonly
used psychostimulant, to modafinil.
Methods. Patients (n=40) with excessive daytime sleepiness related to narcolepsy, who had received previous treatment with methylphenidate, were
switched from methylphenidate to modafinil (200 mg/day followed by 400 mg/day) without a washout period between treatments,
with a 2-day washout period between treatments, or by using a taper-down/titrate-up protocol. Adverse events were recorded
throughout the study, and Epworth Sleepiness Scale scores were determined at the end of the study.
Results. The majority of patients (95%) were successfully switched to modafinil. At the study end point, mean Epworth Sleepiness Scale
scores were <12 for each treatment group. All three switching strategies were well tolerated, with adverse events mild or
moderate in nature. Adverse events most frequently reported during modafinil treatment were among those seen previously in
large-scale, placebo-controlled studies. There were no meaningful differences among the treatment groups in the frequency
or severity of adverse events or in their relationship to modafinil treatment. Only one patient discontinued modafinil treatment
because of a treatment-related adverse event (i.e. moderate headache); another patient discontinued due to insufficient efficacy.
Conclusions. Switching from methylphenidate to modafinil was well tolerated with or without a washout period or when the methylphenidate
dose is gradually tapered during initiation of modafinil therapy. Daytime wakefulness was maintained in patients who have
switched from methylphenidate to modafinil. These data suggest that patients with narcolepsy may be switched from methylphenidate
to modafinil with few complications and inconveniences.
Electronic Publication 相似文献
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Oral squamous cell carcinoma (OSCC) is characterized by high mortality rates. High incidence of local recurrences in the normal-appearing surgical margins of OSCC patients indicates the existence molecular alterations, including DNA methylation, which could not be detectable by histopathologic analysis. The objective of our study was to determine correlation of tumor-related genes hypermethylation detected in histopathologically negative surgical margins with clinical and prognostic parameters. The genes selected for methylation analysis covered a wide range cellular processes including cell cycle control (p16), apoptosis (DAPK and RASSF1A), Wnt signaling (APC, WIF1 and RUNX3), cell-cell adhesion (E-cad), and DNA repair (MGMT and hMLH1). All of 47 patients had histologically confirmed negative surgical margins. For each of patient, samples from primary malignant tissue and the two consecutive surgical margins were taken at the time of surgery. DNA methylation was determined by multiplex nested methylation-specific PCR. Twenty-seven patients were margin-positive for promoter hypermethylation of at least one gene under study. The presence of DAPK promoter hypermethylation detected in surgical margins was associated with the decreased overall survival (p=0.004, log rank test). Multivariate analysis revealed that DAPK promoter hypermethylation in surgical margins is an independent prognostic factor for overall survival, HR=4.105 (1.458-11.555, 95% CI, p=0.007). Hypermethylation of other tumor-related genes under study did not have prognostic significance. These results demonstrate that DNA hypermethylation in histologically negative surgical margins is a frequent event. Promoter hypermethylation of DAPK gene detected in surgical margins may be a useful molecular marker for the poor survival in OSCC patients. Further investigation into the therapeutic potential of these findings in OSCC is warranted. 相似文献