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de Lima IR Alves GG Soriano CA Campaneli AP Gasparoto TH Ramos ES de Sena LÁ Rossi AM Granjeiro JM 《Journal of biomedical materials research. Part A》2011,98(3):351-358
Hydroxyapatite (HA), a stable and biocompatible material for bone tissue therapy, may present a variable stoichiometry and accept a large number of cationic substitutions. Such substitutions may modify the chemical activity of HA surface, with possible impact on biocompatibility. In this work, we assessed the effects of calcium substitution with diverse divalent cations (Pb(2+), Sr(2+), Co(2+), Zn(2+), Fe(2+), Cu(2+), or Mg(2+)) on the biological behavior of HA. Physicochemical analyses revealed that apatite characteristics related to crystallinity and calcium dissolution/uptake rates are very sensitive to the nature of cationic substitution. Cytocompatibility was evaluated by mitochondrial activity, membrane integrity, cell density, proapoptotic potential, and adhesion tests. With the exception of Zn-HA, all the substituted HAs induced some level of apoptosis. The highest apoptosis levels were observed for Mg-HA and Co-HA. Cu-HA was the only material to impair simultaneously mitochondrial activity, membrane integrity, and cell density. The highest relative cell densities after exposure to the modified HAs were observed for Mg-HA and Zn-HA, while Co-HA significantly improved cell adhesion onto HA surface. These results show that changes on surface dissolution caused by cationic substitution, as well as the increase of metal species released to biological media, were the main responsible factors related to alterations on HA biocompatibility. 相似文献
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Falcão Gleicy Gabriela Vitória Spínola Carneiro Sarmento Viviane Almeida Dutra Brenda Soares Russoni Bruno de Oliveira Letycia Santos Costa Dayana Alves Brites Carlos Bouqout Jerry E. Lins-Kusterer Liliane 《Clinical oral investigations》2022,26(3):2565-2573
Clinical Oral Investigations - To compare the oral health status and oral health-related quality of life (OHRQoL) in symptomatic and asymptomatic patients with human T-cell leukemia virus-1... 相似文献
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