全文获取类型
收费全文 | 7708篇 |
免费 | 462篇 |
国内免费 | 44篇 |
专业分类
耳鼻咽喉 | 81篇 |
儿科学 | 240篇 |
妇产科学 | 159篇 |
基础医学 | 929篇 |
口腔科学 | 148篇 |
临床医学 | 603篇 |
内科学 | 2018篇 |
皮肤病学 | 179篇 |
神经病学 | 782篇 |
特种医学 | 287篇 |
外科学 | 1127篇 |
综合类 | 44篇 |
预防医学 | 347篇 |
眼科学 | 87篇 |
药学 | 397篇 |
1篇 | |
中国医学 | 9篇 |
肿瘤学 | 776篇 |
出版年
2023年 | 63篇 |
2022年 | 97篇 |
2021年 | 211篇 |
2020年 | 105篇 |
2019年 | 161篇 |
2018年 | 175篇 |
2017年 | 136篇 |
2016年 | 187篇 |
2015年 | 174篇 |
2014年 | 223篇 |
2013年 | 298篇 |
2012年 | 407篇 |
2011年 | 391篇 |
2010年 | 270篇 |
2009年 | 232篇 |
2008年 | 370篇 |
2007年 | 416篇 |
2006年 | 405篇 |
2005年 | 379篇 |
2004年 | 354篇 |
2003年 | 290篇 |
2002年 | 273篇 |
2001年 | 244篇 |
2000年 | 261篇 |
1999年 | 195篇 |
1998年 | 104篇 |
1997年 | 113篇 |
1996年 | 112篇 |
1995年 | 73篇 |
1994年 | 77篇 |
1993年 | 57篇 |
1992年 | 137篇 |
1991年 | 125篇 |
1990年 | 112篇 |
1989年 | 114篇 |
1988年 | 102篇 |
1987年 | 91篇 |
1986年 | 76篇 |
1985年 | 70篇 |
1984年 | 92篇 |
1983年 | 59篇 |
1982年 | 44篇 |
1981年 | 39篇 |
1980年 | 31篇 |
1979年 | 42篇 |
1978年 | 31篇 |
1976年 | 33篇 |
1974年 | 17篇 |
1973年 | 17篇 |
1972年 | 16篇 |
排序方式: 共有8214条查询结果,搜索用时 15 毫秒
1.
2.
3.
Maria Russo Claudio Lucifora Francesco Pucciarelli Bruno Piccoli 《La Medicina del lavoro》2019,110(2):115
Background:Workplace hazards are a significant source of health impairment for workers and of financial losses for firms. EU directives on workers’ health and safety standards significantly contributed to reduce reported occupational injuries, yet the incidence and prevalence of work-related mental illness is still very high.Objectives:We investigated the association between work-related hazards and individuals’ perceived mental health. We reviewed the existing evidence on the channels through which task-related factors, adverse agents and psychosocial factors are expected to affect workers’ health, with specific regard to mental health.Methods:We used data from the fifth wave of the European Working Conditions Survey, covering over 40,000 face-to-face interviews with workers in 34 countries, which includes information on socio-demographic characteristics, firms and jobs attributes, employment status, as well as working conditions and health status. We carried out an empirical analysis with multivariate regression models in order to estimate the relationship between workers’ mental health problems and workplace risk factors.Results:21,020 interviews were used in the multivariate analysis. We found strong correlations between hazards and various indicators of mental health. Among hazardous agents, low temperatures (β=0.0287) and contact with infectious materials (β=0.0394) were positively associated with mental health outcomes. Among task/sequence-related factors, tiring or painful positions (β=0.0713), repetitive hand/arm movements (β=0.0255), working with VDUs (β=0.0301), repetitive tasks <10 min (β=0.0859) and working in evenings (β=0.00754) were positively associated with mental health. Various psychosocial risk factors related to both the content of the job (for example, frequent disruptive interruptions: β=0.219, working in free time: β=0.0759, poor work-life balance: β=0.228) as well as the job context (for example, bad employment prospects: β=0.177, low decisional autonomy: β=0.245, bad social relations: β=0.186, workplace violence: β=0.411) were positively associated with mental health. The main results of the decomposition show that an important contribution to workers’ overall mental distress at work is associated with psychosocial risk factors (up to 60% for depression/anxiety symptoms and sleep disorders), while the contribution of somatic factors is on average lower (up to 20% for overall fatigue).Conclusions:We argue that action is needed to improve workers’ mental well-being, and reduce the economic costs for both the national health system and employers. Regulations and traditional economic measures are unlikely to prove successful in providing adequate standards of primary and secondary preventive measures in the work place without an appropriate and reliable Risk Assessment Procedure.Key words: Work hazards, risk assessment, job content, mental health 相似文献
4.
5.
6.
D Monnier† C Vidal‡ L Martin§ A Danzon¶ F Pelletier† E Puzenat† MP Algros†† D Blanc† R Laurent† PH Humbert† F Aubin† 《Journal of the European Academy of Dermatology and Venereology》2006,20(10):1237-1242
BACKGROUND: Dermatofibrosarcoma protuberans (DFSP) is a rare malignant tumour of the skin, with an estimated incidence of 0.8 to five cases per 1 million people per year. OBJECTIVE: To study epidemiological, immunohistochemical and clinical features, delay in diagnosis, type of treatment and outcome of DFSP from 1982 to 2002. METHODS: Using data from the population-based cancer registry, 66 patients with pathologically proved DFSP were included (fibrosarcomatous DFSP were excluded). Each patient lived in one of the four departments of Franche-Comté (overall population of 1 million people) at the time of diagnosis. The main data sources came from public and private pathology laboratories and medical records. The rules of the International Agency for Research on Cancer were applied. RESULTS: The estimated incidence of DFSP in Franche-Comté was about three new cases per 1 million people per year. Male patients were affected 1.2 times as often as female patients were. The trunk (45%) followed by the proximal extremities (38%) were the most frequent locations. DFSP occurred mainly in young adults between 20 and 39 years of age. Mean age at diagnosis was 43 years, and the mean delay in diagnosis was 10.08 years. Our 66 patients initially underwent a radical local excision. Among them, 27% experienced one or more local recurrences during 9.6 years of follow-up. There was one regional lymph node recurrence without visceral metastases. These recurrences were significantly related to the initial peripheral resection margins. We observed a local recurrence rate of 47% for margins less than 3 cm, vs. only 7% for margins ranging from 3 to 5 cm [P=0.004; OR=0.229 (95%, CI=0.103-0.510)]. The mean time to a first local recurrence was 2.65 years. Nevertheless, there was no death due to the DFSP course at the end of the follow-up, and the final outcome was favourable. CONCLUSION: Our study emphasizes the importance of wide local excision with margins of at least 3 cm in order to prevent local recurrence. However, the recent development of inhibitors of signal transduction by the PDGFB pathway should soon modify the surgical strategy, which is often too mutilating. 相似文献
7.
Michele D. Mignogna Stefano Fedele Lucio Lo Russo Lorenzo Lo Muzio 《Journal of oral pathology & medicine》2003,32(4):200-205
BACKGROUND: The recurrent chronic orofacial swelling caused by orofacial granulomatosis (OFG) can cause significant cosmetic and functional problems but can be prevented if the disease is diagnosed early and promptly treated. Although the enlargement of the lips is described to be the most common presenting complaint, the clinical onset of OFG may be characterized by minor associated mucosal and neurological manifestations, making early diagnosis very difficult or, sometimes, merely presumable. PATIENTS AND METHODS: We retrospectively analyzed the clinical manifestations of 19 patients with OFG, who were examined at our institution between 1998 and 2002, in order to determine their initial manifestations and presenting symptoms. RESULTS: A total of 10 patients showed classical recurrent enlargement of the lips (six lower; four upper) as presenting symptom. In the other nine patients, OFG onset was characterized by transient unilateral facial nerve palsy (two cases), intraoral manifestations (two cases), recurrent swelling of the periorbital area (two cases), of the chin (one case), of the zygomatic area (one case), and of the cheeks (one case). CONCLUSION: Our data underlined that OFG onset could be frequently characterized by widely variable, multiform, and temporary clinical findings. Involvement of atypical sites of the orofacial region and presence of single minor manifestations may occur as presenting symptoms, often preceding the development of traditional clinical findings. 相似文献
8.
Accuracy evaluation of image registration and segmentation tools used in conformal treatment planning of prostate cancer. 总被引:1,自引:0,他引:1
Stefania Pallotta Marta Bucciolini Serenella Russo Cinzia Talamonti Talamonti Cinzia Giampaolo Biti 《Computerized medical imaging and graphics》2006,30(1):1-7
Segmentation and registration tools are commonly used in radiotherapy for target and at risk organs localisation. In this work the performances of three different segmentation tools and of a surface matching registration technique, used on computed tomography (CT) and magnetic resonance (MR) images for the treatment planning of conformal prostate carcinoma, are studied. The accuracy of the segmentation and registration tools was evaluated by phantom experiment and on patient data, respectively. A preliminary estimate of MR image distortion was also performed. 相似文献
9.
Low signal intensity on long-repetition-time MR sequences has been observed in deep gray matter structures in patients with multiple sclerosis. This T2 shortening most likely represents a nonspecific degenerative process. We recently observed T2 shortening in the pericentral cortical gray matter and subcortical white matter in a patient with severe multiple sclerosis and we postulate that this represents an additional manifestation of neural degeneration. 相似文献
10.