全文获取类型
收费全文 | 351篇 |
免费 | 19篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 25篇 |
妇产科学 | 3篇 |
基础医学 | 24篇 |
口腔科学 | 7篇 |
临床医学 | 18篇 |
内科学 | 50篇 |
皮肤病学 | 79篇 |
神经病学 | 18篇 |
特种医学 | 9篇 |
外科学 | 33篇 |
综合类 | 54篇 |
预防医学 | 27篇 |
药学 | 8篇 |
肿瘤学 | 12篇 |
出版年
2023年 | 6篇 |
2022年 | 8篇 |
2021年 | 7篇 |
2020年 | 5篇 |
2019年 | 7篇 |
2018年 | 12篇 |
2017年 | 5篇 |
2016年 | 9篇 |
2015年 | 12篇 |
2014年 | 9篇 |
2013年 | 15篇 |
2012年 | 17篇 |
2011年 | 32篇 |
2010年 | 16篇 |
2009年 | 13篇 |
2008年 | 24篇 |
2007年 | 25篇 |
2006年 | 19篇 |
2005年 | 24篇 |
2004年 | 18篇 |
2003年 | 23篇 |
2002年 | 12篇 |
2001年 | 5篇 |
2000年 | 2篇 |
1999年 | 7篇 |
1997年 | 2篇 |
1996年 | 3篇 |
1994年 | 5篇 |
1993年 | 1篇 |
1992年 | 3篇 |
1991年 | 3篇 |
1990年 | 1篇 |
1989年 | 5篇 |
1988年 | 5篇 |
1987年 | 3篇 |
1980年 | 2篇 |
1978年 | 2篇 |
1974年 | 1篇 |
1967年 | 1篇 |
1933年 | 1篇 |
排序方式: 共有370条查询结果,搜索用时 109 毫秒
1.
Pharmacokinetic interaction of antimicrobial agents with levomethadon in drug-addicted AIDS patients
N. H. Brockmeyer L. Mertins M. Goos 《Journal of molecular medicine (Berlin, Germany)》1991,69(1):16-18
Summary Morphine and its derivatives are metabolized by the liver microsomal enzyme system with a high first-pass effect after oral application. In four of 44 HIV-infected i.v. drug abusers who participated in a levomethadon maintenance program, we observed sustained symptoms of under-dosage and loss of effect of there to fore well-tolerated substitution therapy during rifampin treatment or therapy with zidovudine or fucidic acid. As a pharmacological model substance for cytochrome p 450 enzymes, measurement of antipyrine in serum by high pressure liquid chromatography revealed induction of cytochrome p 450 isoenzymes. The half-life of antipyrine decreased (patient 1 from 11.3 to 8.4 h and patient 2 from 10.7 to 7.6 h after rifampin, patient 3 from 12.2 to 8.6 h after fucidic acid, and patient 4 from 10.6 to 8.6 h after zidovudine). In i.v. drug abusers on levomethadon maintenance programs, adjustment of the levomethadon dosage may be necessary when specific therapy for HIV infection and associated diseases requires the use of drugs known to be potent inducers of the liver microsomal enzyme system.Abbreviations IVDA
intravenous drug abusers
-
C
total body clearance
- PCP
pneumoncystis carinii pneumonia
- INH
isonazid
- EMB
ethambutol
- PZA
pyrazinamide
- t1/2
half-life 相似文献
2.
U. R. Hengge N. H. Brockmeyer M. Goos 《Journal of molecular medicine (Berlin, Germany)》1992,70(10):922-926
Summary Frequent complications of human immunodeficiency virus infection are hematopoietic failure and poor tolerance of myelosuppressive drugs. Reasons for neutropenia resulting from hematopoietic failure are infection of the bone marrow and hematotoxicity of treatment with zidovudine, ganciclovir, sulfonamides, and interferons. Moreover, tumor necrosis factor-, transforming growth factor- and interferon- have been shown to suppress proliferation of bone marrow cells. Both granulocyte (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) increase neutrophil counts and ameliorate phagocytic and bactericidic function of neutrophils. We report eight cases of AIDS patients with serious infections and neutropenia (< 750 cells/l), who were treated concomitantly with recombinant human G-CSF (3–4 g subcutaneously per kilogram body weight daily). G-CSF treatment was well tolerated in all patients and showed no side effects or disturbances of other lineages than neutrophils. Life-threatening bacterial infections were treated successfully by stimulating the neutrophil immune system. This therapy shortened the duration of subsequent treatment with antibiotics. Since human immunodeficiency virus infects CD4-positive monocytes and macrophages, which are stimulated by GM-CSF, G-CSF seems to be the cytokine of choice, if stimulation of the neutrophil lineage is warranted.Abbreviations G-CSF
granulocyte colony-stimulating factor
- GM-CSF
granulocyte-macrophage colony-stimulating factor
- HIV
human immunodeficiency virus 相似文献
3.
4.
5.
Wolfgang Fuchs Norbert H. Brockmeyer 《Journal der Deutschen Dermatologischen Gesellschaft》2014,12(6):451-464
In no other medical field former rare infections of the 1980th and 1990th occur again as this is seen in the field of venerology which is as well based on the mobility of the population. Increasing rates of infections in Europe, and increasing bacteriological resistances face health professionals with new challenges. The WHO estimates more than 340 million cases of illnesses worldwide every year. Diseases caused by sexually transmitted infections (STI) in a strict sense are syphilis, gonorrhea, lymphogranuloma venereum, granuloma inguinale, and chancroid. In a wider sense, all illnesses are included which can mainly be transmitted through sexual contact. The term “sexual contact” has to be seen widely, from close physical contact to all variants of sexual behavior. This CME article is an overview of the most common occurring sexually transmitted infections in clinical practice. Both, basic knowledge as well as recent developments are discussed below. 相似文献
6.
Preliminary Evidence for a Nexus between Rumination,Behavioural Avoidance,Motive Satisfaction and Depression
下载免费PDF全文
![点击此处可从《Clinical psychology & psychotherapy》网站下载免费的PDF全文](/ch/ext_images/free.gif)
7.
8.
9.
Titus Josef Brinker Fabian Buslaff Caelán Haney Benedikt Gaim Ailís Ceara Haney Selina Marisa Schmidt Marc Phillipp Silchmüller Lava Taha Lena Jakob Hannah Maria Baumert Marvin Hallmann Marlene Heckl Jonas Alfitian Christian Martin Brieske Evgenia Petrova Divizieva Jilada Wilhelm Gabriel Hillebrand Dominik Penka Sanjeevan Raveendranathan Netzwerk Aufklärung gegen Tabak Janina Leonie Suhre 《Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz》2018,61(11):1453-1461
Smoking is the leading preventable cause of premature death in Germany. The network “Education Against Tobacco” (EAT) is an initiative that was founded in Germany in 2012, in which more than 3500 medical students and physicians engage in volunteer work in about 80 medical faculties in 14 countries. In this article, the concept, activities, objectives and associated research studies oft he EAT initiative are introduced.On the school level, the initiative addresses 10- to 15-year-old secondary school students. In addition to a multimodal approach, school visits use modern media such as facemorphing apps, which are not only used by students (45,000 per year in 14 countries), but by a total of over 500,000 other people as well. The effectiveness of the school-based intervention is currently being investigated in randomised long-term studies with 20,000 adolescents in Germany. A first long-term study demonstrated evidence of a protective effect regarding the onset of smoking, especially among female students, students having a low level of education and students with a migratory background.The programme educates several hundred prospective physicians at 13 (of 28 participating) German medical faculties each year in science-based elective courses for the well-established smoking cessation counselling of patients and sensitises them to the tobacco epidemic. The approved members engage in dialogue with local members of the German house of representatives as “Ärzteverband Tabakprävention”.EAT motivates the prospective generation of physicians, initially through prevention in school settings, to face the challenge of national tobacco control at the university and federal level. 相似文献
10.
Jennifer Klump Ulrike Phillipp Marie Follo Anna Eremin Hannes Lehmann Sigrun Nestel Nikolas von Bubnoff Irina Nazarenko 《Nanomedicine : nanotechnology, biology, and medicine》2018,14(3):875-882
Clinical evidence in oncology argues for the advantages of performing molecular analysis of blood biomarkers to provide information about systemic changes and tumor heterogeneity.Whereas the diagnostic value of cell-free circulating DNA (fcDNA) has successfully been demonstrated in several studies, DNA enclosed in extracellular vesicles (EV) has only recently been described, and its potential diagnostic value is unclear. We established a protocol for separation of EV and fc fractions and tested for presence of mutant BRAFV600E mediating resistance to Vemurafenib and cKITD816V mediating resistance to Imatinib in blood of patients with melanoma and mastocytosis. Our results show that EV contain significantly higher amounts of total DNA as compared to the fc fraction. However, about ten-fold higher copy numbers of the wild type and mutant BRAF and cKIT were detected in the fcDNA fraction supporting its diagnostic value and pointing to differences in fc and EV DNA content. 相似文献